ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

{"_buckets": {"deposit": "79209f64-542c-4c06-8177-2c6be428efbf"}, "_deposit": {"id": "18242", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "18242"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00018242", "sets": ["456", "1132"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Direct Detection of Activated Platelets in the Patients with Prosthetic Heart Valve by Flow Cytometry and its Pathophysiological Significance"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1996-02", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "85", "bibliographicPageStart": "78", "bibliographicVolumeNumber": "110", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Thromboembolism is frequently observed in patients with prosthetic heart valve and is believed to be a major cause of post-operative morbidity and mortality. The aim of this study is to elucidate the role of activated platelets in the patients with prosthetic heart valve. Forty patients (23 female and 17 male) were operated on between 1967 and 1994 for prosthetic heart valve replacement in our university. Mean age was 55 years (range 2~68). All patients received anti-coagulant therapy. In 40 patients with prosthetic heart valve and 20 normal subjects, activated platelets were detected by flow-cytometric measurement of the proteins CD62P and CD63, which are expressed on the platelet surface membrane during platelet activation. Among healthy volunteers, a small percentage of platelets were activated (CD62P: 3.14±0.82%, CD63: 3.53±1.29%). In contrast, the patients group showed increased percentage of activated platelets. (CD62P: 4.08±2.25%, p=N.S., CD63: 4.82±2.70%, p\u003c0.05). In order to elucidate the pathophysiological role of the activated platelets in the patients, the 40 patients were divided into two groups according to the percentage of the activated platelets; activated platelets group (CD62P≧4.77% or CD63≧6.26%) and non-activated platelets group (CD62P\u003c4.77% and CD63\u003c6.26%). In the two groups, I analyzed the difference of four clinical factors, 1) history of prior cerebral infarction, 2) adequacy of anti-coagulant therapy (thrombotest\u003c15% or not), 3) heart rhythm (atrial fibrillation or sinus rhythm) and, 4) anti-platelet therapy. In the four clinical factors, the history of prior cerebral infarction was significantly higher in the activated group than the non-activated group. These results suggest that activated platelets actually circulate in the peripheral blood of the patients with prosthetic heart valve and are involved in the pathogenesis of thromboembolism such as cerebral infarction.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "114322", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Hori, Tomoyuki"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "堀, 知行"}], "nameIdentifiers": [{"nameIdentifier": "114321", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "110(2)_78-85.pdf", "filesize": [{"value": "1.8 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1800000.0, "url": {"label": "110(2)_78-85.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/18242/files/110(2)_78-85.pdf"}, "version_id": "3a94f423-e1e0-4a18-aff8-942113a6bfe4"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "activated platelets", "subitem_subject_scheme": "Other"}, {"subitem_subject": "flow cytometry", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD62P", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD63", "subitem_subject_scheme": "Other"}, {"subitem_subject": "prosthetic heart valve", "subitem_subject_scheme": "Other"}, {"subitem_subject": "history of prior cerebral infarction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "活性化血小板", "subitem_subject_scheme": "Other"}, {"subitem_subject": "フローサイトメトリー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "人工弁置換", "subitem_subject_scheme": "Other"}, {"subitem_subject": "脳梗塞の既往", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて"}, {"subitem_title": "心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1132"], "permalink_uri": "http://hdl.handle.net/10191/42908", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-07-27"}, "publish_date": "2016-07-27", "publish_status": "0", "recid": "18242", "relation": {}, "relation_version_is_last": true, "title": ["心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて"], "weko_shared_id": null}
  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第110巻第2号

心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて

http://hdl.handle.net/10191/42908
http://hdl.handle.net/10191/42908
936d856a-ba1f-4ed4-85d2-56914a80c474
名前 / ファイル ライセンス アクション
110(2)_78-85.pdf 110(2)_78-85.pdf (1.8 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-07-27
タイトル
タイトル 心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて
タイトル
言語 en
タイトル 心臓弁置換患者における活性化血小板の検出とその意義 : フローサイトメトリーを用いて
言語
言語 jpn
キーワード
主題Scheme Other
主題 activated platelets
キーワード
主題Scheme Other
主題 flow cytometry
キーワード
主題Scheme Other
主題 CD62P
キーワード
主題Scheme Other
主題 CD63
キーワード
主題Scheme Other
主題 prosthetic heart valve
キーワード
主題Scheme Other
主題 history of prior cerebral infarction
キーワード
主題Scheme Other
主題 活性化血小板
キーワード
主題Scheme Other
主題 フローサイトメトリー
キーワード
主題Scheme Other
主題 人工弁置換
キーワード
主題Scheme Other
主題 脳梗塞の既往
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Direct Detection of Activated Platelets in the Patients with Prosthetic Heart Valve by Flow Cytometry and its Pathophysiological Significance
著者 堀, 知行

× 堀, 知行

WEKO 114321

堀, 知行

Search repository
著者別名
識別子 114322
識別子Scheme WEKO
姓名 Hori, Tomoyuki
抄録
内容記述タイプ Abstract
内容記述 Thromboembolism is frequently observed in patients with prosthetic heart valve and is believed to be a major cause of post-operative morbidity and mortality. The aim of this study is to elucidate the role of activated platelets in the patients with prosthetic heart valve. Forty patients (23 female and 17 male) were operated on between 1967 and 1994 for prosthetic heart valve replacement in our university. Mean age was 55 years (range 2~68). All patients received anti-coagulant therapy. In 40 patients with prosthetic heart valve and 20 normal subjects, activated platelets were detected by flow-cytometric measurement of the proteins CD62P and CD63, which are expressed on the platelet surface membrane during platelet activation. Among healthy volunteers, a small percentage of platelets were activated (CD62P: 3.14±0.82%, CD63: 3.53±1.29%). In contrast, the patients group showed increased percentage of activated platelets. (CD62P: 4.08±2.25%, p=N.S., CD63: 4.82±2.70%, p<0.05). In order to elucidate the pathophysiological role of the activated platelets in the patients, the 40 patients were divided into two groups according to the percentage of the activated platelets; activated platelets group (CD62P≧4.77% or CD63≧6.26%) and non-activated platelets group (CD62P<4.77% and CD63<6.26%). In the two groups, I analyzed the difference of four clinical factors, 1) history of prior cerebral infarction, 2) adequacy of anti-coagulant therapy (thrombotest<15% or not), 3) heart rhythm (atrial fibrillation or sinus rhythm) and, 4) anti-platelet therapy. In the four clinical factors, the history of prior cerebral infarction was significantly higher in the activated group than the non-activated group. These results suggest that activated platelets actually circulate in the peripheral blood of the patients with prosthetic heart valve and are involved in the pathogenesis of thromboembolism such as cerebral infarction.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 110, 号 2, p. 78-85, 発行日 1996-02
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
戻る
0
views
See details
Views

Versions

Ver.1 2021-03-01 14:56:52.838928
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3