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アイテム
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抗PD-1抗体治療はリンパ球除去とT細胞移入という養子免疫療法による抗腫瘍効果を高増強する
http://hdl.handle.net/10191/0002000837
http://hdl.handle.net/10191/00020008374be660a0-9d4b-44f0-adbf-f21aa9693023
名前 / ファイル | ライセンス | アクション |
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
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公開日 | 2023-03-07 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | PD‑1 blockade therapy augments the antitumor effects of lymphodepletion and adoptive T cell transfer | |||||||||
タイトル | ||||||||||
言語 | ja | |||||||||
タイトル | 抗PD-1抗体治療はリンパ球除去とT細胞移入という養子免疫療法による抗腫瘍効果を高増強する | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Lymphodepletion | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | PD-1 | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | T cell | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Immune checkpoint | |||||||||
資源タイプ | ||||||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||||||
タイプ | doctoral thesis | |||||||||
アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
著者 |
髙橋, 美帆
× 髙橋, 美帆
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抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Lymphodepleting cytotoxic regimens enhance the antitumor effects of adoptively transferred effector and naïve T cells. Although the mechanisms of antitumor immunity augmentation by lymphodepletion have been intensively investigated, the effects of lymphodepletion followed by T cell transfer on immune checkpoints in the tumor microenvironment remain unclear. The current study demonstrated that the expression of immune checkpoint molecules on transferred donor CD4+ and CD8+ T cells was significantly decreased in lymphodepleted tumor-bearing mice. In contrast, lymphodepletion did not reduce immune checkpoint molecule levels on recipient CD4+ and CD8+ T cells. Administration of anti-PD-1 antibodies after lymphodepletion and adoptive transfer of T cells significantly inhibited tumor progression. Further analysis revealed that transfer of both donor CD4+ and CD8+ T cells was responsible for the antitumor effects of a combination therapy consisting of lymphodepletion, T cell transfer and anti-PD-1 treatment. Our findings indicate that a possible mechanism underlying the antitumor effects of lymphodepletion followed by T cell transfer is the prevention of donor T cell exhaustion and dysfunction. PD-1 blockade may reinvigorate exhausted recipient T cells and augment the antitumor effects of lymphodepletion and adoptive T cell transfer. | |||||||||
言語 | en | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | Cancer Immunology, Immunotherapy. 2022, 71(6), 1357-1369. | |||||||||
言語 | en | |||||||||
DOI | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1007/s00262-021-03078-0 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021 | |||||||||
学位名 | ||||||||||
言語 | ja | |||||||||
学位名 | 博士(医学) | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関識別子 | 13101 | |||||||||
言語 | ja | |||||||||
学位授与機関名 | 新潟大学 | |||||||||
言語 | en | |||||||||
学位授与機関名 | Niigata University | |||||||||
学位授与年月日 | ||||||||||
学位授与年月日 | 2022-03-23 | |||||||||
学位授与番号 | ||||||||||
学位授与番号 | 甲第4981号 | |||||||||
学位記番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 新大院博(医)第1051号 | |||||||||
言語 | ja |