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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第105巻第10号

新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用

http://hdl.handle.net/10191/39420
00bf7528-5966-41df-96ea-c33acac61aef
名前 / ファイル ライセンス アクション
105(10)_710-724.pdf 105(10)_710-724.pdf (3.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-11
タイトル
タイトル 新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用
タイトル
言語 en
タイトル 新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用
言語
言語 jpn
キーワード
主題Scheme Other
主題 coronary vasodilator
キーワード
主題Scheme Other
主題 adenosine
キーワード
主題Scheme Other
主題 blood flow
キーワード
主題Scheme Other
主題 dipyridamole
キーワード
主題Scheme Other
主題 血管拡張薬
キーワード
主題Scheme Other
主題 アデノシン
キーワード
主題Scheme Other
主題 血流量
キーワード
主題Scheme Other
主題 ジピリダモール
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Pharmacological Properties of 1-[(3, 4-Dihydro-2H-(1, 3)-Thiazino[3, 2-a]Benzimidazole-2-yl)Methyl]-4-(3, 4, 5-Trimethoxycinnamoyl) Piperazine Dihydrochloride (D230), a New Coronary Vasodilating Drug
著者 小川, 陽一郎

× 小川, 陽一郎

WEKO 130257

小川, 陽一郎

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著者別名
識別子
識別子 130258
識別子Scheme WEKO
姓名
姓名 Ogawa, Yoichiro
抄録
内容記述タイプ Abstract
内容記述 The cardiovascular effects of D230 were investigated in comparison with those of dipyridamole. D230 (0.3~3.0 mg/kg i.v.) produced a marked increase in coronary blood flow and a slight decrease in arterial pressure in anesthetized dogs. Concomitant with these changes decrease in total peripheral resistance without tachycardia were noted. Cardiac output and stroke volume increased with no significant changes in cardiac work and myocardial oxygen consumption. D230 potentiated the effect of adenosine. The coronary vasodilating effect of D230 was antagonised by aminophylline. These effects were almost similar to those of dipyridamole (0.1~1.0 mg/kg i.v.). In isolated taenia coli, D230 (10^<-5>~10^<-4>M) caused a partial inhibition of the spontaneous contraction as well as the K+ (30mM and 100mM)-induced contractures. Although D230 did not increase myocardial blood flow of the ischemic region, it tended to suppress the arrhythmias induced by ligation of the left anterior descending coronary artery in anesthetized dogs. D230 (10~30 mg/kg i.v.) depressed the elevation of S wave in electrocardiogram induced by methacholine in rats. These results suggest that similar to that of dipyridamole, the mechanism of the coronary vasodilation induced by D230 may be due to potentiation of action of endogenous adenosine.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 105, 号 10, p. 710-724, 発行日 1991-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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