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  1. 0 資料タイプ別
  2. 02 学位論文
  1. 250 大学院医歯学総合研究科(医)
  2. 60 博士学位論文
  3. 10 博士学位論文

Weaver 変異型マウスにおける methamphetamine 報酬効果の消失

http://hdl.handle.net/10191/0002000280
http://hdl.handle.net/10191/0002000280
bb832d7c-bbd4-4f52-b405-8fd2be4e9357
名前 / ファイル ライセンス アクション
r2nmk975.pdf 本文 (690KB)
r2nmk975_a.pdf 要旨 (546KB)
Item type 学位論文 / Thesis or Dissertation(1)
公開日 2022-04-04
タイトル
言語 en
タイトル Absence of methamphetamine-induced conditioned place preference in weaver mutant mice
タイトル
言語 ja
タイトル Weaver 変異型マウスにおける methamphetamine 報酬効果の消失
言語
言語 eng
キーワード
言語 en
主題Scheme Other
主題 CPP
キーワード
言語 en
主題Scheme Other
主題 GIRK
キーワード
言語 en
主題Scheme Other
主題 methamphetamine
キーワード
言語 en
主題Scheme Other
主題 reward
キーワード
言語 en
主題Scheme Other
主題 weaver mutant mice
資源タイプ
資源 http://purl.org/coar/resource_type/c_db06
タイプ doctoral thesis
アクセス権
アクセス権 open access
アクセス権URI http://purl.org/coar/access_right/c_abf2
著者 池窪, 結子

× 池窪, 結子

en Ikekubo, Yuiko

ja 池窪, 結子

Search repository
抄録
内容記述タイプ Abstract
内容記述 Aims: G protein-activated inwardly rectifying potassium (GIRK) channels are related to rewarding effects of addictive drugs. The GIRK2 subunit is thought to play key roles in the reward system. Weaver mutant mice exhibit abnormal GIRK2 function and different behaviors that are caused by several addictive substances compared with wild-type mice. However, mechanisms of reward-related alterations in weaver mutant mice remain unclear. The present study investigated changes in the rewarding effects of methamphetamine (METH) in weaver mutant mice. Methods: The rewarding effects of METH (4.0mg/kg) were investigated using the conditioned place preference (CPP) paradigm. Extracellular dopamine level in the nucleus accumbens (NAc) was measured by in vivo microdialysis. To identify brain regions that were associated with these changes in rewarding effects, METH-induced alterations of Fos expression were investigated by immunohistochemical analysis. Results: Weaver mutant mice exhibited a significant decrease in METH-induced CPP and dopamine release in the NAc. Methamphetamine significantly increased Fos expression in the posterior NAc (pNAc) shell in wild-type but not in weaver mutant mice. Conclusions: Methamphetamine did not induce rewarding effects in weaver mutant mice. The pNAc shell exhibited a significant difference in neuronal activity between wild-type and weaver mutant mice. The present results suggest that the absence of METH-induced CPP in weaver mutant mice is probably related to an innate reduction of dopamine and decreased neural activity in the pNAc shell that is partially attributable to the change of GIRK channel function. GIRK channels, especially those containing the GIRK2 subunit, appear to be involved in METH dependence.
言語 en
内容記述
内容記述タイプ Other
内容記述 Neuropsychopharmacology Reports. 2020, 40(4), 324-331.
言語 en
DOI
識別子タイプ DOI
関連識別子 https://doi.org/10.1002/npr2.12130
権利
言語 en
権利情報 【○!C】 2020 The Authors. Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsycho Pharmacology
権利
言語 en
権利情報Resource https://creativecommons.org/licenses/by-nc-nd/4.0/
権利情報 Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
学位名
言語 ja
学位名 博士(医学)
学位授与機関
学位授与機関識別子Scheme kakenhi
学位授与機関識別子 13101
言語 ja
学位授与機関名 新潟大学
言語 en
学位授与機関名 Niigata University
学位授与年月日
学位授与年月日 2021-03-23
学位授与番号
学位授与番号 甲第4821号
学位記番号
内容記述タイプ Other
内容記述 新大院博(医)第975号
言語 ja
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