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日本の視神経低形成患者における中枢神経異常合併頻度
http://hdl.handle.net/10191/0002000856
http://hdl.handle.net/10191/0002000856b74b8a84-4bb6-469f-a67d-598a5df1d46c
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本文 (2.44MB)
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要旨 (560KB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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公開日 | 2023-03-07 | |||||||||
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言語 | en | |||||||||
タイトル | The Prevalence of Brain Abnormalities in Japanese Patients with Optic Nerve Hypoplasia | |||||||||
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言語 | ja | |||||||||
タイトル | 日本の視神経低形成患者における中枢神経異常合併頻度 | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Optic nerve hypoplasia | |||||||||
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言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | magnetic resonance | |||||||||
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言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | imaging; brain abnormality | |||||||||
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言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | septo-optic dysplasia | |||||||||
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言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | pituitary hypofunction | |||||||||
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資源 | http://purl.org/coar/resource_type/c_db06 | |||||||||
タイプ | doctoral thesis | |||||||||
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アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
著者 |
清河, 慈
× 清河, 慈
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内容記述タイプ | Abstract | |||||||||
内容記述 | The purpose of this study was to investigate the clinical characteristics of Japanese patients with optic nerve hypoplasia (ONH), with particular attention to the prevalence of brain abnormalities. We retrospectively analysed the medical charts of 16 patients who were diagnosed with ONH and who underwent magnetic resonance imaging (MRI) at Niigata University Medical and Dental Hospital. We recorded the age, sex, laterality, initial eye and visual symptoms, best-corrected visual acuity, and brain abnormalities on MRI (excluding ONH). The median age at the first visit to the Ophthalmology Clinic was 2.4 years old. Four patients were male and 12 were female. ONH was bilateral in 11 patients and unilateral in five. Best-corrected visual acuity ranged from no light perception to 20/20. Seven patients (43.8%) had brain abnormalities including agenesis of the septum pellucidum, pituitary gland hypofunction, cerebral dysplasia, and West syndrome. Five of these seven patients had general manifestations since the neonatal or infantile period. Our study revealed the prevalence of brain abnormalities associated with optic nerve hypoplasia in Japanese patients at a single institute. Because two of 11 patients had no general manifestations since the neonatal or infantile period but demonstrated brain abnormalities, MRI should be performed to investigate all patients with ONH. | |||||||||
言語 | en | |||||||||
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内容記述タイプ | Other | |||||||||
内容記述 | Neuro-ophthalmology. 2021, 45(4), 265-270. | |||||||||
言語 | en | |||||||||
DOI | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1080/01658107.2020.1844758 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | © 2021 Taylor & Francis Group, LLC | |||||||||
学位名 | ||||||||||
言語 | ja | |||||||||
学位名 | 博士(医学) | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関識別子 | 13101 | |||||||||
言語 | ja | |||||||||
学位授与機関名 | 新潟大学 | |||||||||
言語 | en | |||||||||
学位授与機関名 | Niigata University | |||||||||
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学位授与年月日 | 2022-03-23 | |||||||||
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学位授与番号 | 甲第5000号 | |||||||||
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内容記述タイプ | Other | |||||||||
内容記述 | 新大院博(医)第1070号 | |||||||||
言語 | ja |