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  1. 0 資料タイプ別
  2. 01 学術雑誌論文
  1. 070 農学部
  2. 10 学術雑誌論文
  3. 10 査読済論文

Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats

http://hdl.handle.net/10191/30621
http://hdl.handle.net/10191/30621
7721051e-2b82-4b7a-9ffb-01dbee7068ae
名前 / ファイル ライセンス アクション
10_7_813-817.pdf 10_7_813-817.pdf (514.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2014-12-01
タイトル
タイトル Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats
タイトル
言語 en
タイトル Pathophysiological Changes in Pre-Diabetic Stage of Spontaneously Diabetic Torii (SDT) Rats
言語
言語 eng
キーワード
主題Scheme Other
主題 Pancreas
キーワード
主題Scheme Other
主題 pre-diabetes
キーワード
主題Scheme Other
主題 SDT rat
キーワード
主題Scheme Other
主題 STZ
キーワード
主題Scheme Other
主題 insulin
キーワード
主題Scheme Other
主題 diabetes
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ journal article
著者 Ohta, Takeshi

× Ohta, Takeshi

WEKO 6514

Ohta, Takeshi

Search repository
Miyajima, Katsuhiro

× Miyajima, Katsuhiro

WEKO 6515

Miyajima, Katsuhiro

Search repository
Yamada, Takahisa

× Yamada, Takahisa

WEKO 6516

Yamada, Takahisa

Search repository
抄録
内容記述タイプ Abstract
内容記述 The Spontaneously Diabetic Torii (SDT) rat is a new model of non-obese type 2 diabetes. In the present study, researchers investigated pathophysiological changes of male SDT rats in pre-diabetic stage from 8-16 weeks of age. In oral glucose tolerance test at 12 weeks of age, SDT rats showed glucose intolerance and decrease of glucose-stimulated insulin secretion. Different doses of Streptozotocin (STZ) were administered to SDT rats or SD rats and the pancreatic weakness was examined. SDT rats treated with STZ at a dose level of 20 mg kg-1 were diabetic within 1 week after treatment whereas SD rats got the diabetes after 30 mg kg-1 STZ was received. Insulin tolerance test was performed at 8, 16 and 24 weeks of age in order to examine the insulin sensitivity and the K value was calculated. Interestingly in SDT rats at 16 weeks of age, insulin sensitivity was increased as compared with that in SD rats. Pathohistological changes in pancreas such as atrophy of islets, multiple irregular projection of islets and islet fibrosis were observed in SDT rats at 15 weeks of age. In this study, SDT rat is a useful model for the analysis of the progression of pre-diabetes and the onset of type 2 diabetes.
書誌情報 Journal of animal and veterinary advances
en : Journal of animal and veterinary advances

巻 10, 号 7, p. 813-817, 発行日 2011-09
出版者
出版者 Medwell Journals
ISSN
収録物識別子タイプ ISSN
収録物識別子 16805593
DOI
識別子タイプ DOI
関連識別子 info:doi/10.3923/javaa.2011.813.817
権利
権利情報 Copyright(C)2011 Medwell Journals
著者版フラグ
値 publisher
異版である
関連タイプ isVersionOf
識別子タイプ URI
関連識別子 http://docsdrive.com/pdfs/medwelljournals/javaa/2011/813-817.pdf
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