WEKO3
-
RootNode
アイテム
高血圧と心不全の心筋内カテコラミンとα1, β1, Ca^<2＋>受容体について
http://hdl.handle.net/10191/37336
http://hdl.handle.net/10191/37336b9e38792-188c-404c-aa13-d1ef0251013d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
107(4)_336-349.pdf (3.2 MB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-02-02 | |||||
| タイトル | ||||||
| タイトル | 高血圧と心不全の心筋内カテコラミンとα1, β1, Ca^<2＋>受容体について | |||||
| タイトル | ||||||
| タイトル | 高血圧と心不全の心筋内カテコラミンとα1, β1, Ca^<2＋>受容体について | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Catecholamine | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-adrenoceptor | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Xamoterol | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | dibutyryl cyclic AMP | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | heart failure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | hypertension | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cardiomyopathy | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | カテコラミン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β受容体 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ザモテロール | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ブクラデシン | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 心不全 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 高血圧 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 心筋症 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Cardiac Catecholamine Concentrations and α1, β1, Ca^<2+>-Receptors in Patients of Hypertension or Heart Failure | |||||
| 著者 |
渡辺, 賢一
× 渡辺, 賢一 |
|||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 124984 | |||||
| 姓名 | Watanabe, Kenichi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | An improved high performance liquid chromatographic procedure useing an electrochemical detector (HPLC-ECD) for the analysis of catecholamine in tissue is described. The separation of norepinephrine (NE), epinephrine (E), dopamine (DA) and 3, 4-dihydroxybenzylamine (internal standard) was achieved within 14min. Detection limits were 5 pg fbr NE, 15 pg for E and 20 pg for DA at a signal to noise ratio of 3, respectively. The recovery of these catecholamines eluted from the alumina was above 80% . Useing this method, the determination of cardiac catecholamine concentrations of Wistar-kyoto rat (WKY) and the spontaneously hypertensive rat (SHR) was carried out. In fetus of WKY and SHR, cardiac E concentration was high. With the growth of rats, cardiac E concentration went down, while a rapid increase of cardiac NE concentration appeared. Cardiac NE concentration of SHR became higher than that of WKY significantly in 16 week-old rats and cardiac NE concentration of pregnant SHR was higher than that of 16 week-old SHIR. Cardiac NE was lower in cardiomyopathic hamster (BIO 14.6) than in the control hamster. Coenzyme Q_10 was administered orally for 10 months tended to increase cardiac NE in cardiomyopathic hamster. These findings confirm the protective effect of Coenzyme Q_10 in myocardium of idiopathic dilated cardiomyopathy patients. Xamoterol, a β_1-partial agonist, was given orally for 7 days (100mg twice daily) to healthy volunteers and patients with heart failure. Lymphocyte β-receptor density (Bmax) and affinity were determined by radioligand binding assay using ^<125>I-ICYP berore and after the treatment. Bmax was lower in the patient group compared with control group. During treatment with xamoterol, Bmax increased markedly in both groups. Following withdrawal of the treament, Bmax deceased in both groups. Blood pressure rose slightiy in both groups. The ling-term effects after 3 and 12 months of treatment with xsmoterol were assessed. Xamoterol increased exercised tolerance after 12 months of treatment. Echocardiographic fractional shortening increased and pulmonary wedge pressure (PAW) during exercise at the same work load decreased at 3 months. Resting PAW and exercise heart rate decreased at 3 months. The density of the βーreceptors in lymphocytes increased at 3 and 12 months. | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate the mechanism by which the new inotropic agent dibutyryl cyclic AMP (DBcAMP) improves the cardiac functon, I examined multiple indices of the left ventricular systolic and diastolic functions before and during administration of DBcAMP to patients with congestive heart failure (CHF, NYHA II-IV). In 12 patients echocardiographic and radionuclide angiographic studies were performed during right heart catheterization. During intravenous administration of DBcAmP, there were no significant changes in the heart rate, left ventricular dimension, right ventricular ejection fraction, left ventricular peak systolic ejection rate. Left ventricular ejection fraction, left ventricular peak diastolic filling rate and cardiac index increased significantly during DBcAMP. Additionally, blood pressure, mean pulmonary wedge pressure and total peripheral vascular resisance decreaed significantly. In conclusion, an improved method for the determination of cardiac catechlamines by HPLC-ECD is presented. The relation between the progression of the hypertension or pregnant-toxicosis and cardiac catecholamine concentraions was strongly suggested. β-receptor in myocardium was lower in CHF compared with control. Xamoterol demonstrated both β-agonist and antagonist effects in CHF and DCM patients. β-receptors in lymphocytes were up-regurated during treatment with xamoterol without deterioration in cardiac function in the patient with CHF. DBcAMP improved systolic and diastolic functions in patients with CHF. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 107, 号 4, p. 336-349, 発行日 1993-04 |
|||||
| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
Share
Cite as
渡辺, 賢一, 1993, 高血圧と心不全の心筋内カテコラミンとα1, β1, Ca^<2＋>受容体について: 新潟医学会, 336–349 p.
Loading...
