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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第108巻第5号

中枢の興奮性神経情報伝達に関する分子生物学的研究

http://hdl.handle.net/10191/38257
http://hdl.handle.net/10191/38257
7a76b9a4-f783-4d50-8492-b437aeb7cd0d
名前 / ファイル ライセンス アクション
108(5)_329-336.pdf 108(5)_329-336.pdf (1.7 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-02-10
タイトル
タイトル 中枢の興奮性神経情報伝達に関する分子生物学的研究
タイトル
言語 en
タイトル 中枢の興奮性神経情報伝達に関する分子生物学的研究
言語
言語 jpn
キーワード
主題Scheme Other
主題 glutamate receptor channel
キーワード
主題Scheme Other
主題 NMDA receptor channel
キーワード
主題Scheme Other
主題 molecular diversity
キーワード
主題Scheme Other
主題 Mg^<2+> block site
キーワード
主題Scheme Other
主題 グルタミン酸受容体チャネル
キーワード
主題Scheme Other
主題 NMDA 受容体チャネル
キーワード
主題Scheme Other
主題 分子的多様性
キーワード
主題Scheme Other
主題 Mg^<2+>閉塞阻害部位
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Molecular Biological Studies on the Excitatory Synaptic Transmission in the Central Nervous System
著者 三品, 昌美

× 三品, 昌美

WEKO 120516

三品, 昌美

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著者別名
識別子 120517
識別子Scheme WEKO
姓名 Mishina, Masayoshi
抄録
内容記述タイプ Abstract
内容記述 The NMDA receptor channel plays a key role in activity-dependent synaptic plasticity such as long-term potentiation, which is thought to underlie memory and learning, and in experience-dependent synaptic plasticity of the developing brain. Abnormal activation of the NMDA receptor channel may trigger the neuronal cell death observed in various brain disorders. We have identified more than a dozen subunits of the glutamate receptor channel by molecular cloning. These subunits have been classified into six subfamilies according to the amino acid sequence homology. The members of the α subfamily constitute the AMPA-selective glutamate receptor channel, whereas the β and γ subfamilies include the subunits of the kainate-selective glutamate receptor channel. Highly active NMDA receptor channels are formed only when the distantly related ε snd ζ subunits are expressed together. The members of the ε subfamily are distinct with each other in function, distribution and regulation. In contrast to the wide distribution of the ε1 and ζ1 subunit mRNAs in the brain, the ε2 subunit mRNA is expressed selectively in the forebrain, and the ε3 subunit mRNA is found predominantly in the cerebellum. Functional analyses of the ε/ζ heteromeric NMDA receptor channels expressed from cloned cDNAs provide evidence that the molecular diversity of the ε subfamily underlies the functional heterogeneity of the NMDA receptor channel. Furthermore, we have identified a Mg^<2+> block site of the NMDA receptor channel by site-directed mutagenesis.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 108, 号 5, p. 329-336, 発行日 1994-05
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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