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各種白血病細胞株の分化誘導におけるアラキドン酸代謝産物の動態
http://hdl.handle.net/10191/34205
http://hdl.handle.net/10191/342055fe4df89-d3ee-483e-899f-8c9a37747112
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
104(6)_487-496.pdf (2.2 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2015-11-11 | |||||
| タイトル | ||||||
| タイトル | 各種白血病細胞株の分化誘導におけるアラキドン酸代謝産物の動態 | |||||
| タイトル | ||||||
| タイトル | 各種白血病細胞株の分化誘導におけるアラキドン酸代謝産物の動態 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | prostagrandin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | leukemic cell lines | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PMA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 1-α | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 25-dihydroxy vitamin D_3 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | プロスタグランディン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 白血病細胞株 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 活性化ビタミンD_3 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Qualitative and Quantitative Measurement of Arachidonic Acid Metabolites Produced by Different Types of Leukemic Cell Lines During Granulocyte and Monocyte Differentiation in Vitro | |||||
| 著者 |
中森, 義治
× 中森, 義治 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 134924 | |||||
| 姓名 | Nakamori, Yoshiharu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Changes in arachidonic acid metabolism in human leukemia cells during differerntiation are poorly defined. In this study arachidonic acid metabolites produced by eight different types of leukemia cell lines (HL-60, K-562, KG-1, KU-812, Molt-3, HEL, U-937 and J-111) before and after stimulation with phorbol 12-myristate 13-acetate (PMA) or 1-α, 25-dihydroxy vitamin D_3 in vitro were analyzed using high performance liquid chromatography (HPLC). Some myeloid cell lines (HL-60, K-562, KU-812, J-111 and KG-1) produced PGE_2 through the metabolic pathway of cyclooxygenase by stimulation with arachidonic acid even without differentiation-inducing substances. Interestingly, HL-60 cell line produced high levels of not only PGE_2 but also metabolites such as PGD_2 and TXB_2, suggesting the presence of metabolic pathway of cyclooxygenase which may differ other cell lines. In HL-60, K-562 and KG-1, which are myeloid cell lines, and in J-111, a monocytic leukemia cell line, the production of PGE_2 was increased by treatment with PMA, and morphologically monocyte-like change were observed. On the other hand, treatment with 1-α, 25-dihydroxy vitamin D_3, which has been reported to induce differentiation into granulocytes, caused no increase in PGE_2 production. These results suggest that the cells which differentiate into monocyte-macrophages mainly produce PGE_2 through the metabolic pathway of cyclooxygenase, and their differentiation into granulocytes or lymphocytes is not mediated by cyclooxygenase. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 104, 号 6, p. 487-496, 発行日 1990-06 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
