{"_buckets": {"deposit": "7a9cedb1-10ce-4094-a102-64cdce1189ea"}, "_deposit": {"id": "22764", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22764"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022764", "sets": ["456", "1205"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "LDL Receptor and Familial Hypercholesterolemia(Receptor Diseases)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "808", "bibliographicPageStart": "801", "bibliographicVolumeNumber": "103", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Familial hypercholesterolemia (FH) is one of the most common inherited disorders both in Caucasian countries and Japan. It had been already established that the genetic defects of low density lipoprotein receptors (LDL-R) resulted in FH. Homozygous FH were classified into three phenotypes (receptor negative, receptor defective and internalization defective type) according to their binding activity to LDL and internalization ability of the complex. Their allelic mutations were also divided into four classes (Class 1: failure of synthesis of LDL-R, Class 2: failure of LDL-R transport from endoplasmic reticulum to Golgi apparatus, Class 3: failure of binding of LDL-R to LDL, Class 4: failure of clustering of coated pits). Moreover, recent studies focused attention on the structure of LDL-R gene and their function. We reviewed these investigations and related them with the clinical manifestrations of FH, especially in heterozygotes, from our data and clinical experiences.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "137921", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miida, Takashi"}]}, {"nameIdentifiers": [{"nameIdentifier": "137922", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shibata, Akira"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "三井田, 孝"}], "nameIdentifiers": [{"nameIdentifier": "137919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柴田, 昭"}], "nameIdentifiers": [{"nameIdentifier": "137920", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(10)_801-808.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "103(10)_801-808.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22764/files/103(10)_801-808.pdf"}, "version_id": "7e1a0680-c3d6-4267-b394-77c9fb157d73"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "LDL receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "familial hypercholesterolemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "coronary artery disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LDLリセプター", "subitem_subject_scheme": "Other"}, {"subitem_subject": "家族性高コレステロール血症", "subitem_subject_scheme": "Other"}, {"subitem_subject": "冠動脈疾患", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "3) LDLレセプターと家族性高コレステロール血症(シンポジウム レセプターとその臨床, 第443回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "3) LDLレセプターと家族性高コレステロール血症(シンポジウム レセプターとその臨床, 第443回新潟医学会)"}, {"subitem_title": "3) LDLレセプターと家族性高コレステロール血症(シンポジウム レセプターとその臨床, 第443回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1205"], "permalink_uri": "http://hdl.handle.net/10191/41425", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-04-12"}, "publish_date": "2016-04-12", "publish_status": "0", "recid": "22764", "relation": {}, "relation_version_is_last": true, "title": ["3) LDLレセプターと家族性高コレステロール血症(シンポジウム レセプターとその臨床, 第443回新潟医学会)"], "weko_shared_id": null}