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Masked MLL gene rearrangement was disclosed in the clinical course and sequential development of chromosone abnormality in a patient with therapy related acute myelogeneous leukemia
http://hdl.handle.net/10191/1172
http://hdl.handle.net/10191/117245ba78f0-5f69-469b-9b38-cb24ae6e2d43
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
24_0016.pdf (723.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2007-04-23 | |||||
| タイトル | ||||||
| タイトル | Masked MLL gene rearrangement was disclosed in the clinical course and sequential development of chromosone abnormality in a patient with therapy related acute myelogeneous leukemia | |||||
| タイトル | ||||||
| タイトル | Masked MLL gene rearrangement was disclosed in the clinical course and sequential development of chromosone abnormality in a patient with therapy related acute myelogeneous leukemia | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MLL | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | t(9;11) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | secondary leukemia | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | masked chromosomal abnormality | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | monosomy 7 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | journal article | |||||
| 著者 |
Hashimoto, Shigeo
× Hashimoto, Shigeo× Toba, Ken× Izumi, Noriko× Sato, Naoko× Takahashi, Hidenobu× Ozawa, Takuya× Moriyama, Masato× Aoki, Sadao× Furukawa, Tatsuo× Narita, Miwako× Takahashi, Masuhiro× Aizawa, Yoshifusa |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 7254 | |||||
| 姓名 | 鳥羽, 健 | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Therapy related acute myelogenous leukemia in a 55-year-old Japanese woman is described. She had been treated for a diagnosis of non-Hodgkin's lymphoma 2 years before the onset of the secondary leukemia. She was diagnosed as AML (FAB: M2) with monosomy 7, and successfully treated by an intensive combination chemotherapy followed by an autologous peripheral blood stem cell transplantation. The disease relapsed shortly after the treatment, and the karyotype analysis revealed a complex abnormality accompanied with t(9;11)(p22;q23), however, monosomy 7 was absent. Southern blotting analysis was performed, and MLL rearrangement was evident in both the bone marrow samples obtained at that time and the cryopreserved marrow cells obtained at the onset of the disease. The bone marrow sample stored in a Carnoy solution at the onset was further analyzed, and 3 karyotype panels showing 45,XX, -7, t(9;11)(p22;q23) were found. Like this situation, a masked MLL rearrangement may have existed in some cases with hematopoietic malignancies, and appear to be disclosed in the clinical course. | |||||
| 書誌情報 |
Leukemia Research en : Leukemia Research 巻 27, 号 3, p. 285-290, 発行日 2003-03 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 01452126 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00716755 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | info:doi/10.1016/S0145-2126(02)00176-5 | |||||
| 権利 | ||||||
| 権利情報 | Elsevier Ltd | |||||
| 著者版フラグ | ||||||
| 値 | author | |||||
