{"_buckets": {"deposit": "870f58d3-95e5-4528-aeec-6b2472ec7ed2"}, "_deposit": {"id": "17717", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "17717"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00017717", "sets": ["456", "1122"]}, "item_7_alternative_title_1": {"attribute_name": "その他のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Analysis of Tumor Suppressor Gene Alterations in Human Glioma Cell Lines"}]}, "item_7_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1997-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "56", "bibliographicPageStart": "47", "bibliographicVolumeNumber": "111", "bibliographic_titles": [{"bibliographic_title": "新潟医学会雑誌"}, {"bibliographic_title": "新潟医学会雑誌", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Ten glioma cell lines were examined for alterations of the p16, p15 and p53 genes, which were tumor suppressor genes with direct or indirect CDK inhibitory functions. All the cell lines showed abnormalities in at least 1 gene, often in 2 or 3 genes coincidentally, suggesting that dysfunction of these genes is closely related to glioma cell growth. On examination of the primary tumor tissues, the same alterations of the p16/p15 and p53 genes as detected in the cell lines were demonstrated in all 6 cases examined, p16/p15 gene deletion in 1, p16 gene mutation in 1 and p53 gene mutations in 5 cases. This suggested that the p16/p15 and p53 gene alterations and their combinations in at least some glioma cell lines reflected those in the primary glioma tissues.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "111503", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Zhang, Shu-Jing"}]}, {"nameIdentifiers": [{"nameIdentifier": "111504", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kumanishi, Toshiro"}]}]}, "item_7_publisher_7": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "新潟医学会"}]}, "item_7_select_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "張, 淑靖"}], "nameIdentifiers": [{"nameIdentifier": "111501", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "熊西, 敏郎"}], "nameIdentifiers": [{"nameIdentifier": "111502", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "111(1)_47-56.pdf", "filesize": [{"value": "1.9 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1900000.0, "url": {"label": "111(1)_47-56.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/17717/files/111(1)_47-56.pdf"}, "version_id": "4d1dc548-51ea-4841-8c36-0d6984d62cbe"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Glioma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Brain tumor", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tumor suppressor gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p16 gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p15 gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p21 gene", "subitem_subject_scheme": "Other"}, {"subitem_subject": "グリオーマ", "subitem_subject_scheme": "Other"}, {"subitem_subject": "脳腫瘍", "subitem_subject_scheme": "Other"}, {"subitem_subject": "がん抑制遺伝子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p16 遺伝子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p15 遺伝子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p53 遺伝子", "subitem_subject_scheme": "Other"}, {"subitem_subject": "p21 遺伝子", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "グリオーマ細胞株におけるがん抑制遺伝子変化の解析", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "グリオーマ細胞株におけるがん抑制遺伝子変化の解析"}, {"subitem_title": "グリオーマ細胞株におけるがん抑制遺伝子変化の解析", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["456", "1122"], "permalink_uri": "http://hdl.handle.net/10191/44417", "pubdate": {"attribute_name": "公開日", "attribute_value": "2016-10-21"}, "publish_date": "2016-10-21", "publish_status": "0", "recid": "17717", "relation": {}, "relation_version_is_last": true, "title": ["グリオーマ細胞株におけるがん抑制遺伝子変化の解析"], "weko_shared_id": null}