{"_buckets": {"deposit": "d8ed7cfa-8452-4116-9f4e-921c40e80f4e"}, "_deposit": {"id": "21274", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "21274"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00021274"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Pharmacological Properties of 1-[(3, 4-Dihydro-2H-(1, 3)-Thiazino[3, 2-a]Benzimidazole-2-yl)Methyl]-4-(3, 4, 5-Trimethoxycinnamoyl) Piperazine Dihydrochloride (D230), a New Coronary Vasodilating Drug"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1991-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "724", "bibliographicPageStart": "710", "bibliographicVolumeNumber": "105", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The cardiovascular effects of D230 were investigated in comparison with those of dipyridamole. D230 (0.3\uff5e3.0 mg/kg i.v.) produced a marked increase in coronary blood flow and a slight decrease in arterial pressure in anesthetized dogs. Concomitant with these changes decrease in total peripheral resistance without tachycardia were noted. Cardiac output and stroke volume increased with no significant changes in cardiac work and myocardial oxygen consumption. D230 potentiated the effect of adenosine. The coronary vasodilating effect of D230 was antagonised by aminophylline. These effects were almost similar to those of dipyridamole (0.1\uff5e1.0 mg/kg i.v.). In isolated taenia coli, D230 (10^\u003c-5\u003e\uff5e10^\u003c-4\u003eM) caused a partial inhibition of the spontaneous contraction as well as the K+ (30mM and 100mM)-induced contractures. Although D230 did not increase myocardial blood flow of the ischemic region, it tended to suppress the arrhythmias induced by ligation of the left anterior descending coronary artery in anesthetized dogs. D230 (10\uff5e30 mg/kg i.v.) depressed the elevation of S wave in electrocardiogram induced by methacholine in rats. These results suggest that similar to that of dipyridamole, the mechanism of the coronary vasodilation induced by D230 may be due to potentiation of action of endogenous adenosine.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "130258", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ogawa, Yoichiro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5c0f\u5ddd, \u967d\u4e00\u90ce"}], "nameIdentifiers": [{"nameIdentifier": "130257", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "105(10)_710-724.pdf", "filesize": [{"value": "3.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3200000.0, "url": {"label": "105(10)_710-724.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/21274/files/105(10)_710-724.pdf"}, "version_id": "1fec05df-d3db-4d5d-8640-6370f7a15c8b"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "coronary vasodilator", "subitem_subject_scheme": "Other"}, {"subitem_subject": "adenosine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "blood flow", "subitem_subject_scheme": "Other"}, {"subitem_subject": "dipyridamole", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u62e1\u5f35\u85ac", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a2\u30c7\u30ce\u30b7\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u6d41\u91cf", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b8\u30d4\u30ea\u30c0\u30e2\u30fc\u30eb", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u65b0\u51a0\u8840\u7ba1\u62e1\u5f35\u85ac, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)\u306e\u85ac\u7406\u4f5c\u7528", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u65b0\u51a0\u8840\u7ba1\u62e1\u5f35\u85ac, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)\u306e\u85ac\u7406\u4f5c\u7528"}, {"subitem_title": "\u65b0\u51a0\u8840\u7ba1\u62e1\u5f35\u85ac, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)\u306e\u85ac\u7406\u4f5c\u7528", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1181"], "permalink_uri": "http://hdl.handle.net/10191/39420", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-11"}, "publish_date": "2016-03-11", "publish_status": "0", "recid": "21274", "relation": {}, "relation_version_is_last": true, "title": ["\u65b0\u51a0\u8840\u7ba1\u62e1\u5f35\u85ac, 1-[(3, 4-dihydro-2H-(1, 3)-thiazino[3, 2-a]benzimidazole-2-yl)methyl]-4-(3, 4, 5-trimethoxycinnamoyl) piperazine dihydrochloride(D230)\u306e\u85ac\u7406\u4f5c\u7528"], "weko_shared_id": null}