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少量のgold sodium thiomalateを投与した慢性関節リウマチ罹患関節滑膜組織の検討 : 金粒子の局在および投与前後の滑膜内血管内皮細胞の変化
http://hdl.handle.net/10191/33635
http://hdl.handle.net/10191/336356c9bca39-ec99-4e95-afec-fb41406b9eae
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
104(1)_51-67.pdf (9.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-21 | |||||
| タイトル | ||||||
| タイトル | 少量のgold sodium thiomalateを投与した慢性関節リウマチ罹患関節滑膜組織の検討 : 金粒子の局在および投与前後の滑膜内血管内皮細胞の変化 | |||||
| タイトル | ||||||
| タイトル | 少量のgold sodium thiomalateを投与した慢性関節リウマチ罹患関節滑膜組織の検討 : 金粒子の局在および投与前後の滑膜内血管内皮細胞の変化 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Rheumatoid arthritis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | gold sodium thiomalate | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | synovial membrane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | vascular endothelial cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 慢性関節リウマチ | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 金製剤 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 滑膜 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 血管内皮細胞 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | A Histological Investigation of the Rheumatoid Synovial Membrane Treated with Small Dosis of Gold Sodium Thiomalate : With Special Reference to the Localization of Gold and Morphological Change in Vascular Endothelial Cells of Synovial Membrane | |||||
| 著者 |
若槻, 秀夫
× 若槻, 秀夫 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 137413 | |||||
| 姓名 | Wakatsuki, Hideo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Localization of gold particles and the shapes formed by their conglomeration were investigated in RA-afflicted articular synovia of 31 cases after administration of small dosis of gold sodium thiomalate (GST) (in 23 cases less than 10 mg and in 8 cases less than 25 mg at a time were administered) with electron probe microanalyzer and electron microscope. In 9 cases in which less than 10 mg of GST at a time was administered and synovial biopsies before and after administration of GST were performed, relation between clinical finding with Lansbury index as its parameter, synovial histology, localization and the shapes of gold particles was investigated. Furthermore, the observation that proliferation of cultured endothelial cells of umbilical veins was inhibited by administration of small dosis of GST having taken into consideration, vascular density of superficial synovial layer and morphological change of EC were measured, which led to the following conclusion. 1. Gold particles were mostly found in lysosomes of macrophages located in deeper layer of articular synovia in contract to cases with administration of greater dosis of GST where they were said to be found mostly in lining cells of synovia. However, no marked difference in the shape of precipitated gold particles was observed. 2. Lansbury index coincided with histological change in 8 of 9 cases, but not with localization and shape of gold particles. 3. Vascular density in the superficial layer of articular synovia after administration of GST increased in cases with progressing histological change, but did not decrease in cases with improving histology. 4. Decrease in the height of EC, shrinkage and flattening of nuclei were seen in all cases after administration of GST. 5. Findings above described seemed to suggest that GST inhibited synovitis by causing flattening of EC, rather than inhibition of new vascular formation. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 1, p. 51-67, 発行日 1990-01 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
