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Methods: Chronic hepatitis B (HBV) and C (HCV), NASH, and alcoholic steatohepatitis (ASH) patients who were assayed for Mac-2-binding protein glycosylation isomer (M2BPGi) (n = 272) and underwent magnetic resonance elastography (MRE) (n = 119) were enrolled. Patients who underwent MRE were also tested by ultrasound elastography (USE) (n = 80) and for M2BPGi (n = 97), autotaxin (ATX) (n = 62), and platelet count (n = 119), and their fibrosis-4 (FIB-4) index was calculated (n = 119). Results: FIB-4 index \u003e2, excluding HBV-infected patients, M2BPGi \u003e0.5, ATX \u003e0.5, and platelet count \u003c20×10^4/μL were the benchmark indices, and we took into consideration other risk factors, such as diabetes mellitus and age, to recommend further examinations, such as USE, based on the local situation to avoid overlooking hepatocellular carcinoma (HCC) in the clinic. 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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

1次医療機関や専門医療機関での、病因に基づいた慢性肝疾患のスクリーニングとフォローアップ

http://hdl.handle.net/10191/0002000283
http://hdl.handle.net/10191/0002000283
36f28c97-90bd-4a62-871d-7a78873f03a3
名前 / ファイル ライセンス アクション
r2nmk978.pdf 本文 (2.32MB)
r2nmk978_a.pdf 要旨 (547KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-04-04
タイトル
言語 en
タイトル Screening and follow-up of chronic liver diseases with understanding their etiology in clinics and hospitals
タイトル
言語 ja
タイトル 1次医療機関や専門医療機関での、病因に基づいた慢性肝疾患のスクリーニングとフォローアップ
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 autotaxin
キーワード
言語 en
主題Scheme Other
主題 fibrosis-4 index
キーワード
言語 en
主題Scheme Other
主題 hepatocellular carcinoma
キーワード
言語 en
主題Scheme Other
主題 Mac-2-binding protein glycosylation isomer
キーワード
言語 en
主題Scheme Other
主題 magnetic resonance elastography
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 小川, 雅裕

× 小川, 雅裕

en Ogawa, Masahiro

ja 小川, 雅裕

Search repository
抄録
内容記述タイプ Abstract
内容記述 Background and Aim: Considering the increasing prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH), the development of an effective screening and follow-up system that enables the recognition of etiological changes by primary physicians in clinics and specialists in hospitals is required. Methods: Chronic hepatitis B (HBV) and C (HCV), NASH, and alcoholic steatohepatitis (ASH) patients who were assayed for Mac-2-binding protein glycosylation isomer (M2BPGi) (n = 272) and underwent magnetic resonance elastography (MRE) (n = 119) were enrolled. Patients who underwent MRE were also tested by ultrasound elastography (USE) (n = 80) and for M2BPGi (n = 97), autotaxin (ATX) (n = 62), and platelet count (n = 119), and their fibrosis-4 (FIB-4) index was calculated (n = 119). Results: FIB-4 index >2, excluding HBV-infected patients, M2BPGi >0.5, ATX >0.5, and platelet count <20×10^4/μL were the benchmark indices, and we took into consideration other risk factors, such as diabetes mellitus and age, to recommend further examinations, such as USE, based on the local situation to avoid overlooking hepatocellular carcinoma (HCC) in the clinic. During specialty care in the hospital, MRE exhibited high diagnostic ability for fibrosis stages >F3 or F4; it could efficiently predict collateral circulation with high sensitivity, which can replace USE. We also identified etiological features and found that collateral circulation in NASH/ASH patients tended to exceed high-risk levels; moreover, these patients exhibited more variation in HCC-associated liver stiffness than the HBV and HCV patients. Conclusions: Using appropriate markers and tools, we can establish a stepwise, practical, noninvasive, and etiology-based screening and follow-up system in primary and specialty care.
言語 en
内容記述
内容記述タイプ Other
内容記述 JGH Open. 2020, 4(5), 827-837.
言語 en
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/jgh3.12406
権利
言語 en
権利情報 【○!C】 2020 The Authors. JGH Open published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by/4.0/
権利情報 Creative Commons Attribution 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
言語 ja
学位授与機関名 新潟大学
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-03-23
学位授与番号
学位授与番号 甲第4824号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第978号
言語 ja
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