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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 300 医歯学総合病院
  2. 10 学術雑誌論文
  3. 10 査読済論文

Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation

http://hdl.handle.net/10191/1167
http://hdl.handle.net/10191/1167
b630ba47-4ae7-4377-a976-171d035ff36c
名前 / ファイル ライセンス アクション
24_0008.pdf 24_0008.pdf (2.8 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-23
タイトル
タイトル Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation
タイトル
言語 en
タイトル Erythroid cells play essential roles in angiogenesis by bone marrow cell implantation
言語
言語 eng
キーワード
主題Scheme Other
主題 angiogenesis
キーワード
主題Scheme Other
主題 growth factors
キーワード
主題Scheme Other
主題 ischemia
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ozawa, Takuya

× Ozawa, Takuya

WEKO 6761

Ozawa, Takuya

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Toba, Ken

× Toba, Ken

WEKO 6762

Toba, Ken

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Kato, Kiminori

× Kato, Kiminori

WEKO 6763

Kato, Kiminori

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Minagawa, Shiro

× Minagawa, Shiro

WEKO 6764

Minagawa, Shiro

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Saigawa, Takashi

× Saigawa, Takashi

WEKO 6765

Saigawa, Takashi

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Hanawa, Haruo

× Hanawa, Haruo

WEKO 6766

Hanawa, Haruo

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Makiyama, Yasuhiro

× Makiyama, Yasuhiro

WEKO 6767

Makiyama, Yasuhiro

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Moriyama, Masato

× Moriyama, Masato

WEKO 6768

Moriyama, Masato

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Honma, Kei-Ichiro

× Honma, Kei-Ichiro

WEKO 6769

Honma, Kei-Ichiro

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Isoda, Manabu

× Isoda, Manabu

WEKO 6770

Isoda, Manabu

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Hasegawa, Go

× Hasegawa, Go

WEKO 6771

Hasegawa, Go

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Naito, Makoto

× Naito, Makoto

WEKO 6772

Naito, Makoto

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Takahashi, Masuhiro

× Takahashi, Masuhiro

WEKO 6773

Takahashi, Masuhiro

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Aizawa, Yoshifusa

× Aizawa, Yoshifusa

WEKO 6774

Aizawa, Yoshifusa

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著者別名
識別子 6775
識別子Scheme WEKO
姓名 鳥羽, 健
抄録
内容記述タイプ Abstract
内容記述 Bone marrow cell implantation (BMI) has been utilized to treat patients with limb and heart ischemia. BMI provides angiogenic precursors and angiogenic cytokine-producing cells, especially erythroid cells. In this study, we induced in vitro angiogenesis cultures and in vivo BMI simulation using a murine limb ischemia model to examine the role of erythroid cells and the effect of erythropoietin (EPO). Human erythroid colonies (BFU-e) induced capillary networks around the colonies in vitro. Erythroid cells in human bone marrow produced vascular endothelial growth factor and placental growth factor. The angiogenic effects of erythroid cells were further amplified in the presence of EPO. Limb-ischemic mice were treated with BMI ± EPO, and limb survival, blood flow recovery, and muscle histology were analyzed. Treatment with whole bone marrow cells + EPO significantly improved limb survival and blood flow. The cumulative effects of EPO on BMI induced and increase in capillary number and artery enlargement. Erythroid cells were essential for the in vivo effects of BMI, and CD14-positive cells supported the biological effects. In addition to the direct effect of EPO on angiogenesis, EPO showed indirect effect on angiogenesis through amplifying the angiogenic effects by erythroid cells supported by CD14-positive cells.
書誌情報 Journal of Molecular and Cellular Cardiology
en : Journal of Molecular and Cellular Cardiology

巻 40, 号 5, p. 629-638, 発行日 2006-05
出版者
出版者 Elsevier
ISSN
収録物識別子タイプ ISSN
収録物識別子 00222828
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00702819
DOI
識別子タイプ DOI
関連識別子 info:doi/10.1016/j.yjmcc.2006.01.023
権利
権利情報 Elsevier Ltd
著者版フラグ
値 author
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