WEKO3
アイテム
家兎における急性非呼吸性アシドーシス時の横隔神経活動
http://hdl.handle.net/10191/34075
http://hdl.handle.net/10191/34075cd8d3168-cdc5-42e3-aef8-1eb525cb6387
名前 / ファイル | ライセンス | アクション |
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104(5)_394-408.pdf (2.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2015-11-09 | |||||
タイトル | ||||||
タイトル | 家兎における急性非呼吸性アシドーシス時の横隔神経活動 | |||||
タイトル | ||||||
タイトル | 家兎における急性非呼吸性アシドーシス時の横隔神経活動 | |||||
言語 | en | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rabbit | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | non-respiratory acute acidosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | arterial hydrogen ion concentration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phrenic nerve activity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | F_ECO_2 clamp | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | central and peripheral chemoreceptors | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ウサギ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 非呼吸性急性アシドーシス | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 動脈血水素イオン濃度 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 横隔神経活動 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 終末呼気CO_2濃度固定 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 中枢ならびに末梢化学受容器 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Studies on Phrenic Nerve Activity during Acute Non-Respiratory Acidosis in the Rabbit | |||||
著者 |
安達, 智恵子
× 安達, 智恵子 |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 135379 | |||||
姓名 | Adachi, Chieko | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In urethane anesthetized rabbits, arterial hydrogen ion concentration ([H^+]a) was altered by slow intravenous injection of 0.3 N HCl under the clamp of CO_2 concentration in end-expiratory air (F_ECO_2). Central respiratory activity of these preparations was monitored through phrenic nerve discharge. Under vagotomy and peripheral chemodenervation, [H^+]a increase above normal induced the fall of respiratory frequency. This fall was manifested by the prolongation in expiratory duration (T_E) but not by the prolongation in inspiratory duration (T_I). Contrary, the phrenic discharge height (A; correspond to tidal volume, V_T) increased gradually. These results seem to suggest that in acute non-respiratory acidosis the central chemoreceptors play respiratory compensation not through the control of respiratory frequency but through the control of V_T. Therefore, regulations of respiratory frequency and V_T may take place at different regions in the central nervous system. It may be speculated that respiratory frequency-related chemoreceptor is located deep in the brain which is affected by arterial blood, while V_T related-chemoreceptor is located on the surface of the brain which is affected by cerebro-spinal fluid (CSF) because response time lag was recognized in respiratory frequency and V_T. With vagotomy and intact peripheral chemoreceptors, respiratory frequencies remained at control value with constant T_I and T_E during the increase in [H^+]a. However, after starting acid injection, magnitude of phrenic discharge activity increased rapidly and reached the peak in about 20 min. Therfore, peripheral chemoreceptors, recovered respiratory frequency to the control level and incresed the V_T simultaneously. It is concluded that in acute non-respiratory acidosis the peripheral chemoreceptors play more urgent, important and essential role for respiratory compensation than the central chemoreceptors do. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 5, p. 394-408, 発行日 1990-05 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |