{"_buckets": {"deposit": "8201224b-0409-4321-90fd-b7a3ba03ad34"}, "_deposit": {"id": "20122", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "20122"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00020122"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Urinary Excretion of Guanidinoacetic Acid in Cisplatin Nephropathy"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "532", "bibliographicPageStart": "523", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "This study was attempted to evaluate the nephrotoxicity of Cisplatin (CDDP) in 10 lung cancer patients by urinary excretion of guanidinoacetic acid (GAA) , which was produced mainly in the renal proximal tubules by transamidination of glycine from arginine. The urine concentration of N-acetyl-\u03b2-glucosaminidase (NAG) and \u03b2_2-microglobulin (BMG) was also compared with that of GAA. The urine level of GAA, NAG, and BMG (U-GAA, U-NAG, U-BMG) was measured by high performance liquid chromatography (HPLC), enzyme immunoassay, and latex agglutination method respectively. The serum creatinine level had a significant negative correlation with urinary excretion of GAA (r=-0.35, p\u003c0.05). After administration of CDDP, U-GAA decreased significantly on day 0, 3, 7, 10 and 14. Similarly, U-NAG increased on day 3, 7, and U-BMG on day 0, 1. However, these changes were less prominent than that of U-GAA. The further studies of long-term treated 3 cases revealed that U-GAA was a more sensitive marker than U-NAG or U-BMG in CDDP nephropathy. These findings suggest that U-GAA is extremely useful for early detection of CDDP nephropathy.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "124474", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Tasaki, Kazuyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u7530\u5d0e, \u548c\u4e4b"}], "nameIdentifiers": [{"nameIdentifier": "124473", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "107(6)_523-532.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "107(6)_523-532.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/20122/files/107(6)_523-532.pdf"}, "version_id": "01565700-74c3-4029-a97e-1ae0e1436ee0"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "GAA", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NAG", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BMG", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CDDP nephropathy", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b0\u30a2\u30cb\u30b8\u30cb\u30ce\u9162\u9178", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NAG", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u03b2_2 \u30df\u30af\u30ed\u30b0\u30ed\u30d6\u30ea\u30f3", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b7\u30b9\u30d7\u30e9\u30c1\u30f3\u814e\u969c\u5bb3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Cisplatin\u814e\u969c\u5bb3\u306b\u304a\u3051\u308b\u5c3f\u4e2d\u30b0\u30a2\u30cb\u30b8\u30ce\u9162\u9178\u306e\u52d5\u614b", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Cisplatin\u814e\u969c\u5bb3\u306b\u304a\u3051\u308b\u5c3f\u4e2d\u30b0\u30a2\u30cb\u30b8\u30ce\u9162\u9178\u306e\u52d5\u614b"}, {"subitem_title": "Cisplatin\u814e\u969c\u5bb3\u306b\u304a\u3051\u308b\u5c3f\u4e2d\u30b0\u30a2\u30cb\u30b8\u30ce\u9162\u9178\u306e\u52d5\u614b", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1161"], "permalink_uri": "http://hdl.handle.net/10191/37460", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-02-03"}, "publish_date": "2016-02-03", "publish_status": "0", "recid": "20122", "relation": {}, "relation_version_is_last": true, "title": ["Cisplatin\u814e\u969c\u5bb3\u306b\u304a\u3051\u308b\u5c3f\u4e2d\u30b0\u30a2\u30cb\u30b8\u30ce\u9162\u9178\u306e\u52d5\u614b"], "weko_shared_id": null}