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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第106巻第12号

腫瘍免疫に対する胸腺外T細胞分化経路の関与 : 同系腫瘍担癌時の肝内胸腺外分化経路の特異的活性化と抗腫瘍活性の検討

http://hdl.handle.net/10191/40235
http://hdl.handle.net/10191/40235
aca67cd9-4970-4725-b6bd-e04f7fcb3a25
名前 / ファイル ライセンス アクション
106(12)_1129-1137.pdf 106(12)_1129-1137.pdf (1.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-25
タイトル
タイトル 腫瘍免疫に対する胸腺外T細胞分化経路の関与 : 同系腫瘍担癌時の肝内胸腺外分化経路の特異的活性化と抗腫瘍活性の検討
タイトル
言語 en
タイトル 腫瘍免疫に対する胸腺外T細胞分化経路の関与 : 同系腫瘍担癌時の肝内胸腺外分化経路の特異的活性化と抗腫瘍活性の検討
言語
言語 jpn
キーワード
主題Scheme Other
主題 Extrathymic T cells
キーワード
主題Scheme Other
主題 Anti-tumor cytotoxicity
キーワード
主題Scheme Other
主題 MCA105
キーワード
主題Scheme Other
主題 胸腺外分化T細胞
キーワード
主題Scheme Other
主題 抗腫瘍活性
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Association of Extrathymic Pathway of T Cell Differentiation with Anti-tumor Immunity : Specific Activation of the Hepatic Extrathymic Pathway and Analysis of Anti-tumor Cytotoxicity in Mice Bearing with Syngeneic Tumors
著者 大森, 克利

× 大森, 克利

WEKO 126655

大森, 克利

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著者別名
識別子 126656
識別子Scheme WEKO
姓名 Ohmori, Katsutoshi
抄録
内容記述タイプ Abstract
内容記述 The thymus is the major central organ for T cell differentiation in the body. However attention was recently focused on an association of extrathymic T cells with various immune response. The liver is a major site for such extrathymic T cell differentiation. Cumulative evidences revealed that extrathymic T cells in the liver comprise cells with TCR of intermediate intensity and contain autoreactive clones. These extrathymic T cells were activated with aging and under conditions of bacterial stimulation and autoimmune diseases. In the present study, it was investigated how regular T cells were activated in mice injected with viable syngeneic tumors. It was demonstrated that specific activation of extrathymic T cells in the liver and acquisition of anti-tumor cytotoxicity were induced in these mice. The present results suggested that extrathymic T cells played an important role on tumor immunity in the host-defense mechanisms.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 106, 号 12, p. 1129-1137, 発行日 1992-12
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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