{"_buckets": {"deposit": "95f2f13b-4a25-45df-9bc5-15dcc5115092"}, "_deposit": {"id": "19362", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "19362"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00019362"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Molecular Biological Studies on the Excitatory Synaptic Transmission in the Central Nervous System"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "336", "bibliographicPageStart": "329", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The NMDA receptor channel plays a key role in activity-dependent synaptic plasticity such as long-term potentiation, which is thought to underlie memory and learning, and in experience-dependent synaptic plasticity of the developing brain. Abnormal activation of the NMDA receptor channel may trigger the neuronal cell death observed in various brain disorders. We have identified more than a dozen subunits of the glutamate receptor channel by molecular cloning. These subunits have been classified into six subfamilies according to the amino acid sequence homology. The members of the \u03b1 subfamily constitute the AMPA-selective glutamate receptor channel, whereas the \u03b2 and \u03b3 subfamilies include the subunits of the kainate-selective glutamate receptor channel. Highly active NMDA receptor channels are formed only when the distantly related \u03b5 snd \u03b6 subunits are expressed together. The members of the \u03b5 subfamily are distinct with each other in function, distribution and regulation. In contrast to the wide distribution of the \u03b51 and \u03b61 subunit mRNAs in the brain, the \u03b52 subunit mRNA is expressed selectively in the forebrain, and the \u03b53 subunit mRNA is found predominantly in the cerebellum. Functional analyses of the \u03b5/\u03b6 heteromeric NMDA receptor channels expressed from cloned cDNAs provide evidence that the molecular diversity of the \u03b5 subfamily underlies the functional heterogeneity of the NMDA receptor channel. Furthermore, we have identified a Mg\uff3e\u003c2+\u003e block site of the NMDA receptor channel by site-directed mutagenesis.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "120517", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Mishina, Masayoshi"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e09\u54c1, \u660c\u7f8e"}], "nameIdentifiers": [{"nameIdentifier": "120516", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(5)_329-336.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "108(5)_329-336.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/19362/files/108(5)_329-336.pdf"}, "version_id": "bdcc6a92-7812-48f8-a391-7ad9af8256c5"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "glutamate receptor channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NMDA receptor channel", "subitem_subject_scheme": "Other"}, {"subitem_subject": "molecular diversity", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mg^\u003c2+\u003e block site", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b0\u30eb\u30bf\u30df\u30f3\u9178\u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30eb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "NMDA \u53d7\u5bb9\u4f53\u30c1\u30e3\u30cd\u30eb", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5206\u5b50\u7684\u591a\u69d8\u6027", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mg^\u003c2+\u003e\u9589\u585e\u963b\u5bb3\u90e8\u4f4d", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u4e2d\u67a2\u306e\u8208\u596e\u6027\u795e\u7d4c\u60c5\u5831\u4f1d\u9054\u306b\u95a2\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u4e2d\u67a2\u306e\u8208\u596e\u6027\u795e\u7d4c\u60c5\u5831\u4f1d\u9054\u306b\u95a2\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76"}, {"subitem_title": "\u4e2d\u67a2\u306e\u8208\u596e\u6027\u795e\u7d4c\u60c5\u5831\u4f1d\u9054\u306b\u95a2\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1150"], "permalink_uri": "http://hdl.handle.net/10191/38257", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-02-10"}, "publish_date": "2016-02-10", "publish_status": "0", "recid": "19362", "relation": {}, "relation_version_is_last": true, "title": ["\u4e2d\u67a2\u306e\u8208\u596e\u6027\u795e\u7d4c\u60c5\u5831\u4f1d\u9054\u306b\u95a2\u3059\u308b\u5206\u5b50\u751f\u7269\u5b66\u7684\u7814\u7a76"], "weko_shared_id": null}