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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第109巻第3号

3種類のShort Tandem Repeat多型の親子鑑定における有用性について

http://hdl.handle.net/10191/42255
http://hdl.handle.net/10191/42255
c31759a6-f60f-4f27-b68f-bd4344c1c16c
名前 / ファイル ライセンス アクション
109(3)_122-135.pdf 109(3)_122-135.pdf (2.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-06-23
タイトル
タイトル 3種類のShort Tandem Repeat多型の親子鑑定における有用性について
タイトル
言語 en
タイトル 3種類のShort Tandem Repeat多型の親子鑑定における有用性について
言語
言語 jpn
キーワード
主題Scheme Other
主題 Short tandem repeat
キーワード
主題Scheme Other
主題 GCG
キーワード
主題Scheme Other
主題 vWF
キーワード
主題Scheme Other
主題 TH
キーワード
主題Scheme Other
主題 Parentage testing
キーワード
主題Scheme Other
主題 Exclusion probability
キーワード
主題Scheme Other
主題 親子鑑定
キーワード
主題Scheme Other
主題 否定確率
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル A Feasibility of Three Short Tandem Repeat Markers for Parentage Testing
著者 藤田, 一

× 藤田, 一

WEKO 116918

藤田, 一

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著者別名
識別子 116919
識別子Scheme WEKO
姓名 Fujita, Hajime
抄録
内容記述タイプ Abstract
内容記述 A feasibility of three short tandem repeat (STR) markers, GCG, vWF and TH, for parentage testing was investigated with a Japanese population data that we have reported previously. Thirty-three subjects from eight families were genotyped for three STR loci using PCR amplification followed by denaturing polyacrylamide gel electrophoresis. Pedigree analysis of eight families on three STR loci confirmed Mendelian inheritance. Probabilities of parentage and paternity exclusion were calculated from the allele frequencies. Probabilities of parentage exclusion of 15 parent-child pairs were from 0.8761 to 0.2970 (GCG), from 0.8668 to 0.1544 (vWF) and from 0.6100 to 0.1030 (TH), respectively. The cumulatives were from 0.9746 to 0.6747. Exclusion probability of paternity was usually higher than that of parentage because mother's genotype was available for the calculation. Paternity tests among 15 cases of mother and child and unrelated 210 individuals were carried out. In one case, the paternity of 51 persons (24.3 %) was not excluded and their paternity probabilities of Essen Mueller's formula were from 0.9501 to 0.7043. Unexpectedly, the probabilities of 28 persons were higher (0.9501-0.8265) than that of true father (0.7043). In addition, cumulative exclusion probability from 3 STR markers was 0.921, which was nearly equal to that from 16 kinds of conventional blood group markers (0.972). In a case of disputed paternity, the paternity of alleged father was excluded only with vWF marker, but not two other STRs and seven blood group markers. This study revealed that DNA typing with 3 STR markers is very useful for paternity testing.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 109, 号 3, p. 122-135, 発行日 1995-03
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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