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Recent studies on the mechanisms of transmembrane signalling pathways indicate that many hormone and neurotransmitter receptors are coupled to a limited number of intracellular signal-transduction systems, in which a family of GTP-binding proteins, originally termed G or N proteins, serves as transducers to couple receptor-generated signals to many effector systems including phosphatidyl inositol turnover and ion channels as well as adenylate cyclase. Along with these new findings in receptology, new insights into the pathogenesis of receptor diseases emerged. In this brief communication, I attempted to review recent progress in this field in relation to the pathogenesis of the receptor diseases.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "137916", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Yoshida, Yutaka"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5409\u7530, \u8c4a"}], "nameIdentifiers": [{"nameIdentifier": "137915", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "103(10)_793-797.pdf", "filesize": [{"value": "967.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 967400.0, "url": {"label": "103(10)_793-797.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/22762/files/103(10)_793-797.pdf"}, "version_id": "52af6341-c73f-4bab-984d-dd1095abeb6a"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "receptors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "molecular structure of receptors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "receptor internalizaton", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GTP-binding proteins", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intracellular signal transduction systems", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ec\u30bb\u30d7\u30bf\u30fc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u5206\u5b50\u69cb\u9020", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u7d30\u80de\u5185\u9665\u5165", "subitem_subject_scheme": "Other"}, {"subitem_subject": "GTP\u7d50\u5408\u86cb\u767d\u8cea", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u7d30\u80de\u5185\u60c5\u5831\u4f1d\u9054\u7cfb", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "1) \u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u6a5f\u80fd\u3068\u69cb\u9020(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "1) \u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u6a5f\u80fd\u3068\u69cb\u9020(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"}, {"subitem_title": "1) \u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u6a5f\u80fd\u3068\u69cb\u9020(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1205"], "permalink_uri": "http://hdl.handle.net/10191/41429", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-04-12"}, "publish_date": "2016-04-12", "publish_status": "0", "recid": "22762", "relation": {}, "relation_version_is_last": true, "title": ["1) \u30ec\u30bb\u30d7\u30bf\u30fc\u306e\u6a5f\u80fd\u3068\u69cb\u9020(\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u305d\u306e\u81e8\u5e8a, \u7b2c443\u56de\u65b0\u6f5f\u533b\u5b66\u4f1a)"], "weko_shared_id": null}