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Administration of the drug was begun from the age of 13 weeks, when polyclonal B cell activation and lupus nephropathy were apparent. Treatment with DSP up to 20 weeks of age at a dose of 2mg/kg twice a day, 5mg/kg daily or 20mg/kg three times a week strongly suppressed the increment of IgG-producing cell numbers in the spleen, and decreased serum levels of immune complexes and anti-DNA antibodies. Glomerular histological score by light microscopy and IgG and C3 deposition estimated by immunofluorescence were remarkably improved. In MRL/1pr mice, DSP reduced the swelling of lymph node and the numbers of Thy-1^+, B220^+ cell population in lymphoid organs. Responsiveness to Con A and IL-2 production of spleen cells were improved by the treatment. Thus, DSP was shown to suppress the progression of polyclonal B cell activation and lupus nephropathy in MRL/1pr and male BXSB mice. These results suggest that DSP might be used as a therapeutic agent for human erythematosus.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "137505", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ito, Satoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "137506", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Fujiwara, Michio"}]}, {"nameIdentifiers": [{"nameIdentifier": "137507", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Arakawa, Masaaki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", 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