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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

インターフェロンγで刺激した間葉系幹細胞由来のエクソソームは肝線維化を効率的に改善する

http://hdl.handle.net/10191/0002000458
http://hdl.handle.net/10191/0002000458
1d555908-0fe8-438f-882d-986a5a50bd73
名前 / ファイル ライセンス アクション
r3nmk1016.pdf 本文 (2.85MB)
r3nmk1016_a.pdf 要旨 (438KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-10
タイトル
言語 en
タイトル Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cells effectively treat liver fibrosis
タイトル
言語 ja
タイトル インターフェロンγで刺激した間葉系幹細胞由来のエクソソームは肝線維化を効率的に改善する
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 竹内, 卓

× 竹内, 卓

en Takaeuchi, Suguru

ja 竹内, 卓

Search repository
抄録
内容記述タイプ Abstract
内容記述 Mesenchymal stromal cells (MSCs) are used for ameliorating liver fibrosis and aiding liver regeneration after cirrhosis; Here, we analyzed the therapeutic potential of small extracellular vesicles (sEVs) derived from interferon-γ (IFN-γ) pre-conditioned MSCs (γ-sEVs). γ-sEVs effectively induced anti-inflammatory macrophages with high motility and phagocytic abilities in vitro, while not preventing hepatic stellate cell (HSC; the major source of collagen fiber) activation in vitro. The proteome analysis of MSC-derived sEVs revealed anti-inflammatory macrophage inducible proteins (e.g., annexin-A1, lactotransferrin, and aminopeptidase N) upon IFN-γ stimulation. Furthermore, by enabling CX_3CR1+ macrophage accumulation in the damaged area, γ-sEVs ameliorated inflammation and fibrosis in the cirrhosis mouse model more effectively than sEVs. Single cell RNA-Seq analysis revealed diverse effects, such as induction of anti-inflammatory macrophages and regulatory T cells, in the cirrhotic liver after γ-sEV administration. Overall, IFN-γ pre-conditioning altered sEVs resulted in efficient tissue repair indicating a new therapeutic strategy.
言語 en
内容記述
内容記述タイプ Other
内容記述 NPJ Regenerative medicine. 2021, 6(1), 19.
言語 en
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41536-021-00132-4
権利
言語 en
権利情報 【○!C】 The Author(s) 2021
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
言語 ja
学位授与機関名 新潟大学
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-09-21
学位授与番号
学位授与番号 甲第4926号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第1016号
言語 ja
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