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Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats
http://hdl.handle.net/10191/30621
http://hdl.handle.net/10191/306217721051e-2b82-4b7a-9ffb-01dbee7068ae
名前 / ファイル | ライセンス | アクション |
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10_7_813-817.pdf (514.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-01 | |||||
タイトル | ||||||
タイトル | Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pancreas | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pre-diabetes | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SDT rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | STZ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | insulin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diabetes | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ohta, Takeshi
× Ohta, Takeshi× Miyajima, Katsuhiro× Yamada, Takahisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The Spontaneously Diabetic Torii (SDT) rat is a new model of non-obese type 2 diabetes. In the present study, researchers investigated pathophysiological changes of male SDT rats in pre-diabetic stage from 8-16 weeks of age. In oral glucose tolerance test at 12 weeks of age, SDT rats showed glucose intolerance and decrease of glucose-stimulated insulin secretion. Different doses of Streptozotocin (STZ) were administered to SDT rats or SD rats and the pancreatic weakness was examined. SDT rats treated with STZ at a dose level of 20 mg kg-1 were diabetic within 1 week after treatment whereas SD rats got the diabetes after 30 mg kg-1 STZ was received. Insulin tolerance test was performed at 8, 16 and 24 weeks of age in order to examine the insulin sensitivity and the K value was calculated. Interestingly in SDT rats at 16 weeks of age, insulin sensitivity was increased as compared with that in SD rats. Pathohistological changes in pancreas such as atrophy of islets, multiple irregular projection of islets and islet fibrosis were observed in SDT rats at 15 weeks of age. In this study, SDT rat is a useful model for the analysis of the progression of pre-diabetes and the onset of type 2 diabetes. | |||||
書誌情報 |
Journal of animal and veterinary advances en : Journal of animal and veterinary advances 巻 10, 号 7, p. 813-817, 発行日 2011-09 |
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出版者 | ||||||
出版者 | Medwell Journals | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 16805593 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | info:doi/10.3923/javaa.2011.813.817 | |||||
権利 | ||||||
権利情報 | Copyright(C)2011 Medwell Journals | |||||
著者版フラグ | ||||||
値 | publisher | |||||
異版である | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | URI | |||||
関連識別子 | http://docsdrive.com/pdfs/medwelljournals/javaa/2011/813-817.pdf |