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Cisplatin腎障害における尿中グアニジノ酢酸の動態
http://hdl.handle.net/10191/37460
aabeee69-192f-4868-80fb-456d67fcb3e2
名前 / ファイル | ライセンス | アクション | |
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-02-03 | |||||
タイトル | ||||||
タイトル | Cisplatin腎障害における尿中グアニジノ酢酸の動態 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cisplatin腎障害における尿中グアニジノ酢酸の動態 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GAA | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NAG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | BMG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CDDP nephropathy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | グアニジニノ酢酸 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NAG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | β_2 ミクログロブリン | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | シスプラチン腎障害 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Urinary Excretion of Guanidinoacetic Acid in Cisplatin Nephropathy | |||||
著者 |
田崎, 和之
× 田崎, 和之 |
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著者別名 | ||||||
識別子 | ||||||
識別子 | 124474 | |||||
識別子Scheme | WEKO | |||||
姓名 | ||||||
姓名 | Tasaki, Kazuyuki | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | This study was attempted to evaluate the nephrotoxicity of Cisplatin (CDDP) in 10 lung cancer patients by urinary excretion of guanidinoacetic acid (GAA) , which was produced mainly in the renal proximal tubules by transamidination of glycine from arginine. The urine concentration of N-acetyl-β-glucosaminidase (NAG) and β_2-microglobulin (BMG) was also compared with that of GAA. The urine level of GAA, NAG, and BMG (U-GAA, U-NAG, U-BMG) was measured by high performance liquid chromatography (HPLC), enzyme immunoassay, and latex agglutination method respectively. The serum creatinine level had a significant negative correlation with urinary excretion of GAA (r=-0.35, p<0.05). After administration of CDDP, U-GAA decreased significantly on day 0, 3, 7, 10 and 14. Similarly, U-NAG increased on day 3, 7, and U-BMG on day 0, 1. However, these changes were less prominent than that of U-GAA. The further studies of long-term treated 3 cases revealed that U-GAA was a more sensitive marker than U-NAG or U-BMG in CDDP nephropathy. These findings suggest that U-GAA is extremely useful for early detection of CDDP nephropathy. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 107, 号 6, p. 523-532, 発行日 1993-06 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |