{"_buckets": {"deposit": "9f24b40d-8cdd-44dd-96bb-a96c192cfeca"}, "_deposit": {"id": "2000028", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "2000028"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:02000028", "sets": []}, "author_link": [], "item_1627361970403": {"attribute_name": "\u51fa\u7248\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-02", "bibliographicIssueDateType": "Issued"}, "bibliographicPageEnd": "11", "bibliographicPageStart": "1", "bibliographicVolumeNumber": "73", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8\u7814\u7a76\u5831\u544a", "bibliographic_titleLang": "ja"}, {"bibliographic_title": "Bulletin of the Faculty of Agriculture", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "A bacterium species, Chromobacterium violaceum produces deep violet pigments, violacein 1 and deoxyviolacein 2, as tryptophan metabolites. A blocked mutant, B-4, which is prepared with N-methyl-N\u0027-nitrosoguanidine (NTG) mutagenic agent, generated two bisindole metabolites, indirubin 16 and (Z)-indol-3-ylmethylene-2-oxoindole 17, which are known to exhibit pharmacological activities. These structures were proposed based mainly on the detailed analyses of 2D NMR data in addition to the analyses of electronic and IR spectra. This is the first report to describe the production of 16 and 17 by C. violaceum. In addition, we propose the plausible biosynthetic pathway for 16 and 17 from tryptophan molecule.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}, {"subitem_description": "\u7d30\u83ccChromobacterium 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HMBC)\u3092\u7528\u3044\u3066\u305d\u308c\u3089\u306e\u69cb\u9020\u3092\u89e3\u660e\u3057\u305f\u3002\u30a4\u30f3\u30c7\u30eb\u30d3\u30f316\u53ca\u3073(Z)-indol-3-ylmethylene-2-oxoindole 17\u3068\u5224\u660e\u3057\u305f\u3002C.violaceum\u306b\u3088\u308b\u4e21\u8005\u306e\u4ee3\u8b1d\u7269\u306e\u751f\u7523\u306e\u5831\u544a\u4f8b\u306f\u306a\u304f\u306f\u3058\u3081\u3066\u306e\u4f8b\u3067\u3042\u308b\u3002\u751f\u5408\u6210\u7d4c\u8def\u3092\u63a8\u5b9a\u3057\u305f\u3002\u307e\u305f\u3001\u30d3\u30aa\u30e9\u30bb\u30a4\u30f3\u306f5\u3064\u306eORF VioA, B, C, D, E\u53ca\u3073\u975e\u9175\u7d20\u7684\u306a\u9178\u7d20\u6dfb\u52a0\u904e\u7a0b\u306e\u95a2\u4e0e\u304b\u3089\u6210\u308a\u7acb\u3063\u3066\u3044\u308b\u304c\u3001indol-3-ylmethylene-2-oxoindole 17\u306e\u751f\u6210\u306f\u3001vioA, B, D, E\u907a\u4f1d\u5b50\u304c\u7834\u58ca\u3055\u308c\u305f\u304c\u3001\u30d5\u30e9\u30d3\u30f3\u88dc\u9175\u7d20\u3092\u3082\u3064vioC\u907a\u4f1d\u5b50\u304c\u9178\u7d20\u6dfb\u52a0\u9175\u7d20\u3068\u3057\u3066\u306e\u6a5f\u80fd\u3092\u6709\u3057\u3066\u3044\u305f\u7d50\u679c\u3068\u3057\u3066\u751f\u7523\u3055\u308c\u305f\u3068\u63a8\u5b9a\u3057\u305f\u3002", "subitem_description_language": "ja", "subitem_description_type": "Abstract"}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u5927\u5b66\u8fb2\u5b66\u90e8", "subitem_publisher_language": "ja"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00183393", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0385-8634", "subitem_source_identifier_type": "PISSN"}]}, 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{"creatorName": "\u4f50\u3005\u6728, \u52c7\u8f14", "creatorNameLang": "ja"}]}, {"creatorNames": [{"creatorName": "Hoshino, Tsutomu", "creatorNameLang": "en"}, {"creatorName": "\u661f\u91ce, \u529b", "creatorNameLang": "ja"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-10-15"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "73_1-11.pdf", "filesize": [{"value": "1.31MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": "1.31MB", "url": {"objectType": "fulltext", "url": "https://niigata-u.repo.nii.ac.jp/record/2000028/files/73_1-11.pdf"}, "version_id": "708717f7-fe65-4d2c-8155-7e97deb2a6da"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "violacein", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "bisindole", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "indirubin", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "(Z)-indol-3-ylmethylene-2-oxoindole", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chromobacterium violaceum", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d3\u30aa\u30e9\u30bb\u30a4\u30f3", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30d3\u30b9\u30a4\u30f3\u30c9\u30fc\u30eb", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30a4\u30f3\u30c7\u30eb\u30d3\u30f3", "subitem_subject_language": "ja", "subitem_subject_scheme": "Other"}]}, "item_language": 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violaceum\u306e\u30d6\u30ed\u30c3\u30af\u5909\u7570\u682aB-4\u3067\u751f\u7523\u3055\u308c\u308b\u30d3\u30b9\u30a4\u30f3\u30c9\u30fc\u30eb\u7cfb\u5316\u5408\u7269\u30a4\u30f3\u30c7\u30eb\u30d3\u30f3\u3068indol-3-ylmethylene-2-oxoindole\u3001\u304a\u3088\u3073\u3053\u308c\u3089\u306e\u63a8\u5b9a\u751f\u5408\u6210\u7d4c\u8def", "subitem_title_language": "ja"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "485/872/1583/1634266335548"], "permalink_uri": "http://hdl.handle.net/10191/0002000028", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-10-15"}, "publish_date": "2021-10-15", "publish_status": "0", "recid": "2000028", "relation": {}, "relation_version_is_last": true, "title": ["Two bisindoles, indirubin and indol-3-ylmethylene-2-oxoindole, produced by the blocked mutant B-4 of Chromobacterium violaceum and implications for their biosynthetic pathways"], "weko_shared_id": -1}