{"_buckets": {"deposit": "8e8eccd9-ca97-4c3f-8724-6ebc936a4e2b"}, "_deposit": {"id": "20870", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20870"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020870", "sets": ["456", "1172"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Effects of Hemicranial Irradiation on Myelination in the Neonatal Rat"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1992-07", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "7", "bibliographicPageEnd": "625", "bibliographicPageStart": "612", "bibliographicVolumeNumber": "106", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Neonatal rats, aged 4 to 15 days, received single doses of X-irradiation to the right hemicranium. Doses of 5, 7.5, 10 and 15 Gy were administered with linear accelerator. The rats were sacrificed at 14, 21, 28 and 35 days of age and examined for histological changes and immunohistochemically. No remarkable neurological abnormality was noted at the time of sacrifice. With conventional stains there was a dose-dependent decrease in the number of glial cells in the corpus callosum of the irradiated hemisphere, while neurons and blood vessels showed no abnormal changes. Myelin was identified using immunohistochemistry for myelin basic protein and myelin-associated glycoprotein. As compared with unirradiated hemisphere, irradiated hemisphere showed delayed myelination. The antiserum to the large isoform of myelin-associated glycoprotein (L-MAG) stained the cytoplasm of oligodendroglia in 2 to 3 weeks after birth. A smaller number of L-MAG-positive cells were observed in the irradiated hemisphere. This immunohistochemical method appears to be a sensitive histopathological indicator of radiation effect on oligodendroglias. The permeability of the blood-brain barrier (BBB) to sodium fluorescein was investigated and breakdown of the BBB was not observed in the irradiated hemisphere. These results suggest that the delayed myelination in this study was due to a direct radiation effect on oligodendroglias.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "128378", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Sato, Mitsuya"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "佐藤, 光弥"}], "nameIdentifiers": [{"nameIdentifier": "128377", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(07)_612-625.pdf", "filesize": [{"value": "8.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 8100000.0, "url": {"label": "106(07)_612-625.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20870/files/106(07)_612-625.pdf"}, "version_id": "96aa854a-956a-4569-9235-33443ce743c5"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "radiation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "rat", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelination", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelin basic protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myelin-associated glycoprotein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "照射", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ラット", "subitem_subject_scheme": "Other"}, {"subitem_subject": "髄鞘形成", "subitem_subject_scheme": "Other"}, {"subitem_subject": "髄鞘塩基性蛋白", "subitem_subject_scheme": "Other"}, {"subitem_subject": "髄鞘関連糖蛋白", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "脳の放射線障害に関する研究 : ラット頭部半側照射モデルにおけるミエリン形成障害", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "脳の放射線障害に関する研究 : ラット頭部半側照射モデルにおけるミエリン形成障害"}, {"subitem_title": "脳の放射線障害に関する研究 : ラット頭部半側照射モデルにおけるミエリン形成障害", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1172"], "permalink_uri": "http://hdl.handle.net/10191/39833", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-03-17"}, "publish_date": "2016-03-17", "publish_status": "0", "recid": "20870", "relation": {}, "relation_version_is_last": true, "title": ["脳の放射線障害に関する研究 : ラット頭部半側照射モデルにおけるミエリン形成障害"], "weko_shared_id": null}