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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第103巻第6号

実験的糖尿病ラットにおける消化管運動の生理学的研究

http://hdl.handle.net/10191/41297
http://hdl.handle.net/10191/41297
02477450-8a66-4bda-9108-e1c3bdecb6a8
名前 / ファイル ライセンス アクション
103(6)_520-532.pdf 103(6)_520-532.pdf (2.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-04-11
タイトル
タイトル 実験的糖尿病ラットにおける消化管運動の生理学的研究
タイトル
言語 en
タイトル 実験的糖尿病ラットにおける消化管運動の生理学的研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 streptozotocin diabetic rats
キーワード
主題Scheme Other
主題 gastrointestinal tract
キーワード
主題Scheme Other
主題 motor activity
キーワード
主題Scheme Other
主題 compliance
キーワード
主題Scheme Other
主題 transmitters
キーワード
主題Scheme Other
主題 ストレプトゾトシン糖尿病
キーワード
主題Scheme Other
主題 消化管運動
キーワード
主題Scheme Other
主題 コンプライアンス
キーワード
主題Scheme Other
主題 伝達物質
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Physiological Studies on Motor Activity of Gastrointestinal Tract in Experimental Diabetic rats
著者 唐木田, 丈夫

× 唐木田, 丈夫

WEKO 138354

唐木田, 丈夫

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著者別名
識別子 138355
識別子Scheme WEKO
姓名 Karakida, Takeo
抄録
内容記述タイプ Abstract
内容記述 In order to elucidate the physiological mechanisms of diabetic gastrointestinal disorders, isolated gastrointestinal segments of streptozotocin diabetic rats were studied in vitro from the following viewpoint, i. e. , the size, motor activities, passive physical properties, drug-induced contractility and transmitter contents. 1) Diabetic rats had longer small and large intestine than normal. Wet weight of the diabetic duodenum, jejunum, ileum, colon and caecumu was heavier than that of normal. Stomach weight was similar between diabetic and normal rats. 2) Motor activities were examined by recording the changes in frequency and amplitude of spontaneous intraluminal pressure of isolated preparations, as well as those in electromyographs with suction electrodes. Frequency of the diabetic upper intestine, especially of the duodenum, was significantly lower than that of normal. Amplitude of intraluminal pressure in the diabetic jejunum and caecum was smaller than that of normal. These results suggested the pacemaker disorders in diabetic preparations. 3) Acetylcholine and substance P induced-contractility of the diabetc duodenum, jejunum and ileum was smaller than that of normal, both in longitudinal and circular muscle preparations. However, colonic responsibility to acetylcholine and substance P was similar between diabetic and normal preparations. 4) Substance P and somatostatin contents in gastrointestinal tract were determined by radioimmunoassay. Substance P and somatostatin content per wet weight was increased in the diabetic corpus of stomach. Substance P was decreased in the ileum and caecum and somatostatin was decreased in the caecum. 5) Passive mechanical properties were compared by recording pressure-volume relationships of the isolated gastrointestinal tracts by infusing Tyrode's solution into them. Maximal volume infused was larger in diabetic than in normal preparations even after corrected for length and wet weight. Therefore, compliance or distensibility was higher in diabetic than in normal preparations. In conclusion, disorders of diabetic gastrointestinal tract were suggested to be due to pacemaker disorders, higher compliance, decreased drug-responsibility and transmitter content.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 103, 号 6, p. 520-532, 発行日 1989-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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