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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

早期発症者と長期潜伏後発症者より分離した結核菌北京株のゲノム解析

http://hdl.handle.net/10191/0002000306
http://hdl.handle.net/10191/0002000306
8a6709a3-8632-4a94-bacc-63c1a3ee5fbe
名前 / ファイル ライセンス アクション
r2nmk1001.pdf 本文 (1.87MB)
r2nmk1001_a.pdf 要旨 (545KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-04-04
タイトル
言語 en
タイトル Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection
タイトル
言語 ja
タイトル 早期発症者と長期潜伏後発症者より分離した結核菌北京株のゲノム解析
言語
言語 eng
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 袴田, 真理子

× 袴田, 真理子

en Hakamata, Mariko

ja 袴田, 真理子

Search repository
抄録
内容記述タイプ Abstract
内容記述 Mycobacterium tuberculosis (Mtb) strains of Beijing lineage have caused great concern because of their rapid emergence of drug resistance and worldwide spread. DNA mutation rates that reflect evolutional adaptation to host responses and the appearance of drug resistance have not been elucidated in human-infected Beijing strains. We tracked and obtained an original Mtb isolate of Beijing lineage from the 1999 tuberculosis outbreak in Japan, as well as five other isolates that spread in humans, and two isolates from the patient caused recurrence. Three isolates were from patients who developed TB within one year after infection (rapid-progressor, RP), and the other three isolates were from those who developed TB more than one year after infection (slow-progressor, SP). We sequenced genomes of these isolates and analyzed the propensity and rate of genomic mutations. Generation time versus mutation rate curves were significantly higher for RP. The ratio of oxidative versus non-oxidation damages induced mutations was higher in SP than RP, suggesting that persistent Mtb are exposed to oxidative stress in the latent state. Our data thus demonstrates that higher mutation rates of Mtb Beijing strains during human infection is likely to account for the higher adaptability and an emergence ratio of drug resistance.
言語 en
内容記述
内容記述タイプ Other
内容記述 Scientific Reports. 2020, 10(1), 17997.
言語 en
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1038/s41598-020-75028-2
権利
言語 en
権利情報 【○!C】 The Author(s) 2020
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
言語 ja
学位授与機関名 新潟大学
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-03-23
学位授与番号
学位授与番号 甲第4847号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第1001号
言語 ja
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