{"_buckets": {"deposit": "2e137393-dcd5-4481-903c-aaff3eb79119"}, "_deposit": {"id": "2000306", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000306"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000306", "sets": ["455", "562"]}, "author_link": [], "control_number": "2000306", "item_6_date_granted_51": {"attribute_name": "学位授与年月日", "attribute_value_mlt": [{"subitem_dategranted": "2021-03-23"}]}, "item_6_degree_grantor_49": {"attribute_name": "学位授与機関", "attribute_value_mlt": [{"subitem_degreegrantor": [{"subitem_degreegrantor_language": "ja", "subitem_degreegrantor_name": "新潟大学"}, {"subitem_degreegrantor_language": "en", "subitem_degreegrantor_name": "Niigata University"}], "subitem_degreegrantor_identifier": [{"subitem_degreegrantor_identifier_name": "13101", "subitem_degreegrantor_identifier_scheme": "kakenhi"}]}]}, "item_6_degree_name_48": {"attribute_name": "学位名", "attribute_value_mlt": [{"subitem_degreename": "博士（医学）", "subitem_degreename_language": "ja"}]}, "item_6_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Mycobacterium tuberculosis (Mtb) strains of Beijing lineage have caused great concern because of their rapid emergence of drug resistance and worldwide spread. DNA mutation rates that reflect evolutional adaptation to host responses and the appearance of drug resistance have not been elucidated in human-infected Beijing strains. We tracked and obtained an original Mtb isolate of Beijing lineage from the 1999 tuberculosis outbreak in Japan, as well as five other isolates that spread in humans, and two isolates from the patient caused recurrence. Three isolates were from patients who developed TB within one year after infection (rapid-progressor, RP), and the other three isolates were from those who developed TB more than one year after infection (slow-progressor, SP). We sequenced genomes of these isolates and analyzed the propensity and rate of genomic mutations. Generation time versus mutation rate curves were significantly higher for RP. The ratio of oxidative versus non-oxidation damages induced mutations was higher in SP than RP, suggesting that persistent Mtb are exposed to oxidative stress in the latent state. Our data thus demonstrates that higher mutation rates of Mtb Beijing strains during human infection is likely to account for the higher adaptability and an emergence ratio of drug resistance.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_6_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Scientific Reports. 2020, 10(1), 17997.", "subitem_description_language": "en", "subitem_description_type": "Other"}]}, "item_6_description_53": {"attribute_name": "学位記番号", "attribute_value_mlt": [{"subitem_description": "新大院博(医)第1001号", "subitem_description_language": "ja", "subitem_description_type": "Other"}]}, "item_6_dissertation_number_52": {"attribute_name": "学位授与番号", "attribute_value_mlt": [{"subitem_dissertationnumber": "甲第4847号"}]}, "item_6_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1038/s41598-020-75028-2", "subitem_relation_type_select": "DOI"}}]}, "item_6_rights_15": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "【○!C】 The Author(s) 2020", "subitem_rights_language": "en"}, {"subitem_rights": "Creative Commons Attribution 4.0 International", "subitem_rights_language": "en", "subitem_rights_resource": "https://creativecommons.org/licenses/by/4.0/"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Hakamata, Mariko", "creatorNameLang": "en"}, {"creatorName": "袴田, 真理子", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"date": [{"dateType": "Available", "dateValue": "2022-04-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "r2nmk1001.pdf", "filesize": [{"value": "1.87MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "1.87MB", "url": {"label": "本文", "objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000306/files/r2nmk1001.pdf"}, "version_id": "b0f1c488-23cc-4399-b5fb-d24ab084231d"}, {"date": [{"dateType": "Available", "dateValue": "2022-04-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "r2nmk1001_a.pdf", "filesize": [{"value": "545KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": "545KB", "url": {"label": "要旨", "objectType": "abstract", "url": "https://niigata-u.repo.nii.ac.jp/record/2000306/files/r2nmk1001_a.pdf"}, "version_id": "65f108bd-928e-4959-9fe0-e9848d0a874a"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "doctoral thesis", "resourceuri": "http://purl.org/coar/resource_type/c_db06"}]}, "item_title": "Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection", "subitem_title_language": "en"}, {"subitem_title": "早期発症者と長期潜伏後発症者より分離した結核菌北京株のゲノム解析", "subitem_title_language": "ja"}]}, "item_type_id": "6", "owner": "1", "path": ["455", "562"], "permalink_uri": "http://hdl.handle.net/10191/0002000306", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2022-04-04"}, "publish_date": "2022-04-04", "publish_status": "0", "recid": "2000306", "relation": {}, "relation_version_is_last": true, "title": ["Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection"], "weko_shared_id": -1}