{"_buckets": {"deposit": "6cb793dc-f479-42c3-af0a-7f8e763a74ad"}, "_deposit": {"id": "18940", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18940"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00018940"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "Abnormal Development of the Rat Brain Induced by ENU Treatment in the Stage of Gliogenesis"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1994-10", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "10", "bibliographicPageEnd": "735", "bibliographicPageStart": "724", "bibliographicVolumeNumber": "108", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "To clarify the effect of altered gliogenesis during the late stage of CNS development, suckling Wistar albino rats were injected intraperitoneally with ethylnitrosourea (ENU), an inhibitor of DNA synthesis, at 80 mg/kg body weight, once a day on postnatal day 2 (P2), P3 and P4. Eight hours after ENU injection, many pyknotic cells were observed in the subventricular zone. The P21 rat brains treated with ENU were small, and the cerebral white matter was thinner than normal. The oligodendrocytes were small in number and distributed randomly in the white matter without their usual bead-like arrangement. Myelination in the cerebral white matter in the ENU-treated rats was retarded, and a large number of small unmyelinated fibers was observed. Immunoreactivity for myelin basic protein was weak, and the usual linear staining of the myelin sheaths was obscure. GFAP immunostaining revealed a scarcity of immunopositive astrocytic cell bodies and processes. These findings suggest that the mitotic cell damage caused by ENU during the stage of gliogenesis produces the disturbance of axonal development as well as a reduction in the number of oligodendrocytes and astrocytes, resulting in the formation of a small brain.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "118218", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hayashi, Shintaro"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6797, \u68ee\u592a\u90ce"}], "nameIdentifiers": [{"nameIdentifier": "118217", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "108(10)_724-735.pdf", "filesize": [{"value": "7.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 7400000.0, "url": {"label": "108(10)_724-735.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/18940/files/108(10)_724-735.pdf"}, "version_id": "fcb2536a-7e00-4802-88a9-d01a7c0db881"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "gliogenesis", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ENU", "subitem_subject_scheme": "Other"}, {"subitem_subject": "malformation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "development", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cerebrum", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u30b0\u30ea\u30a2\u7d30\u80de\u7523\u751f", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5947\u5f62\u8133", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u767a\u9054", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5927\u8133", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u30b0\u30ea\u30a2\u7d30\u80de\u7523\u751f\u671f\u306e\u5206\u88c2\u671f\u7d30\u80de\u969c\u5bb3\u306b\u57fa\u3065\u304f\u30e9\u30c3\u30c8\u5927\u8133\u5f62\u6210\u7570\u5e38\u306e\u89b3\u5bdf", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u30b0\u30ea\u30a2\u7d30\u80de\u7523\u751f\u671f\u306e\u5206\u88c2\u671f\u7d30\u80de\u969c\u5bb3\u306b\u57fa\u3065\u304f\u30e9\u30c3\u30c8\u5927\u8133\u5f62\u6210\u7570\u5e38\u306e\u89b3\u5bdf"}, {"subitem_title": "\u30b0\u30ea\u30a2\u7d30\u80de\u7523\u751f\u671f\u306e\u5206\u88c2\u671f\u7d30\u80de\u969c\u5bb3\u306b\u57fa\u3065\u304f\u30e9\u30c3\u30c8\u5927\u8133\u5f62\u6210\u7570\u5e38\u306e\u89b3\u5bdf", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1145"], "permalink_uri": "http://hdl.handle.net/10191/40291", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2016-03-29"}, "publish_date": "2016-03-29", "publish_status": "0", "recid": "18940", "relation": {}, "relation_version_is_last": true, "title": ["\u30b0\u30ea\u30a2\u7d30\u80de\u7523\u751f\u671f\u306e\u5206\u88c2\u671f\u7d30\u80de\u969c\u5bb3\u306b\u57fa\u3065\u304f\u30e9\u30c3\u30c8\u5927\u8133\u5f62\u6210\u7570\u5e38\u306e\u89b3\u5bdf"], "weko_shared_id": null}