{"_buckets": {"deposit": "842a2f7f-a8e1-4107-82bf-b08f3af32071"}, "_deposit": {"id": "19482", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19482"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019482", "sets": ["456", "1152"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Paraneoplastic Neurological Syndrome : Clinical Features and Cloning of the Antigens Detected by the Anti-neural Antibodies (Recent Progress in Autoimmune Diseases)"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-03", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "193", "bibliographicPageStart": "190", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Paraneoplastic neurological syndrome is the remote effects of cancer on the nervous system which is the least common of the nonmetastatic complication of cancer. Present evidence suggests that some patients with paraneoplastic syndromes harbor autoantibodies in the serum and CSF that reacts with neuronal elements as well as with tumors. Certain of the auto-antibodies are sufficiently specific so that their presence in a patient with or without a paraneoplastic syndrome strongly suggests the presence of an underlying cancer. There is at least some evidence from lambert-Eaton myasthenic syndrome (LEMS) that the auto-antibodies may play a role in producing the paraneoplastic syndrome by reacting with neural antigens and interfering with function of the neural structure. The presence of auto-antibodies may serve to retard the growth of the underlying tumor even while it may destroy portions of the nervous system. We demonstrate a major 58 kD protein antigen in an immunoblot of human cerebellum by serum from a patient with paraneoplastic cerebellar degeneration (PCD). To identify the details of the target antigens, we isolated a cDNA clone from a human cerebellar library by immunoscreening using patient\u0027s serum. Homology searches revealed a similarity with the zinc finger proteins which may be important to maintain neural cells especially those in the cerebellum.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "121142", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Inuzuka, Takashi"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "犬塚, 貴"}], "nameIdentifiers": [{"nameIdentifier": "121141", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(3)_190-193.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "108(3)_190-193.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19482/files/108(3)_190-193.pdf"}, "version_id": "52e3634c-c5ea-49f1-b4fd-8e56bd411e08"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Paraneoplastic neurological syndrome", "subitem_subject_scheme": "Other"}, {"subitem_subject": "anti-neuronal antibody", "subitem_subject_scheme": "Other"}, {"subitem_subject": "autoimmune", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cDNA cloning", "subitem_subject_scheme": "Other"}, {"subitem_subject": "zinc finger protein", "subitem_subject_scheme": "Other"}, {"subitem_subject": "傍腫瘍性神経症候群", "subitem_subject_scheme": "Other"}, {"subitem_subject": "抗神経抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "自己免疫", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cDNA クローニング", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Zn フィンガー蛋白", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "4) Paraneoplastic Neurological Syndrome : 臨床と抗神経抗体の認識抗原の検索(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "4) Paraneoplastic Neurological Syndrome : 臨床と抗神経抗体の認識抗原の検索(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)"}, {"subitem_title": "4) Paraneoplastic Neurological Syndrome : 臨床と抗神経抗体の認識抗原の検索(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1152"], "permalink_uri": "http://hdl.handle.net/10191/38106", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-08"}, "publish_date": "2016-02-08", "publish_status": "0", "recid": "19482", "relation": {}, "relation_version_is_last": true, "title": ["4) Paraneoplastic Neurological Syndrome : 臨床と抗神経抗体の認識抗原の検索(シンポジウム 自己免疫疾患の新しい病態, 第487回新潟医学会)"], "weko_shared_id": null}