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骨髄移植に伴うヒト骨髄の形態学的変化 : 電子顕微鏡による観察
http://hdl.handle.net/10191/42254
http://hdl.handle.net/10191/42254f68c51dd-4484-456a-bee1-a7c82df83566
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
109(3)_112-121.pdf (4.4 MB)
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| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2016-06-23 | |||||
| タイトル | ||||||
| タイトル | 骨髄移植に伴うヒト骨髄の形態学的変化 : 電子顕微鏡による観察 | |||||
| タイトル | ||||||
| タイトル | 骨髄移植に伴うヒト骨髄の形態学的変化 : 電子顕微鏡による観察 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | bone marrow transplantation | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ultrastructure | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | stromal cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | reticular cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | endothelial cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fat cell | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 骨髄移植 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 微細構造 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 骨髄支持細胞 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 細網細胞 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 洞内皮細胞 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 脂肪細胞 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Morphological Changes of the Human Bone Marrow before and after Bone Marrow Transplantation : An Electron Microscopic Study | |||||
| 著者 |
八木沢, 久美子
× 八木沢, 久美子 |
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| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 116917 | |||||
| 姓名 | Yagisawa, Kumiko | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Bone marrow transplantation (BMT) has been long carried out for many patients with hematological malignancy. However, few reports have been available concerning the ultrastructural changes of marrow stromal cells (non-hematopoietic cells) before and after BMT. In the present study, the bone marrow from six patients was examined under an electron microscope on the day of BMT and at following stages. The findings on the day of BMT were supplemented by observation of the bone marrow from irradiated rats. In the bone marrow after irradiation and administration of cytotoxic drugs, there were surviving stromal cells consisting of reticular cells, endothelial cells, macrophages and fat cells. This finding supports a generally accepted idea that the stromal cells are important for homing and proliferation of transplanted hematopoietic stem cells. However, network of reticular cells and vascular arrangement of endothelial cells were severely damaged by chemo-radio-therapy before BMT. It is doubtful that such stromal cells maintain the hematopoietic microenvironment for homing of transplanted cells. Enlargement of lipid droplets in fat cells was commonly found in humans and rats. Ultrastructure of the bone marrow at recovering stages after BMT differed among patients. In cases with hematologically sound recovery, the bone marrow revealed ultrastructure similar to that in normal marrow. In contrast, in cases with hematologically poor recovery, reconstruction of the stromal cells was incomplete even more than 28 days after BMT. This finding suggests that reconstruction of the stromal cells is intimately related to the hematological recovery of the bone marrow. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 109, 号 3, p. 112-121, 発行日 1995-03 |
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| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
