{"_buckets": {"deposit": "7a9cedb1-10ce-4094-a102-64cdce1189ea"}, "_deposit": {"id": "22764", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "22764"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00022764"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "LDL Receptor and Familial Hypercholesterolemia(Receptor Diseases)"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1989-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "808", "bibliographicPageStart": "801", "bibliographicVolumeNumber": "103", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Familial hypercholesterolemia (FH) is one of the most common inherited disorders both in Caucasian countries and Japan. It had been already established that the genetic defects of low density lipoprotein receptors (LDL-R) resulted in FH. Homozygous FH were classified into three phenotypes (receptor negative, receptor defective and internalization defective type) according to their binding activity to LDL and internalization ability of the complex. Their allelic mutations were also divided into four classes (Class 1: failure of synthesis of LDL-R, Class 2: failure of LDL-R transport from endoplasmic reticulum to Golgi apparatus, Class 3: failure of binding of LDL-R to LDL, Class 4: failure of clustering of coated pits). Moreover, recent studies focused attention on the structure of LDL-R gene and their function. We reviewed these investigations and related them with the clinical manifestrations of FH, especially in heterozygotes, from our data and clinical experiences.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "137921", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Miida, Takashi"}]}, {"nameIdentifiers": [{"nameIdentifier": "137922", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Shibata, Akira"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e09\u4e95\u7530, \u5b5d"}], "nameIdentifiers": [{"nameIdentifier": "137919", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u67f4\u7530, \u662d"}], "nameIdentifiers": [{"nameIdentifier": "137920", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(10)_801-808.pdf", "filesize": [{"value": "1.5 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1500000.0, "url": {"label": "103(10)_801-808.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22764/files/103(10)_801-808.pdf"}, "version_id": "7e1a0680-c3d6-4267-b394-77c9fb157d73"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "LDL receptor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "familial hypercholesterolemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "coronary artery disease", "subitem_subject_scheme": "Other"}, {"subitem_subject": "LDL\u30ea\u30bb\u30d7\u30bf\u30fc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u51a0\u52d5\u8108\u75be\u60a3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "3) LDL\u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "3) LDL\u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "3) LDL\u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1205"], "permalink_uri": "http://hdl.handle.net/10191/41425", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-04-12"}, "publish_date": "2016-04-12", "publish_status": "0", "recid": "22764", "relation": {}, "relation_version_is_last": true, "title": ["3) LDL\u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u5bb6\u65cf\u6027\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}