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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第107巻第2号

3) アルツハイマー病研究の動向(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)

http://hdl.handle.net/10191/37191
http://hdl.handle.net/10191/37191
80c8afd3-8617-4801-85de-2e236487c409
名前 / ファイル ライセンス アクション
107(2)_111-116.pdf 107(2)_111-116.pdf (1.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-01-25
タイトル
タイトル 3) アルツハイマー病研究の動向(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)
タイトル
言語 en
タイトル 3) アルツハイマー病研究の動向(シンポジウム 老年痴呆の諸問題, 第468回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 Alzheimer's disease
キーワード
主題Scheme Other
主題 β-protein
キーワード
主題Scheme Other
主題 tau-protein protein kinase C
キーワード
主題Scheme Other
主題 neurotrophic factor
キーワード
主題Scheme Other
主題 アルツハイマー病
キーワード
主題Scheme Other
主題 β-蛋白
キーワード
主題Scheme Other
主題 タウ蛋白
キーワード
主題Scheme Other
主題 プロテインキナーゼC
キーワード
主題Scheme Other
主題 神経栄養因子
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Recent Advances in The Research of Alzheimer's Disease(Senile Dementia of Alzheimer Type)
著者 柳澤, 勝彦

× 柳澤, 勝彦

WEKO 125734

柳澤, 勝彦

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著者別名
識別子 125735
識別子Scheme WEKO
姓名 Yanagisawa, Katsuhiko
抄録
内容記述タイプ Abstract
内容記述 Pathological hallmarks of Alzheimer's disease (AD) are neuritic plaques and neurofibrillary tangles (NFT). Biochemical studies on AD have been based on these pathological features. The amyloid fibrils in plaques consist of polymers of a 4 kDa protein subunit, β-protein. The β-protein is a cleaved product from a precursor protein (APP). Neither the cellular origin of the amyloid nor the mechanism of amyloid accumulation is understood. Involvement of fetal type phosphorylation and fetal type cytoskeletal protein in the formation of paired helical filament, component of NFT, is another important aspect, suggesting that there is some regenerating process in AD brains. Recently lack of growth inhibitory activity was found in AD brains. This biochemical finding may be important to unravel the mechanism of regenerating process in AD brains. Altered protein kinase was found in AD brains. The abnormality in phosphorylation may be related to the expression of some biochemical characteristics like amyloid accumulation or PHF formation. The research on AD has been also advanced with molecular genetics. Very recently Hardy and his colleague found point mutation in APP gene. The pathological significance of this mutation will be elucidated in the near future.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 107, 号 2, p. 111-116, 発行日 1993-02
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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