{"_buckets": {"deposit": "d8ed7cfa-8452-4116-9f4e-921c40e80f4e"}, "_deposit": {"id": "21274", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21274"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021274", "sets": ["456", "1181"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Pharmacological Properties of 1-[(3, 4-Dihydro-2H-(1, 3)-Thiazino[3, 2-a]Benzimidazole-2-yl)Methyl]-4-(3, 4, 5-Trimethoxycinnamoyl) Piperazine Dihydrochloride (D230), a New Coronary Vasodilating Drug"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "724", "bibliographicPageStart": "710", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The cardiovascular effects of D230 were investigated in comparison with those of dipyridamole. D230 (0.3～3.0 mg/kg i.v.) produced a marked increase in coronary blood flow and a slight decrease in arterial pressure in anesthetized dogs. Concomitant with these changes decrease in total peripheral resistance without tachycardia were noted. Cardiac output and stroke volume increased with no significant changes in cardiac work and myocardial oxygen consumption. D230 potentiated the effect of adenosine. The coronary vasodilating effect of D230 was antagonised by aminophylline. These effects were almost similar to those of dipyridamole (0.1～1.0 mg/kg i.v.). In isolated taenia coli, D230 (10^\u003c-5\u003e～10^\u003c-4\u003eM) caused a partial inhibition of the spontaneous contraction as well as the K+ (30mM and 100mM)-induced contractures. Although D230 did not increase myocardial blood flow of the ischemic region, it tended to suppress the arrhythmias induced by ligation of the left anterior descending coronary artery in anesthetized dogs. D230 (10～30 mg/kg i.v.) depressed the elevation of S wave in electrocardiogram induced by methacholine in rats. These results suggest that similar to that of dipyridamole, the mechanism of the coronary vasodilation induced by D230 may be due to potentiation of action of endogenous adenosine.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130258", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ogawa, Yoichiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "小川, 陽一郎"}], "nameIdentifiers": [{"nameIdentifier": "130257", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(10)_710-724.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "105(10)_710-724.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21274/files/105(10)_710-724.pdf"}, "version_id": "1fec05df-d3db-4d5d-8640-6370f7a15c8b"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "coronary vasodilator", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenosine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blood flow", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dipyridamole", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血管拡張薬", "subitem_subject_scheme": "Other"}, {"subitem_subject": "アデノシン", "subitem_subject_scheme": "Other"}, {"subitem_subject": "血流量", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ジピリダモール", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用"}, {"subitem_title": "新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1181"], "permalink_uri": "http://hdl.handle.net/10191/39420", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-11"}, "publish_date": "2016-03-11", "publish_status": "0", "recid": "21274", "relation": {}, "relation_version_is_last": true, "title": ["新冠血管拡張薬, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)の薬理作用"], "weko_shared_id": null}