{"_buckets": {"deposit": "992ebc88-d571-471f-8a02-9bf5203db922"}, "_deposit": {"id": "22877", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22877"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022877", "sets": ["456", "1209"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Studies on the Antireproductive Mechanism of RU38486, an Antiprogesterone Agent, to Pregnant Rats"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "479", "bibliographicPageStart": "472", "bibliographicVolumeNumber": "103", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Effects of antiprogesterone (RU38486) were studied in pregnant rats. This synthetic compound (5, 10mg/kg) induced complete abortion when it was administered (p. o.) on day 8, 9, 10, 11, 12, 13 postconception. The anti-implantation effects were decreased when administered on day 6, 7 especially in cases of 5mg/kg. As to the anti-implantation effects, complete block was seen in all cases when 10mg/kg was given to the rats. Serial macroscopical and histological studies were carried out and its antiprogestational activity was demonstrated on the decidual capillary and cells prior to the changes of progesterone level. Changes of trophoblast were not remarkable, and no immunological effects were shown in decidual area. These data suggest that anti-implantational and abortificient action of RU38486 mainly consists in the uterine endometrial (decidual) level.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "138345", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Nishimura, Mitsuru"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "西村, 満"}], "nameIdentifiers": [{"nameIdentifier": "138344", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(6)_472-479.pdf", "filesize": [{"value": "3.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3700000.0, "url": {"label": "103(6)_472-479.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22877/files/103(6)_472-479.pdf"}, "version_id": "cf5d0989-4e0b-4de3-a375-b6143620d6e7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "RU38486", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-implantation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "abortion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "decidua", "subitem_subject_scheme": "Other"}, {"subitem_subject": "着床阻害", "subitem_subject_scheme": "Other"}, {"subitem_subject": "流産", "subitem_subject_scheme": "Other"}, {"subitem_subject": "脱落膜", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究"}, {"subitem_title": "抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1209"], "permalink_uri": "http://hdl.handle.net/10191/41291", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-04-11"}, "publish_date": "2016-04-11", "publish_status": "0", "recid": "22877", "relation": {}, "relation_version_is_last": true, "title": ["抗プロゲステロン剤, RU38486の妊娠ラットに対する流産誘発機序に関する研究"], "weko_shared_id": null}