{"_buckets": {"deposit": "abfe8623-504d-4fee-8a91-43995ca7f2fa"}, "_deposit": {"id": "19369", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19369"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019369", "sets": ["456", "1150"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Antibodies Against Intercellular Adhesion Molecule-1 and Lymphocyte Function-Associated Antigen-1 Prevent the Progression of Experimental Autoimmune Myocarditis"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "385", "bibliographicPageStart": "375", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Experimental autoimmune myocarditis is a serious inflammatory heart disease which is characterized by lesions of infiltrated mononuclear cells and CD4 positive T lymphocytes. We demonstrated that lymphocyte function-associated antigen-1 (LFA-1) positive cells infiltrated into the lesions of this myocarditis. To elcidate the roles of adhesion molecules in the pathogenesis of autoimmune myocarditis, intercellular adhesion molecule-1 (ICAM-1)/LFA-1 pathway was investigated using rat experimental autoimmune myocarditis. Myocarditis was induced in Lewis rats by immunization with cardiac myosin. The rats were divided into four groups： control group, anti-ICAM-1-treated group, anti-LFA-1-treated group and a combination (both antibodies-treated) group. Myocardial inflammation was depressed in each antibody treated group, especially the preventive effect was augmented in the combination group. An immunohistologic study of the rat heart in the control group revealed massive infiltrations of LFA-1 or ICAM-1 positive cells, and an enhanced expression of ICAM-1 on the endothelial cells. On the other hand, the heart in the combination therapy group showed little infiltration of ICAM-1 or LFA-1 positive cells, and ICAM-1 expression was not enhanced along the endothelial cells. These data suggest that the ICAM-1/LFA-1 pathway has a crucial role in the pathogenesis of this autoimmune myocarditis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "120565", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hosono, Hiroyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "細野, 浩之"}], "nameIdentifiers": [{"nameIdentifier": "120564", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(5)_375-385.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "108(5)_375-385.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19369/files/108(5)_375-385.pdf"}, "version_id": "bdf1a423-afad-4624-826f-2d8eff43901e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "intercellular adhesion molecule-1 (ICAM-1)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lymphocyte function-associated antigen-1(LFA-1)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "monoclonal antibody (-ies)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "myoearditis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "モノクローナル抗体", "subitem_subject_scheme": "Other"}, {"subitem_subject": "心筋炎", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "実験的自己免疫性心筋炎の発症と進展過程へのICAM-1/LFA-1系の関与", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "実験的自己免疫性心筋炎の発症と進展過程へのICAM-1/LFA-1系の関与"}, {"subitem_title": "実験的自己免疫性心筋炎の発症と進展過程へのICAM-1/LFA-1系の関与", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1150"], "permalink_uri": "http://hdl.handle.net/10191/38254", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-02-10"}, "publish_date": "2016-02-10", "publish_status": "0", "recid": "19369", "relation": {}, "relation_version_is_last": true, "title": ["実験的自己免疫性心筋炎の発症と進展過程へのICAM-1/LFA-1系の関与"], "weko_shared_id": null}