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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第111巻第7号

3)-1 消炎鎮痛薬(シンポジウム 薬剤の副作用, 第518回新潟医学会)

http://hdl.handle.net/10191/45153
http://hdl.handle.net/10191/45153
2423aa7f-614a-4d54-b937-c53b8a3ae565
名前 / ファイル ライセンス アクション
111(7)_429-432.pdf 111(7)_429-432.pdf (734.4 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2016-12-21
タイトル
タイトル 3)-1 消炎鎮痛薬(シンポジウム 薬剤の副作用, 第518回新潟医学会)
タイトル
言語 en
タイトル 3)-1 消炎鎮痛薬(シンポジウム 薬剤の副作用, 第518回新潟医学会)
言語
言語 jpn
キーワード
主題Scheme Other
主題 nonsteroidal anti-inflammatory drugs (NSAIDs)
キーワード
主題Scheme Other
主題 renal disorder
キーワード
主題Scheme Other
主題 gastrointestinal disorder
キーワード
主題Scheme Other
主題 非ステロイド系抗炎症薬
キーワード
主題Scheme Other
主題 腎障害
キーワード
主題Scheme Other
主題 胃腸障害
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Side Effects of Nonsteroidal Anti-Inflammatory Drugs (Adverse Effects of Drugs : The Mechanism and Clinical Prevention)
著者 中野, 正明

× 中野, 正明

WEKO 109170

中野, 正明

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著者別名
識別子 109171
識別子Scheme WEKO
姓名 Nakano, Masaaki
抄録
内容記述タイプ Abstract
内容記述 Nonsteroidal anti-inflammatory drugs (NSAIDs) are now the most commonly prescribed agents in the treatment of rheumatic diseases because of their analgesic and anti-inflammatory properties. The major mechanism whereby NSAIDs achieve their anti-inflammatory effects has been shown to be the inhibition of prostaglandin (PG) biosynthesis. An increasing number of patients have developed serious complications from NSAIDs. This inhibition is documented to be a cause of adverse reactions of NSAIDs. Among these complications, we reviewed and discussed gastrointestinal (GI) and renal disorders in this symposium. Of 1008 Japanese RA patients taking NSAIDs, gastric ulcer was noticed in 15.5% of the cases. The high prevalence of GI injury in RA patients has been esteemed to be responsible for the use of NSAIDs. The following 4 types of drugs are known to be useful for prevention of NSAIDs-related GI mucosal damage:histamine-receptor antagonist;gastric acid pump inhibitor;barrier agents;and PG analogue. A PG analogue, misoprostol, was to be the most effective agent. Furthermore, NO-releasing NSAIDs, which were recently developed, may be able to reduce adverse reactions of GI tract. NSAIDs may cause renal disorders by different mechanisms, including reversible renal hypoperfusion, acute tubular necrosis, or acute tubulointerstitial nephritis with or without nephrotic syndrome. The long-term treatment with NSAIDs may produce a subclinical renal dysfunction. Furthermore, severe renal dysfunction are likely to develop in patients with poor perfusion. Irreversible renal failure may also develop in patients receiving other medications that may have contributed to renal dysfunction. Selective cyclooxygenase-2 inhibitors such as etodolac have shown the lower incidence of adverse reactions in GI tract and kidney than other conventional NSAIDs. Misoprostol can also minimize NSAIDs-induced renal dysfunction without affecting pain control.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 111, 号 7, p. 429-432, 発行日 1997-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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