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Methods: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment. The prognostic value of body composition indexes at diagnosis and the changes in those indexes over 1 month was then evaluated. Results: In total, 45 patients (81.8%) received chemotherapy, chemoradiation, or radiation therapy, whereas the remaining patients underwent BSC. There were 27 patients (49.1%) who had low SMI at cancer diagnosis. Univariate analysis showed no significant associations between the baseline body composition indexes including SMI, VATI, SATI, and VSR and survival. 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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

切除不能進行膵癌症例において1か月間での急速な内臓脂肪の減少は予後不良と関連する

http://hdl.handle.net/10191/0002000457
d9b3b928-8e82-4d8d-825e-e8e8c086785f
名前 / ファイル ライセンス アクション
r3nmk1015.pdf 本文 (688KB)
r3nmk1015_a.pdf 要旨 (441KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-05-10
タイトル
言語 en
タイトル Rapid decline in visceral adipose tissue over 1 month is associated with poor prognosis in patients with unresectable pancreatic cancer
タイトル
言語 ja
タイトル 切除不能進行膵癌症例において1か月間での急速な内臓脂肪の減少は予後不良と関連する
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 pancreatic cancer
キーワード
言語 en
主題Scheme Other
主題 sarcopenia
キーワード
言語 en
主題Scheme Other
主題 subcutaneous adipose tissue
キーワード
言語 en
主題Scheme Other
主題 visceral adipose tissue
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 中野, 応央樹

× 中野, 応央樹

en Nakano, Oki

ja 中野, 応央樹

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background: Involuntary weight loss related to cachexia is common in patients with advanced cancer, but the association between body composition changes and survival is still unclear in pancreatic cancer. Methods: We retrospectively reviewed the clinical outcomes of 55 patients with advanced pancreatic cancer undergoing palliative therapy or best supportive care (BSC). The skeletal muscle index (SMI), visceral adipose tissue index (VATI), subcutaneous adipose tissue index (SATI), and visceral to subcutaneous adipose tissue area ratio (VSR) were calculated based on the cross-sectional area on two sets of computed tomography images obtained at cancer diagnosis and 1 month later before treatment. The prognostic value of body composition indexes at diagnosis and the changes in those indexes over 1 month was then evaluated. Results: In total, 45 patients (81.8%) received chemotherapy, chemoradiation, or radiation therapy, whereas the remaining patients underwent BSC. There were 27 patients (49.1%) who had low SMI at cancer diagnosis. Univariate analysis showed no significant associations between the baseline body composition indexes including SMI, VATI, SATI, and VSR and survival. Meanwhile, male sex (HR, 2.79; 95% CI, 1.16–6.71, p = 0.022) and higher decrease in VATI over 1 month (HR, 2.41; 95% CI, 1.13–5.13, p = 0.023) were identified as independent risk factors for mortality in multivariate analysis. Conclusion: Rapid decline in VAT over 1 month is closely associated with poorer survival in unresectable advanced pancreatic cancer. A short-term assessment of body composition changes may be a rational approach to predict prognosis in these patients.
言語 en
内容記述
内容記述タイプ Other
内容記述 Cancer medicine. 2021, 10(13), 4291-4301.
言語 en
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/cam4.3964
権利
言語 en
権利情報 【○!C】 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
学位授与機関名
言語 ja
学位授与機関名 新潟大学
学位授与機関名
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-09-21
学位授与番号
学位授与番号 甲第4925号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第1015号
言語 ja
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