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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

日本人2型糖尿病維持透析患者におけるDPP-4阻害薬の血糖変動に与える影響 : 前向き観察研究

http://hdl.handle.net/10191/0002000290
d5d1dd26-663b-4a1d-80ce-8f77e93e1ee0
名前 / ファイル ライセンス アクション
r2nmk985.pdf 本文 (991KB)
r2nmk985_a.pdf 要旨 (545KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-04-04
タイトル
言語 en
タイトル Effects of DPP-4 Inhibitors on Blood Glucose Variability in Japanese Patients with Type 2 Diabetes on Maintenance Hemodialysis : A Prospective Observational Exploratory Study
タイトル
言語 ja
タイトル 日本人2型糖尿病維持透析患者におけるDPP-4阻害薬の血糖変動に与える影響 : 前向き観察研究
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 Blood glucose variability
キーワード
言語 en
主題Scheme Other
主題 Continuous glucose monitoring
キーワード
言語 en
主題Scheme Other
主題 DPP-4 inhibitors
キーワード
言語 en
主題Scheme Other
主題 Hemodialysis
キーワード
言語 en
主題Scheme Other
主題 Hypoglycemia
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 田中, 友美

× 田中, 友美

en Ishikawa-Tanaka, Tomomi

ja 田中, 友美

Search repository
抄録
内容記述タイプ Abstract
内容記述 Introduction: The precise blood glucose (BG) profile of hemodialysis patients is unclear, as is the effectiveness of dipeptidyl peptidase-4 (DPP-4) inhibitors in hemodialysis patients with type 2 diabetes. Here, we used continuous glucose monitoring (CGM) to evaluate BG variability in these patients and to assess the efficacy of DPP-4 inhibitors, particularly during hemodialysis sessions and at nighttime (UMIN000012638). Methods: We examined BG profiles using CGM in 31 maintenance hemodialysis patients with type 2 diabetes. Differences between patients with and without DPP-4 inhibitors (n = 15 and 16, respectively) were analyzed using a linear mixed-effects model to assess changes in glucose levels in 5-min intervals. Results: The model revealed that DPP-4 inhibitor use was significantly associated with suppression of a rapid drop in glucose levels, both with and without adjustment for BG levels at the start of hemodialysis. Moreover, the model revealed that the two groups differed significantly in the pattern of changes in BG levels from 0:00 to 6:55 am. DPP-4 inhibitors suppressed the tendency for subsequent nocturnal hypoglycemia. Conclusions: This prospective observational exploratory study showed that DPP-4 inhibitors could suppress BG variability during hemodialysis sessions as well as subsequent nocturnal changes in patients with type 2 diabetes.
言語 en
内容記述
内容記述タイプ Other
内容記述 Diabetes Therapy. 2020, 11(12), 2845–2861.
言語 en
DOI
関連識別子
識別子タイプ DOI
関連識別子 https://doi.org/10.1007/s13300-020-00928-5
権利
言語 en
権利情報 【○!C】 The Author(s) 2020
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc/4.0/
権利情報 Creative Commons Attribution-NonCommercial 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
学位授与機関名
言語 ja
学位授与機関名 新潟大学
学位授与機関名
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-03-23
学位授与番号
学位授与番号 甲第4831号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第985号
言語 ja
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