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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第108巻第10号

グリア細胞産生期の分裂期細胞障害に基づくラット大脳形成異常の観察

http://hdl.handle.net/10191/40291
http://hdl.handle.net/10191/40291
9c240ee7-bb52-4b1f-9851-f3389d9c5573
名前 / ファイル ライセンス アクション
108(10)_724-735.pdf 108(10)_724-735.pdf (7.4 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-03-29
タイトル
タイトル グリア細胞産生期の分裂期細胞障害に基づくラット大脳形成異常の観察
タイトル
言語 en
タイトル グリア細胞産生期の分裂期細胞障害に基づくラット大脳形成異常の観察
言語
言語 jpn
キーワード
主題Scheme Other
主題 gliogenesis
キーワード
主題Scheme Other
主題 ENU
キーワード
主題Scheme Other
主題 malformation
キーワード
主題Scheme Other
主題 development
キーワード
主題Scheme Other
主題 cerebrum
キーワード
主題Scheme Other
主題 グリア細胞産生
キーワード
主題Scheme Other
主題 奇形脳
キーワード
主題Scheme Other
主題 発達
キーワード
主題Scheme Other
主題 大脳
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Abnormal Development of the Rat Brain Induced by ENU Treatment in the Stage of Gliogenesis
著者 林, 森太郎

× 林, 森太郎

WEKO 118217

林, 森太郎

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著者別名
識別子 118218
識別子Scheme WEKO
姓名 Hayashi, Shintaro
抄録
内容記述タイプ Abstract
内容記述 To clarify the effect of altered gliogenesis during the late stage of CNS development, suckling Wistar albino rats were injected intraperitoneally with ethylnitrosourea (ENU), an inhibitor of DNA synthesis, at 80 mg/kg body weight, once a day on postnatal day 2 (P2), P3 and P4. Eight hours after ENU injection, many pyknotic cells were observed in the subventricular zone. The P21 rat brains treated with ENU were small, and the cerebral white matter was thinner than normal. The oligodendrocytes were small in number and distributed randomly in the white matter without their usual bead-like arrangement. Myelination in the cerebral white matter in the ENU-treated rats was retarded, and a large number of small unmyelinated fibers was observed. Immunoreactivity for myelin basic protein was weak, and the usual linear staining of the myelin sheaths was obscure. GFAP immunostaining revealed a scarcity of immunopositive astrocytic cell bodies and processes. These findings suggest that the mitotic cell damage caused by ENU during the stage of gliogenesis produces the disturbance of axonal development as well as a reduction in the number of oligodendrocytes and astrocytes, resulting in the formation of a small brain.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 108, 号 10, p. 724-735, 発行日 1994-10
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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