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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第107巻第6号

Cisplatin腎障害における尿中グアニジノ酢酸の動態

http://hdl.handle.net/10191/37460
http://hdl.handle.net/10191/37460
aabeee69-192f-4868-80fb-456d67fcb3e2
名前 / ファイル ライセンス アクション
107(6)_523-532.pdf 107(6)_523-532.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-03
タイトル
タイトル Cisplatin腎障害における尿中グアニジノ酢酸の動態
タイトル
言語 en
タイトル Cisplatin腎障害における尿中グアニジノ酢酸の動態
言語
言語 jpn
キーワード
主題Scheme Other
主題 GAA
キーワード
主題Scheme Other
主題 NAG
キーワード
主題Scheme Other
主題 BMG
キーワード
主題Scheme Other
主題 CDDP nephropathy
キーワード
主題Scheme Other
主題 グアニジニノ酢酸
キーワード
主題Scheme Other
主題 NAG
キーワード
主題Scheme Other
主題 β_2 ミクログロブリン
キーワード
主題Scheme Other
主題 シスプラチン腎障害
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Urinary Excretion of Guanidinoacetic Acid in Cisplatin Nephropathy
著者 田崎, 和之

× 田崎, 和之

WEKO 124473

田崎, 和之

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著者別名
識別子 124474
識別子Scheme WEKO
姓名 Tasaki, Kazuyuki
抄録
内容記述タイプ Abstract
内容記述 This study was attempted to evaluate the nephrotoxicity of Cisplatin (CDDP) in 10 lung cancer patients by urinary excretion of guanidinoacetic acid (GAA) , which was produced mainly in the renal proximal tubules by transamidination of glycine from arginine. The urine concentration of N-acetyl-β-glucosaminidase (NAG) and β_2-microglobulin (BMG) was also compared with that of GAA. The urine level of GAA, NAG, and BMG (U-GAA, U-NAG, U-BMG) was measured by high performance liquid chromatography (HPLC), enzyme immunoassay, and latex agglutination method respectively. The serum creatinine level had a significant negative correlation with urinary excretion of GAA (r=-0.35, p<0.05). After administration of CDDP, U-GAA decreased significantly on day 0, 3, 7, 10 and 14. Similarly, U-NAG increased on day 3, 7, and U-BMG on day 0, 1. However, these changes were less prominent than that of U-GAA. The further studies of long-term treated 3 cases revealed that U-GAA was a more sensitive marker than U-NAG or U-BMG in CDDP nephropathy. These findings suggest that U-GAA is extremely useful for early detection of CDDP nephropathy.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 107, 号 6, p. 523-532, 発行日 1993-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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