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新潟におけるサイトメガロウイルス感染症に関する疫学的研究
http://hdl.handle.net/10191/33674
http://hdl.handle.net/10191/3367452652b82-15d8-4522-bac1-8e5881131673
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
104(2)_110-121.pdf (2.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-10-22 | |||||
| タイトル | ||||||
| タイトル | 新潟におけるサイトメガロウイルス感染症に関する疫学的研究 | |||||
| タイトル | ||||||
| タイトル | 新潟におけるサイトメガロウイルス感染症に関する疫学的研究 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Cytomegalovirus | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reactivation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | サイトメガロウイルス | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 再活性化 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 先天性感染症 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | An Epidemiological Study on Cytomegalovirus Infection in Niigata | |||||
| 著者 |
久保田, 康夫
× 久保田, 康夫 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 137176 | |||||
| 姓名 | Kubota, Yasuo | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A rural area (Suibara County) of Niigata Prefecture was investigated for the prevalence of cytomegalovirus (CMV) infection among the residents, particulary among the pregnant women and newborn infants, using serological and virological methods. Complement-fixation test revealed the incidence of CMV antibody in 93.9% of the cord-blood speciments. By employing a human diploid cell line, CMV were isolated from urines of infants, covering the age groups of below 2-month-old to 14-year-old with a highest isolation rate of 63.3% at 9- to 11-month-old, indicating the occurrence of perinatal infection in the same rate at least. These findings in the perinatal conditions also anticipated an ubiquitous prevalence of CMV infection among the other groups of residents and alarmed a signal for the risk of clinical hazards due to reactivation of the latent virus, provided that the individuals were subjected to a compromised state of immunity, receiving organ-transplantation for example. For the reactivation mechanisms of the latent virus in pregnancy, impairment of cellular immunity has been raised as a possibility. Pregnant women were compared with nonpregnant women for the efficiency of the peripheral lymphocytes in the blast-transformation, where the specimens of the former group gave a significantly (p<0.01) reduced rate of the reaction with CMV antigen. On the reactivation of the latent virus in pregnancy, virus infection seems to be circumscribed to that of the local tissues, probably because of the pre-existing antibody in the circulation, which may be boosted by the viral antigen, that produced additionally. In fact, CMV antibody titers in the third trimester significantly (p<0.01) exceeded that in the preceding trimesters. This circulating antibody may prevent or modify the intra-uterine infection of fetuses with the reactivated CMV. Interferon titers of pregnant women were also assayed in the circulation to elevated as the gestation progressed, but the clinical implication of this finding remained for further exploration. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 2, p. 110-121, 発行日 1990-02 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
