WEKO3
アイテム
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The aim of the current study was to analyze the developmental change in the gene expression of myostatin and an adipogenic transcription factor (peroxisome proliferator-activated receptor λ2) in the semitendinosus muscle of Japanese Black Cattle throughout the whole life cycle. An additional aim was to compare the temporal expression patterns of myostatin and relevant myogenic regulatory factors (MRF) mRNA during muscle regeneration after frostbite injury at 16 mo of age. The developmental pattern of myostatin gene expression exhibited 2 peaks: the greatest expression occurred in utero (P \u003c0.05) and the second greatest occurred at 16 mo of age (P \u003c0.05). The greatest level of peroxisome proliferator-activated receptor λ2 expression was observed at 16 mo of age (P \u003c0.05), which paralleled myostatin expression. During frostbite-induced muscle regeneration, gene expression for myostatin and 4 MRF; i.e., Myf5, MyoD, myogenin and MRF4, showed contrasting responses. 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Gene expression of myostatin during development and regeneration of skeletal muscle in Japanese Black Cattle
http://hdl.handle.net/10191/29626
http://hdl.handle.net/10191/29626be634240-6c6f-4278-ae36-cfa5e0f7e41e
名前 / ファイル | ライセンス | アクション |
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JAS_84(11)_2983-2989.pdf (352.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-08-20 | |||||
タイトル | ||||||
タイトル | Gene expression of myostatin during development and regeneration of skeletal muscle in Japanese Black Cattle | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Gene expression of myostatin during development and regeneration of skeletal muscle in Japanese Black Cattle | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | beef cattle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myogenic regulatory factor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | myostatin, | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | peroxisome proliferator-activated receptor γ 2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | regeneration | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Shibata, M.
× Shibata, M.× Matsumoto, K.× Aikawa, K.× Muramoto, T.× Fujimura, S.× Kadowaki, M. |
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著者別名 | ||||||
識別子 | 6555 | |||||
識別子Scheme | WEKO | |||||
姓名 | Kadowaki, Motoni | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Myostatin is a specific negative regulator of skeletal muscle growth and is regarded as one of the most important factors for myogenesis. The aim of the current study was to analyze the developmental change in the gene expression of myostatin and an adipogenic transcription factor (peroxisome proliferator-activated receptor λ2) in the semitendinosus muscle of Japanese Black Cattle throughout the whole life cycle. An additional aim was to compare the temporal expression patterns of myostatin and relevant myogenic regulatory factors (MRF) mRNA during muscle regeneration after frostbite injury at 16 mo of age. The developmental pattern of myostatin gene expression exhibited 2 peaks: the greatest expression occurred in utero (P <0.05) and the second greatest occurred at 16 mo of age (P <0.05). The greatest level of peroxisome proliferator-activated receptor λ2 expression was observed at 16 mo of age (P <0.05), which paralleled myostatin expression. During frostbite-induced muscle regeneration, gene expression for myostatin and 4 MRF; i.e., Myf5, MyoD, myogenin and MRF4, showed contrasting responses. Myostatin mRNA dramatically declined by 68.1 and 82.6% at 3 and 5 d after injury (P <0.05), respectively, which paralleled its protein expression, and was restored at 10 d. In contrast, the expressions of all 4 MRF mRNA were low initially but increased by 5 d after injury (P <0.05) and then remained constant or decreased slightly. These results suggest that myostatin may play a role in muscle marbling in the fattening period by decreasing myogenesis and increasing adipogenesis, and that the interaction between myostatin and MRF genes may take place at an early stage of skeletal muscle regeneration. | |||||
書誌情報 |
Journal of Animal Science en : Journal of Animal Science 巻 84, 号 11, p. 2983-2989, 発行日 2006-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00218812 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00693263 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.2527/jas.2006-118 | |||||
権利 | ||||||
権利情報 | ©2006 American Society of Animal Science | |||||
著者版フラグ | ||||||
値 | publisher |