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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第4号

中枢神経系の病巣修復:シナプス再生

http://hdl.handle.net/10191/45796
http://hdl.handle.net/10191/45796
6b15b6dd-ff02-45e6-b8eb-fc97bd4b16cd
名前 / ファイル ライセンス アクション
112(4)_159-162.pdf 112(4)_159-162.pdf (656.1 kB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-01-26
タイトル
タイトル 中枢神経系の病巣修復:シナプス再生
タイトル
言語 en
タイトル 中枢神経系の病巣修復:シナプス再生
言語
言語 jpn
キーワード
主題Scheme Other
主題 lesion repair
キーワード
主題Scheme Other
主題 synaptic regeneration
キーワード
主題Scheme Other
主題 central nervous system
キーワード
主題Scheme Other
主題 病巣修復
キーワード
主題Scheme Other
主題 シナプス再生
キーワード
主題Scheme Other
主題 中枢神経系
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Lesion Repair of the Central Nervous System:Synaptic Regeneration
著者 山田, 光則

× 山田, 光則

WEKO 106500

山田, 光則

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著者別名
識別子 106501
識別子Scheme WEKO
姓名 Yamada, Mitsunori
抄録
内容記述タイプ Abstract
内容記述 To elucidate the regenerative profile of synapses, we investigated immunohistochemically the repair process of cold lesion formed in the adult rat cerebrum. The expression of presynaptic molecules, such as synaptophysin and growth-associated protein 43 (GAP-43), was up-regulated around the lesions in a coarse-granular pattern, begining 5 days after injury and lasting for about 10 days. The appearance of many growth cones was clearly demonstrated in this border zone by GAP-43-immunohistochemistry on 5 and 7 days after the lesioning procedure. In this region, postsynaptic molecules such as IP3 kinase, postsynaptic density 95 and drebrin temporarily lost their punctate immunostaining from 3 days after injury, but reappeared in a finely granular pattern at around 2 weeks after the lesioning. Synaptic number in this border zone decreased to 43.3 % of normal control on 5 days after injury, but was rapidly recovered to 66.7 % on 14 days and reached to 85.6 % on 21 days. This dynamic change of synaptic number was largely dependent on disappearance and following regeneration of spine synapses.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 4, p. 159-162, 発行日 1998-04
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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