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癌により誘発される血管透過性亢進像
http://hdl.handle.net/10191/40943
http://hdl.handle.net/10191/40943f74fba2c-adbb-4614-9cf8-fd94bf9b3423
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
102(9)_546-558.pdf (4.3 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-04-06 | |||||
| タイトル | ||||||
| タイトル | 癌により誘発される血管透過性亢進像 | |||||
| タイトル | ||||||
| タイトル | 癌により誘発される血管透過性亢進像 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | tumor-induced vascular hyper-permeability | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vascular permeability-increasing factor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | complement activation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 癌誘発性血管透過性亢進 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血管透過性亢進因子 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 補体活性化 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Characterization of Tumor-Induced Vascular Hyper-Permeabihty | |||||
| 著者 |
佐藤, 徳光
× 佐藤, 徳光× 新村, 末雄× 藤巻, 雅邦× 藤沢, 信義× 前田, 宜俊 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 140707 | |||||
| 姓名 | Sato, Norimitsu L. | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 140708 | |||||
| 姓名 | Niimura, Sueo | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 140709 | |||||
| 姓名 | Fujimaki, Masakuni | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 140710 | |||||
| 姓名 | Fujisawa, Nobuyoshi | |||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 140711 | |||||
| 姓名 | Maeda, Yoshitaka | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The vascular bed in a murine dermal tissue responded to inoculated tumor cells by two-phased changes in the vascular permeability. The initial increase in the vascular permeability was seen in an early stage (1 to 3 day post tumor cells inoculation), and the inflammation was sensitive to glutathione. Glucocorticoids reduced the increased vascular permeability, but neither acetylsalicylic acid nor indomethacin did. The later vascular response was produced by a growing solid tumor in a continuous mode beginning at 5th to 10th day post inoculation. The degree of the increased vascular permeability in this chronic phase was in direct proportion to the wet weight of the solid tumor, and the inflammation was insensitive to glutathione. Glucocorticoids reduced the increased vascular permeability, but neither acetylsalicylic acid nor indomethacin did. Increased vascular permeability was inducible by the subcutaneous injection of a solid tumor extract rich in γ-globulins precipitable at 20-33% saturation of ammonium sulfate. The vascular permeability-increasing activity of the tumor extract was reducible in the presence of highly polymerized dextran sulfate (DS-500) which showed a strong anticomplementary activity, but not by other substances such as dextran sulfate with a low molecular weight, nonsulfated dextran, chondroitin sulfate or heparin. As the tumor extract includes γ-globulins in aggregated or bound form and adsorbs complements, it is assumed that the aggregated γ-globulins increase vascular permeability by triggering the complement activation system in the skin. DS-500 might antagonize the process. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 102, 号 9, p. 546-558, 発行日 1988-09 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
