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悪性黒色腫における基底膜成分およびインテグリンβ_1サブファミリーの免疫組織学的検討
http://hdl.handle.net/10191/38651
http://hdl.handle.net/10191/38651675f0b67-d1e8-4de6-9f87-92a9eb950a4f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
105(3)_177-186.pdf (5.0 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-02-22 | |||||
| タイトル | ||||||
| タイトル | 悪性黒色腫における基底膜成分およびインテグリンβ_1サブファミリーの免疫組織学的検討 | |||||
| タイトル | ||||||
| タイトル | 悪性黒色腫における基底膜成分およびインテグリンβ_1サブファミリーの免疫組織学的検討 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | malignant melanoma | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | basement membrane | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | extracellular matrix | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fibronectin receptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | integrin | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 悪性黒色腫 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 基底膜 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 細胞外物質 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | フィブロネクチンレセプター | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | インテグリン | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Immunohistochemical Alterations of Basement Membrane Components and Fibronectin Receptor in Malignant Melanoma | |||||
| 著者 |
兼子, 泰行
× 兼子, 泰行 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 131623 | |||||
| 姓名 | Kaneko, Yasuyuki | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To investigate alterations in the basement membrane （BM） and of fibronectin receptor （FNR） in malignant melanoma （MM）, the tumor were studied immunohistochemically by double immunofluorescent staining using monoclonal antibodies to the core protein of heparan sulfate proteoglycan（HSPG）, collagen type III（C-3）and chondroitin 6-sulfate （C6S） as well as antiserum to laminin, collagen type IV （C-4）, fibronectin and fibronectin receptor. In MM in situ, C-4, laminin and HSPG were preserved as a continuous linear band on the dermo-epidermal junction （DEJ）, while C6S is extensively lost from the DEJ and fibronectin is remarkably decreased in the papillary dermis compared with the normal skin. In invasive, MM, although the distribution pattern was varied case by case, the BM components were not decreased. The cases were divided into two groups by the distribution pattern; a great amount of each BM component were localized on the surface of tumor cells, or surrounded tumor nests, forming the large nests. In all but one cases examined, however, C6S was absent from the BM zone of the melanoma nests in the dermis. These data indicates that although C6S was absent, the other BM components were actively synthesized by tumor cells, and that the BM components were altered in phase of MM in situ. Intensity of FNR of melanoma cells were generally more fainter than those of infiltrating lymphocytes in the dermis, basal cells of the epidermis and endothelial cells of small vessels. There were no significant differences in their intensity of melanoma cells between each tumor progression phase. Therefore, the present study may reveal that these receptors do not relate to invasion or metastasis of the tumor. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 105, 号 3, p. 177-186, 発行日 1991-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
