WEKO3
アイテム
1)遺伝疾患としての糖尿病 : 分子生物学的手法と最近の知見(シンポジウム 糖尿病研究の進歩と治療, 第498回新潟医学会)
http://hdl.handle.net/10191/40525
http://hdl.handle.net/10191/405258eb7a742-7856-470f-87bf-09ce97c80c57
名前 / ファイル | ライセンス | アクション |
---|---|---|
108(12)_873-878.pdf (1.0 MB)
|
|
Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2016-03-29 | |||||
タイトル | ||||||
タイトル | 1)遺伝疾患としての糖尿病 : 分子生物学的手法と最近の知見(シンポジウム 糖尿病研究の進歩と治療, 第498回新潟医学会) | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | 1)遺伝疾患としての糖尿病 : 分子生物学的手法と最近の知見(シンポジウム 糖尿病研究の進歩と治療, 第498回新潟医学会) | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | non-insulin-dependent diabetes mellitus (NIDDM) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular biology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | a disease susceptibilty gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reverse genetics (positional cloning) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Candidate gene approach | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | maturity-onset diabetes of the young (MODY) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glucokinase gene | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 非インスリン依存性糖尿病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 分子生物学 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 疾患感受性遺伝子 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 逆行性遺伝学 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 候補遺伝子アプローチ | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | MODY | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | グルコカイネース遺伝子 | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | Diabetes Mellitua as An Inheritable Disease : Recent Results Obtained by Molecular Genetics (Recent Advances in Research and Treatment of Diabetes Mellitus) | |||||
著者 |
山崎, 雅俊
× 山崎, 雅俊× 伊藤, 正毅× 柴田, 昭 |
|||||
著者別名 | ||||||
識別子 | 117667 | |||||
識別子Scheme | WEKO | |||||
姓名 | Yamazaki, Masatoshi | |||||
著者別名 | ||||||
識別子 | 117668 | |||||
識別子Scheme | WEKO | |||||
姓名 | Ito, Seiki | |||||
著者別名 | ||||||
識別子 | 117669 | |||||
識別子Scheme | WEKO | |||||
姓名 | Shibata, Akira | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Although non-insulin-dependent diabetes mellitus (NIDDM) has been widely thought to be an inheritable disease, the identification of a major gene in NIDDM has not been demonstrated by the classical genetics. One of reasons for the failure to find any clear trend was due to the fact that NDDM is a multifactorial disease, in which several major genes are involved in the onset and progression. This fact was partly demonstrated from monozygotic twin studies. However, we now can have a cue to identify the major genes of NIDDM by virtue of molecular biology (recombinant DNA technology). There are at least three major approach to identify a disease susceptibility gene ; classical approach, reverse genetics (positional cloning) and candidate gene approach. Mutations in insulin gene in patients with abnormal insulinemia were identified by classical approach, in which abnormal insulin was firstly isolated from patients' blood, and secondly, the gene coding the abnormal insulin was isolated by molecular cloning. Positional cloning is a method to identify a disease susceptibility gene based on the linkage analysis between various well-known genetic markers and the disease. By this method, it has been demonstrated that gene for maturity-onset diabetes of the young (MODY), a from of NIDDM with an autosomal dominant inheritance is linked to adenosine deaminase gene locus on chromosome 20q. Candidate gene approach is the method to examine whether the genes which are thought to be involved in the abnormal phenotype of a disease, is related to the disease or not. In 1992, close linkage of glucokinase gene locus on chromosome 7p to MODY of French families has been revealed, and furthermore, non-sense mutation in the glucokinase gene has been identified in one of the families. Although the tremedous progress in molecular biology is of benefit to us to obtain various genetic informations of NIDDM such as described above, the cases in which mutations in genes were identified until now in Japanese patients with NIDDM are quite rare. Therefore, we might have a time identifying all gene abnormalities in all patients with NIDDM. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 108, 号 12, p. 873-878, 発行日 1994-12 |
|||||
出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |