{"_buckets": {"deposit": "c1895eac-c407-4923-9df0-7d4a467a9378"}, "_deposit": {"id": "19946", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19946"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019946", "sets": ["456", "1159"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "（A） Study on the Prevention of Progression of Diabetic Complications （B） Study on a new Protein which Localized in the Human Pancreatic B-cells"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1993-08", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "8", "bibliographicPageEnd": "671", "bibliographicPageStart": "659", "bibliographicVolumeNumber": "107", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "（A）Study on the prevention of progression of diabetic nephropathy （1）Determination of normal levels of AER in timed overnight urine samples Urinary excretion rate of 6 kinds of plasma proteins were measured in timed overnight urine samples of controls and NIDDM to determine normal levels of AER. Abnormal urinary excretion rate of plasma proteins were found when AER was more than 10 μg/min. From the results, less than 10 μg/min of AER was considered to be normal in timed overnight urine samples. （2）A new low-protein diet therapy Although dietary protein restriction prevented the progression of diabetic nephropathy, that may cause hypoproteinemia or malnutrition. So, improvement of this therapy was necessary. To select protein, administration of which does not induce glomerular hyper filtration （GFR）, acute protein load of four kinds of proteins was carried out. GFR increased after ingestion of tuna fish whereas it does not increase after administration of egg white, cheese and tofu. The finding suggests that the latter three kinds of protein can be excluded from dietary protein restriction. （3）A new drug therapy Effect of sandostatin on proteinuria was examined in experimental animals. The remarkable decrease of proteinuria was found in the uninephrectomized-streptozotocin diabetic rats after administration of sandostatin. The finding suggests that growth hormone may play some roles on occurrence of proteinuria in diabetic nephropathy. Clinical trial was carried out on a patient with diabetic triopathy. Proteinuria decreased immediately after administration of sandostatin. （B）Study on a new protein which localized in the human insulin secretory granules of pancreatic B-cells. Salivary peptide P-C like immunoreactivity, originally isolated from human whole saliva has later been found in the human pancreatic B-cells, Subsequently, the following findings were accumulated. 1, This substance localized in the insulin secretory granules. 2, This substance was different from insulin, precursor of insulin, amylin, salivary peptide P-C and its precursor Protein C. 3, This substance was immature in the fetal pancreatic B-cells. 4, This substance decreased in approximately 40% of non-insulin dependent diabetic pancreas. 5, This substance was an unknown protein with M.W.11,500. Common antigenic site between salivary peptide P-C and the substance was C-terminal 7 amino acids residues of salivary peptide P-C.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "123625", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ito, Seiki"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "伊藤, 正毅"}], "nameIdentifiers": [{"nameIdentifier": "123624", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-16"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "107(8)_659-671.pdf", "filesize": [{"value": "3.0 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 3000000.0, "url": {"label": "107(8)_659-671.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19946/files/107(8)_659-671.pdf"}, "version_id": "05e37ecc-9f29-46a3-a1af-1def30ed2539"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Prevention Diabetic Complication AER", "subitem_subject_scheme": "Other"}, {"subitem_subject": "P-C like immunoreactivity Human pancreatic B-cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "臨床的研究", "subitem_subject_scheme": "Other"}, {"subitem_subject": "基礎的研究", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "（A）糖尿病の合併症の進展阻止に関する研究（臨床研究）①夜間尿のアルブミン排泄率の正常値②新しい低蛋白療法について③新しい薬物療法について : 動物実験より臨床へ （B）ヒトの膵B-細胞のインスリン分泌顆粒に局在する新しい蛋白に関する研究（基礎的研究）", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "（A）糖尿病の合併症の進展阻止に関する研究（臨床研究）①夜間尿のアルブミン排泄率の正常値②新しい低蛋白療法について③新しい薬物療法について : 動物実験より臨床へ （B）ヒトの膵B-細胞のインスリン分泌顆粒に局在する新しい蛋白に関する研究（基礎的研究）"}, {"subitem_title": "（A）糖尿病の合併症の進展阻止に関する研究（臨床研究）①夜間尿のアルブミン排泄率の正常値②新しい低蛋白療法について③新しい薬物療法について : 動物実験より臨床へ （B）ヒトの膵B-細胞のインスリン分泌顆粒に局在する新しい蛋白に関する研究（基礎的研究）", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1159"], "permalink_uri": "http://hdl.handle.net/10191/37587", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-04"}, "publish_date": "2016-02-04", "publish_status": "0", "recid": "19946", "relation": {}, "relation_version_is_last": true, "title": ["（A）糖尿病の合併症の進展阻止に関する研究（臨床研究）①夜間尿のアルブミン排泄率の正常値②新しい低蛋白療法について③新しい薬物療法について : 動物実験より臨床へ （B）ヒトの膵B-細胞のインスリン分泌顆粒に局在する新しい蛋白に関する研究（基礎的研究）"], "weko_shared_id": null}