WEKO3
AND
アイテム
{"_buckets": {"deposit": "6c5e7674-6877-4c32-ae61-22db82b2c7bb"}, "_deposit": {"id": "2000346", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000346"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000346", "sets": []}, "author_link": [], "item_6_date_granted_51": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u5e74\u6708\u65e5", "attribute_value_mlt": [{"subitem_dategranted": "2021-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u6a5f\u95a2", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "\u65b0\u6f5f\u5927\u5b66"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Niigata University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_48": {"attribute_name": "\u5b66\u4f4d\u540d", "attribute_value_mlt": [{"subitem_degreename": "\u535a\u58eb\uff08\u533b\u5b66\uff09", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Purpose To determine patients with abnormal sensation in the throat (AST) who would respond to potassium-competitive acid blocker (P-CAB) or serotonin noradrenaline reuptake inhibitor (SNRI) treatment. Methods AST patients were randomly divided into two groups. Thirty-one and 21 patients received P-CAB and SNRI treatment, respectively. GETS-J, the Japanese version of Glasgow Edinburgh Throat Scales (GETS), consisted of three subscales of throat symptoms (globus sensation, pain/swelling of the throat, and dysphagia) and somatic distress due to the disease, Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (FSSG), and Hospital Anxiety and Depression Scale (HADS) were used before and after treatments. Responders to treatments were defined as those who showed 50% or more decrease in symptom scores or somatic distress. Results Pre-treatment GETS-J pain/swelling scores and FSSG acid reflux scores were higher in P-CAB responders and decreased after treatment. Receiver operating characteristic curve for pain/swelling subscale had an area under the curve (AUC) of 0.792 to predict P-CAB responders and a score of 11 provided the best combination of sensitivity (62.5%) and specificity (80%). Somatic distress and HADS anxiety scores, but no other GETS-J symptom scores, decreased after SNRI treatment. Pre-treatment globus scores were lower in SNRI responders. AUC value for globus subscale to predict SNRI responders was 0.741 and a score of 6.5 provided the best combination of sensitivity (70%) and specificity (73%). Conclusions Pain/swelling is a characteristic symptom in AST patients who respond to P-CAB treatment. SNRI treatment would be effective for somatic distress in cases with mild symptoms.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "\u5185\u5bb9\u8a18\u8ff0", "attribute_value_mlt": [{"subitem_description": "European Archives of Oto-Rhino-Laryngology. 2021, 278(5), 1483-1489.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "\u5b66\u4f4d\u8a18\u756a\u53f7", "attribute_value_mlt": [{"subitem_description": "\u65b0\u5927\u535a(\u533b)\u7b2c1820\u53f7", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "\u5b66\u4f4d\u6388\u4e0e\u756a\u53f7", "attribute_value_mlt": [{"subitem_dissertationnumber": "\u4e59\u7b2c2254\u53f7"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1007/s00405-020-06544-0", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u3010\u25cb!C\u3011 The Author(s) 2021", "subitem_rights_language": "en"}, {"subitem_rights": "Creative Commons Attribution 4.0 International", "subitem_rights_language": "en", "subitem_rights_resource": "https://creativecommons.org/licenses/by/4.0/"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahashi, Nao", "creatorNameLang": "en"}, {"creatorName": "\u9ad8\u6a4b, \u5948\u592e", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"date": [{"dateType": "Available", "dateValue": "2022-04-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2nmo1820.pdf", "filesize": [{"value": "1.23MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "1.23MB", "url": {"label": "\u672c\u6587", "objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000346/files/r2nmo1820.pdf"}, "version_id": "01ee764e-c85f-4bc8-8c6f-c6ee22e71c56"}, {"date": [{"dateType": "Available", "dateValue": "2022-04-14"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2nmo1820_a.pdf", "filesize": [{"value": "257KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "257KB", "url": {"label": "\u8981\u65e8", "objectType": "abstract", "url": "https://niigata-u.repo.nii.ac.jp/record/2000346/files/r2nmo1820_a.pdf"}, "version_id": "367210db-fb8b-4a21-92c2-f7c4f834adc0"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "Gastro-esophageal reflux disease", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pharynx", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Sensation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "The Glasgow Edinburgh Throat Scale", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Prediction of effectiveness of potassium-competitive acid blocker and serotonin noradrenaline reuptake inhibitor on abnormal sensation in the throat : use of patient reported outcome measures (PROMs)", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "Prediction of effectiveness of potassium-competitive acid blocker and serotonin noradrenaline reuptake inhibitor on abnormal sensation in the throat : use of patient reported outcome measures (PROMs)", "subitem_title_language": "en"}, {"subitem_title": "\u5589\u982d\u7570\u5e38\u611f\u75c7\u306b\u5bfe\u3059\u308b\u30dc\u30ce\u30d7\u30e9\u30b6\u30f3\u30d5\u30de\u30eb\u9178\u5869\u3068SNRI\u306e\u52b9\u679c : GETS-J(\u65e5\u672c\u8a9e\u7248GETS)\u3092\u7528\u3044\u305f\u8a55\u4fa1", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["453/455", "471/561/562"], "permalink_uri": "http://hdl.handle.net/10191/0002000346", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-04-14"}, "publish_date": "2022-04-14", "publish_status": "0", "recid": "2000346", "relation": {}, "relation_version_is_last": true, "title": ["Prediction of effectiveness of potassium-competitive acid blocker and serotonin noradrenaline reuptake inhibitor on abnormal sensation in the throat : use of patient reported outcome measures (PROMs)"], "weko_shared_id": -1}
喉頭異常感症に対するボノプラザンフマル酸塩とSNRIの効果 : GETS-J(日本語版GETS)を用いた評価
http://hdl.handle.net/10191/0002000346
99b5408d-1b9e-4527-82a7-a2ca36abd746
名前 / ファイル | ライセンス | アクション | |
---|---|---|---|
![]() |
|
||
![]() |
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2022-04-14 | |||||||||
タイトル | ||||||||||
言語 | en | |||||||||
タイトル | Prediction of effectiveness of potassium-competitive acid blocker and serotonin noradrenaline reuptake inhibitor on abnormal sensation in the throat : use of patient reported outcome measures (PROMs) | |||||||||
タイトル | ||||||||||
言語 | ja | |||||||||
タイトル | 喉頭異常感症に対するボノプラザンフマル酸塩とSNRIの効果 : GETS-J(日本語版GETS)を用いた評価 | |||||||||
言語 | ||||||||||
言語 | eng | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Gastro-esophageal reflux disease | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Pharynx | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | Sensation | |||||||||
キーワード | ||||||||||
言語 | en | |||||||||
主題Scheme | Other | |||||||||
主題 | The Glasgow Edinburgh Throat Scale | |||||||||
資源タイプ | ||||||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||||||
タイプ | doctoral thesis | |||||||||
アクセス権 | ||||||||||
アクセス権 | open access | |||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
著者 |
高橋, 奈央
× 高橋, 奈央
|
|||||||||
抄録 | ||||||||||
内容記述タイプ | Abstract | |||||||||
内容記述 | Purpose To determine patients with abnormal sensation in the throat (AST) who would respond to potassium-competitive acid blocker (P-CAB) or serotonin noradrenaline reuptake inhibitor (SNRI) treatment. Methods AST patients were randomly divided into two groups. Thirty-one and 21 patients received P-CAB and SNRI treatment, respectively. GETS-J, the Japanese version of Glasgow Edinburgh Throat Scales (GETS), consisted of three subscales of throat symptoms (globus sensation, pain/swelling of the throat, and dysphagia) and somatic distress due to the disease, Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (FSSG), and Hospital Anxiety and Depression Scale (HADS) were used before and after treatments. Responders to treatments were defined as those who showed 50% or more decrease in symptom scores or somatic distress. Results Pre-treatment GETS-J pain/swelling scores and FSSG acid reflux scores were higher in P-CAB responders and decreased after treatment. Receiver operating characteristic curve for pain/swelling subscale had an area under the curve (AUC) of 0.792 to predict P-CAB responders and a score of 11 provided the best combination of sensitivity (62.5%) and specificity (80%). Somatic distress and HADS anxiety scores, but no other GETS-J symptom scores, decreased after SNRI treatment. Pre-treatment globus scores were lower in SNRI responders. AUC value for globus subscale to predict SNRI responders was 0.741 and a score of 6.5 provided the best combination of sensitivity (70%) and specificity (73%). Conclusions Pain/swelling is a characteristic symptom in AST patients who respond to P-CAB treatment. SNRI treatment would be effective for somatic distress in cases with mild symptoms. | |||||||||
言語 | en | |||||||||
内容記述 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | European Archives of Oto-Rhino-Laryngology. 2021, 278(5), 1483-1489. | |||||||||
言語 | en | |||||||||
DOI | ||||||||||
関連識別子 | ||||||||||
識別子タイプ | DOI | |||||||||
関連識別子 | https://doi.org/10.1007/s00405-020-06544-0 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報 | 【○!C】 The Author(s) 2021 | |||||||||
権利 | ||||||||||
言語 | en | |||||||||
権利情報Resource | https://creativecommons.org/licenses/by/4.0/ | |||||||||
権利情報 | Creative Commons Attribution 4.0 International | |||||||||
学位名 | ||||||||||
言語 | ja | |||||||||
学位名 | 博士(医学) | |||||||||
学位授与機関 | ||||||||||
学位授与機関識別子 | ||||||||||
学位授与機関識別子Scheme | kakenhi | |||||||||
学位授与機関識別子 | 13101 | |||||||||
学位授与機関名 | ||||||||||
言語 | ja | |||||||||
学位授与機関名 | 新潟大学 | |||||||||
学位授与機関名 | ||||||||||
言語 | en | |||||||||
学位授与機関名 | Niigata University | |||||||||
学位授与年月日 | ||||||||||
学位授与年月日 | 2021-03-23 | |||||||||
学位授与番号 | ||||||||||
学位授与番号 | 乙第2254号 | |||||||||
学位記番号 | ||||||||||
内容記述タイプ | Other | |||||||||
内容記述 | 新大博(医)第1820号 | |||||||||
言語 | ja |