{"_buckets": {"deposit": "5d7057a4-5987-440c-b6c0-ed9d500cb7f5"}, "_deposit": {"id": "2050", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "2050"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00002050", "sets": ["454", "484"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2006-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "638", "bibliographicPageStart": "629", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Journal of Molecular and Cellular Cardiology"}, {"bibliographic_title": "Journal of Molecular and Cellular Cardiology", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Bone marrow cell implantation (BMI) has been utilized to treat patients with limb and heart ischemia. BMI provides angiogenic precursors and angiogenic cytokine-producing cells, especially erythroid cells. In this study, we induced in vitro angiogenesis cultures and in vivo BMI simulation using a murine limb ischemia model to examine the role of erythroid cells and the effect of erythropoietin (EPO). Human erythroid colonies (BFU-e) induced capillary networks around the colonies in vitro. Erythroid cells in human bone marrow produced vascular endothelial growth factor and placental growth factor. The angiogenic effects of erythroid cells were further amplified in the presence of EPO. Limb-ischemic mice were treated with BMI ± EPO, and limb survival, blood flow recovery, and muscle histology were analyzed. Treatment with whole bone marrow cells + EPO significantly improved limb survival and blood flow. The cumulative effects of EPO on BMI induced and increase in capillary number and artery enlargement. Erythroid cells were essential for the in vivo effects of BMI, and CD14-positive cells supported the biological effects. In addition to the direct effect of EPO on angiogenesis, EPO showed indirect effect on angiogenesis through amplifying the angiogenic effects by erythroid cells supported by CD14-positive cells.", "subitem_description_type": "Abstract"}]}, "item_5_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "6775", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "鳥羽, 健"}]}]}, "item_5_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_5_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "info:doi/10.1016/j.yjmcc.2006.01.023", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Elsevier Ltd"}]}, "item_5_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00702819", "subitem_source_identifier_type": "NCID"}]}, "item_5_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00222828", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ozawa, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "6761", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Toba, Ken"}], "nameIdentifiers": [{"nameIdentifier": "6762", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Kiminori"}], "nameIdentifiers": [{"nameIdentifier": "6763", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minagawa, Shiro"}], "nameIdentifiers": [{"nameIdentifier": "6764", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saigawa, Takashi"}], 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"6772", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Masuhiro"}], "nameIdentifiers": [{"nameIdentifier": "6773", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aizawa, Yoshifusa"}], "nameIdentifiers": [{"nameIdentifier": "6774", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-07-29"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "24_0008.pdf", "filesize": [{"value": "2.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2800000.0, "url": {"label": "24_0008.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/2050/files/24_0008.pdf"}, "version_id": "c3d0ae14-9cd4-4162-adfd-f697bcd0ff36"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "angiogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "growth factors", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ischemia", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation"}, {"subitem_title": "Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "1", "path": ["454", "484"], "permalink_uri": "http://hdl.handle.net/10191/1167", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-04-23"}, "publish_date": "2007-04-23", "publish_status": "0", "recid": "2050", "relation": {}, "relation_version_is_last": true, "title": ["Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation"], "weko_shared_id": null}