{"_buckets": {"deposit": "b6aa1914-1ab8-4ba8-a581-ff868cf534e8"}, "_deposit": {"id": "21283", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21283"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021283"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Recent Advances in DIC for Ten Years"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-09", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "9", "bibliographicPageEnd": "638", "bibliographicPageStart": "632", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "To diagnose DIC, we have always been looking for new parameters: e.g. fibrinogen and fibrin degradation products (FDP), antithrombinIII (ATIII), \u03b1_2 plasmin inhibitor (\u03b1_2PI), fibrinmonomer complex (FM) and D dimer (D-D). But these parameters have many problems: FDP can not distinguish between primary fibrinolysis and secondary fibrinolysis. With low plasma levels of ATIII and \u03b1_2PI, we can not see they are due to comsumption or due to reduced production. FM is not quantitative analysis. D-D which is specific for secondary fibrinolygis, is too sensitive to assess secondary fibrinolysis in DIC. We evaluated new molecular markers for the diagnosis of DIC in acute promyelocytic leukemia and other disorders: Thrombin antithrombin III complex (TAT) and plasmin\u30fb\u03b1_2 plasmin inhibitor complex (PIC). TAT and PIC were extremely elevated even though in probable DIC group with DIC scor\u003c4. Abnormal findings of these parameters in probable DIC group seem to show hypercoagulability and fibrinolysis in this group. So plasma levels of TAT and PIC for the diagnosis of DIC should be established. With our data, plasma levels of both TAT\u22677.5\u03bcg/l and PIC\u22672.5\u03bcg/ml, three times of normal value, are valuable for the diagnosis of DIC. Recently the therapy of DIC has greatly advanced using synthetic protease inhibitors and ATIII concentrate.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130317", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Masayuki"}]}, {"nameIdentifiers": [{"nameIdentifier": "130318", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Murakawa, Eizo"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4f50\u85e4, \u6b63\u4e4b"}], "nameIdentifiers": [{"nameIdentifier": "130315", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "\u6751\u5ddd, \u82f1\u4e09"}], "nameIdentifiers": [{"nameIdentifier": "130316", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(9)_632-638.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "105(9)_632-638.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21283/files/105(9)_632-638.pdf"}, "version_id": "157aeb2f-7614-4b5e-9761-b2681d8b06b7"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Disseminated intravascular coagulation (DIC)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Molecular markers for coagulatin and fibrinolysis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Acute promyelocytic leukemia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "therapy of DIC", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u5185\u51dd\u56fa\u75c7\u5019\u7fa4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5206\u5b50\u30de\u30fc\u30ab\u30fc", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6025\u6027\u524d\u9aa8\u9ac4\u7403\u6027\u767d\u8840\u75c5", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6cbb\u7642", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "5) DIC : \u3053\u306e\u5341\u5e74\u9593\u306e\u6b69\u307f(\u65b0\u6f5f\u8840\u6813\u6b62\u8840\u7814\u7a76\u4f1a10\u5468\u5e74\u8a18\u5ff5\u7279\u5225\u4f8b\u4f1a\u8a18\u9332)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "5) DIC : \u3053\u306e\u5341\u5e74\u9593\u306e\u6b69\u307f(\u65b0\u6f5f\u8840\u6813\u6b62\u8840\u7814\u7a76\u4f1a10\u5468\u5e74\u8a18\u5ff5\u7279\u5225\u4f8b\u4f1a\u8a18\u9332)"}, {"subitem_title": "5) DIC : \u3053\u306e\u5341\u5e74\u9593\u306e\u6b69\u307f(\u65b0\u6f5f\u8840\u6813\u6b62\u8840\u7814\u7a76\u4f1a10\u5468\u5e74\u8a18\u5ff5\u7279\u5225\u4f8b\u4f1a\u8a18\u9332)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1182"], "permalink_uri": "http://hdl.handle.net/10191/39392", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-10"}, "publish_date": "2016-03-10", "publish_status": "0", "recid": "21283", "relation": {}, "relation_version_is_last": true, "title": ["5) DIC : \u3053\u306e\u5341\u5e74\u9593\u306e\u6b69\u307f(\u65b0\u6f5f\u8840\u6813\u6b62\u8840\u7814\u7a76\u4f1a10\u5468\u5e74\u8a18\u5ff5\u7279\u5225\u4f8b\u4f1a\u8a18\u9332)"], "weko_shared_id": null}