WEKO3
アイテム
中枢の興奮性神経情報伝達に関する分子生物学的研究
http://hdl.handle.net/10191/38257
http://hdl.handle.net/10191/382577a76b9a4-f783-4d50-8492-b437aeb7cd0d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
108(5)_329-336.pdf (1.7 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-02-10 | |||||
| タイトル | ||||||
| タイトル | 中枢の興奮性神経情報伝達に関する分子生物学的研究 | |||||
| タイトル | ||||||
| タイトル | 中枢の興奮性神経情報伝達に関する分子生物学的研究 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glutamate receptor channel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA receptor channel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | molecular diversity | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mg^<2+> block site | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | グルタミン酸受容体チャネル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NMDA 受容体チャネル | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 分子的多様性 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Mg^<2+>閉塞阻害部位 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Molecular Biological Studies on the Excitatory Synaptic Transmission in the Central Nervous System | |||||
| 著者 |
三品, 昌美
× 三品, 昌美 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 120517 | |||||
| 姓名 | Mishina, Masayoshi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The NMDA receptor channel plays a key role in activity-dependent synaptic plasticity such as long-term potentiation, which is thought to underlie memory and learning, and in experience-dependent synaptic plasticity of the developing brain. Abnormal activation of the NMDA receptor channel may trigger the neuronal cell death observed in various brain disorders. We have identified more than a dozen subunits of the glutamate receptor channel by molecular cloning. These subunits have been classified into six subfamilies according to the amino acid sequence homology. The members of the α subfamily constitute the AMPA-selective glutamate receptor channel, whereas the β and γ subfamilies include the subunits of the kainate-selective glutamate receptor channel. Highly active NMDA receptor channels are formed only when the distantly related ε snd ζ subunits are expressed together. The members of the ε subfamily are distinct with each other in function, distribution and regulation. In contrast to the wide distribution of the ε1 and ζ1 subunit mRNAs in the brain, the ε2 subunit mRNA is expressed selectively in the forebrain, and the ε3 subunit mRNA is found predominantly in the cerebellum. Functional analyses of the ε/ζ heteromeric NMDA receptor channels expressed from cloned cDNAs provide evidence that the molecular diversity of the ε subfamily underlies the functional heterogeneity of the NMDA receptor channel. Furthermore, we have identified a Mg＾<2+> block site of the NMDA receptor channel by site-directed mutagenesis. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 5, p. 329-336, 発行日 1994-05 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
