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3種類のShort Tandem Repeat多型の親子鑑定における有用性について
http://hdl.handle.net/10191/42255
http://hdl.handle.net/10191/42255c31759a6-f60f-4f27-b68f-bd4344c1c16c
名前 / ファイル | ライセンス | アクション |
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109(3)_122-135.pdf (2.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2016-06-23 | |||||
タイトル | ||||||
タイトル | 3種類のShort Tandem Repeat多型の親子鑑定における有用性について | |||||
タイトル | ||||||
タイトル | 3種類のShort Tandem Repeat多型の親子鑑定における有用性について | |||||
言語 | en | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Short tandem repeat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | GCG | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | vWF | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | TH | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Parentage testing | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Exclusion probability | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 親子鑑定 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 否定確率 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
その他のタイトル | ||||||
その他のタイトル | A Feasibility of Three Short Tandem Repeat Markers for Parentage Testing | |||||
著者 |
藤田, 一
× 藤田, 一 |
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著者別名 | ||||||
識別子Scheme | WEKO | |||||
識別子 | 116919 | |||||
姓名 | Fujita, Hajime | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A feasibility of three short tandem repeat (STR) markers, GCG, vWF and TH, for parentage testing was investigated with a Japanese population data that we have reported previously. Thirty-three subjects from eight families were genotyped for three STR loci using PCR amplification followed by denaturing polyacrylamide gel electrophoresis. Pedigree analysis of eight families on three STR loci confirmed Mendelian inheritance. Probabilities of parentage and paternity exclusion were calculated from the allele frequencies. Probabilities of parentage exclusion of 15 parent-child pairs were from 0.8761 to 0.2970 (GCG), from 0.8668 to 0.1544 (vWF) and from 0.6100 to 0.1030 (TH), respectively. The cumulatives were from 0.9746 to 0.6747. Exclusion probability of paternity was usually higher than that of parentage because mother's genotype was available for the calculation. Paternity tests among 15 cases of mother and child and unrelated 210 individuals were carried out. In one case, the paternity of 51 persons (24.3 %) was not excluded and their paternity probabilities of Essen Mueller's formula were from 0.9501 to 0.7043. Unexpectedly, the probabilities of 28 persons were higher (0.9501-0.8265) than that of true father (0.7043). In addition, cumulative exclusion probability from 3 STR markers was 0.921, which was nearly equal to that from 16 kinds of conventional blood group markers (0.972). In a case of disputed paternity, the paternity of alleged father was excluded only with vWF marker, but not two other STRs and seven blood group markers. This study revealed that DNA typing with 3 STR markers is very useful for paternity testing. | |||||
書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 109, 号 3, p. 122-135, 発行日 1995-03 |
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出版者 | ||||||
出版者 | 新潟医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00290440 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00182415 | |||||
著者版フラグ | ||||||
値 | publisher |