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マイネルト基底核破壊ラットにおける大脳皮質アストロサイトの反応性に関する研究
http://hdl.handle.net/10191/38294
http://hdl.handle.net/10191/38294ec58cc62-6639-4c45-9515-315ba9b3d29c
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
108(6)_428-439.pdf (5.8 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-02-10 | |||||
| タイトル | ||||||
| タイトル | マイネルト基底核破壊ラットにおける大脳皮質アストロサイトの反応性に関する研究 | |||||
| タイトル | ||||||
| タイトル | マイネルト基底核破壊ラットにおける大脳皮質アストロサイトの反応性に関する研究 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reactive astrocyte | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | glial fibrillary acidic protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | β-amyroid precursor protein | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | nucleus basalis of Meynert | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ventral tegmental area | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 反応性アストロサイト | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | グリア線維性酸性蛋白 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アミロイド前駆体蛋白 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | マイネルト基底核 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 腹側被蓋野 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Remote Astrocytic Response of Prefrontal Cortex Caused by the Lesions in the Nucleus Basalis of Meynert | |||||
| 著者 |
姉崎, 利治
× 姉崎, 利治 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 120211 | |||||
| 姓名 | Anezaki, Toshiharu | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary acidic protein (GFAP). In some rats, vehicle was injected into the nbM and in others 6-hydroxydopamine (6-OHDA) was injected into the ventral tegmental area (VTA). Quantitative Western blot analysis revealed significantly greater immunoreactivity for GFAP in the prefrontal cortex of nbM-lesioned rats. Immunohistochemical examination revealed fibrous and hypertrophic GFAP-positive astrocytes even one day after surgery, and this reaction was stronger at three days after surgery. In contrast, GFAP-positive astrocytes were not observed in the brains of vehicle-injected or VTA-lesioned rats, even 21 days after surgery. The present results indicate that cortical astrocytes respond to cholinergic deafferentation. In addition, the expression of amyroid precursor protein (APP) in the reactive astrocytes were examined by immunohistochemical techniques with antibody against APP. The reaction of astrocytes was induced by the deposition of kainic acid (KA) on the dura or the infusion of ibotenic acid into the ipsilateral nbM. The expression of GFAP was observed in the cortical astrocytes induced by both treatment, but the expression of APP was observed only in the reactive astrocytes in the cortex injected with KA. This suggests that the reaction of astrocytes is heterogeneous dependent on the feature of the lesion. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 6, p. 428-439, 発行日 1994-06 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
