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It is well known that cells from XP patients have a defective DNA repair system. We studied neuropathologically two cases of XP with neurological abnormalities (De Sanctis-Cacchione syndrome). The pattern of topographical distribution and severity of neuron loss in the nervous system appeared to be similar to that seen in aged persons or patients with Alzheimer\u0027s disease. However, no senile plaques or neurofibrillary tangles were evident in the present cases. We consider that further studies of this human genetic disease are important for helping to clarify the mechanisms of neuronal cell death in normal cerebral aging as well as in Alzheimer\u0027s disease.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "119875", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Takahashi, Hitoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "119876", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kakita, Akiyoshi"}]}, {"nameIdentifiers": [{"nameIdentifier": "119877", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Ikuta, Fusahiro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": 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