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However attention was recently focused on an association of extrathymic T cells with various immune response. The liver is a major site for such extrathymic T cell differentiation. Cumulative evidences revealed that extrathymic T cells in the liver comprise cells with TCR of intermediate intensity and contain autoreactive clones. These extrathymic T cells were activated with aging and under conditions of bacterial stimulation and autoimmune diseases. In the present study, it was investigated how regular T cells were activated in mice injected with viable syngeneic tumors. It was demonstrated that specific activation of extrathymic T cells in the liver and acquisition of anti-tumor cytotoxicity were induced in these mice. The present results suggested that extrathymic T cells played an important role on tumor immunity in the host-defense mechanisms.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "126656", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ohmori, Katsutoshi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u5927\u68ee, \u514b\u5229"}], "nameIdentifiers": [{"nameIdentifier": "126655", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "106(12)_1129-1137.pdf", "filesize": [{"value": "1.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1400000.0, "url": {"label": "106(12)_1129-1137.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20522/files/106(12)_1129-1137.pdf"}, "version_id": "761a3f3d-f3b3-439a-8937-954c326f5bf7"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Extrathymic T cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Anti-tumor cytotoxicity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "MCA105", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u80f8\u817a\u5916\u5206\u5316T\u7d30\u80de", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u6297\u816b\u760d\u6d3b\u6027", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u816b\u760d\u514d\u75ab\u306b\u5bfe\u3059\u308b\u80f8\u817a\u5916T\u7d30\u80de\u5206\u5316\u7d4c\u8def\u306e\u95a2\u4e0e : \u540c\u7cfb\u816b\u760d\u62c5\u764c\u6642\u306e\u809d\u5185\u80f8\u817a\u5916\u5206\u5316\u7d4c\u8def\u306e\u7279\u7570\u7684\u6d3b\u6027\u5316\u3068\u6297\u816b\u760d\u6d3b\u6027\u306e\u691c\u8a0e", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u816b\u760d\u514d\u75ab\u306b\u5bfe\u3059\u308b\u80f8\u817a\u5916T\u7d30\u80de\u5206\u5316\u7d4c\u8def\u306e\u95a2\u4e0e : \u540c\u7cfb\u816b\u760d\u62c5\u764c\u6642\u306e\u809d\u5185\u80f8\u817a\u5916\u5206\u5316\u7d4c\u8def\u306e\u7279\u7570\u7684\u6d3b\u6027\u5316\u3068\u6297\u816b\u760d\u6d3b\u6027\u306e\u691c\u8a0e"}, {"subitem_title": "\u816b\u760d\u514d\u75ab\u306b\u5bfe\u3059\u308b\u80f8\u817a\u5916T\u7d30\u80de\u5206\u5316\u7d4c\u8def\u306e\u95a2\u4e0e : \u540c\u7cfb\u816b\u760d\u62c5\u764c\u6642\u306e\u809d\u5185\u80f8\u817a\u5916\u5206\u5316\u7d4c\u8def\u306e\u7279\u7570\u7684\u6d3b\u6027\u5316\u3068\u6297\u816b\u760d\u6d3b\u6027\u306e\u691c\u8a0e", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1167"], "permalink_uri": "http://hdl.handle.net/10191/40235", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-25"}, "publish_date": "2016-03-25", "publish_status": "0", "recid": "20522", "relation": {}, "relation_version_is_last": true, "title": ["\u816b\u760d\u514d\u75ab\u306b\u5bfe\u3059\u308b\u80f8\u817a\u5916T\u7d30\u80de\u5206\u5316\u7d4c\u8def\u306e\u95a2\u4e0e : \u540c\u7cfb\u816b\u760d\u62c5\u764c\u6642\u306e\u809d\u5185\u80f8\u817a\u5916\u5206\u5316\u7d4c\u8def\u306e\u7279\u7570\u7684\u6d3b\u6027\u5316\u3068\u6297\u816b\u760d\u6d3b\u6027\u306e\u691c\u8a0e"], "weko_shared_id": null}