WEKO3
-
RootNode
アイテム
中枢神経系の病巣修復：シナプス再生
http://hdl.handle.net/10191/45796
http://hdl.handle.net/10191/457966b15b6dd-ff02-45e6-b8eb-fc97bd4b16cd
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
112(4)_159-162.pdf (656.1 kB)
|
|
| Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2017-01-26 | |||||
| タイトル | ||||||
| タイトル | 中枢神経系の病巣修復：シナプス再生 | |||||
| タイトル | ||||||
| タイトル | 中枢神経系の病巣修復：シナプス再生 | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | lesion repair | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | synaptic regeneration | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | central nervous system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 病巣修復 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | シナプス再生 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 中枢神経系 | |||||
| 資源タイプ | ||||||
| 資源 | http://purl.org/coar/resource_type/c_6501 | |||||
| タイプ | departmental bulletin paper | |||||
| その他のタイトル | ||||||
| その他のタイトル | Lesion Repair of the Central Nervous System：Synaptic Regeneration | |||||
| 著者 |
山田, 光則
× 山田, 光則 |
|||||
| 著者別名 | ||||||
| 識別子Scheme | WEKO | |||||
| 識別子 | 106501 | |||||
| 姓名 | Yamada, Mitsunori | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | To elucidate the regenerative profile of synapses, we investigated immunohistochemically the repair process of cold lesion formed in the adult rat cerebrum. The expression of presynaptic molecules, such as synaptophysin and growth-associated protein 43 (GAP-43), was up-regulated around the lesions in a coarse-granular pattern, begining 5 days after injury and lasting for about 10 days. The appearance of many growth cones was clearly demonstrated in this border zone by GAP-43-immunohistochemistry on 5 and 7 days after the lesioning procedure. In this region, postsynaptic molecules such as IP3 kinase, postsynaptic density 95 and drebrin temporarily lost their punctate immunostaining from 3 days after injury, but reappeared in a finely granular pattern at around 2 weeks after the lesioning. Synaptic number in this border zone decreased to 43.3 % of normal control on 5 days after injury, but was rapidly recovered to 66.7 % on 14 days and reached to 85.6 % on 21 days. This dynamic change of synaptic number was largely dependent on disappearance and following regeneration of spine synapses. | |||||
| 書誌情報 |
新潟医学会雑誌 en : 新潟医学会雑誌 巻 112, 号 4, p. 159-162, 発行日 1998-04 |
|||||
| 出版者 | ||||||
| 出版者 | 新潟医学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 00290440 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AN00182415 | |||||
| 著者版フラグ | ||||||
| 値 | publisher | |||||
