{"_buckets": {"deposit": "6f5c18ee-ab85-4b42-9fcc-cca1fe0c0d54"}, "_deposit": {"id": "16675", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "16675"}, "status": "published"}, "_oai": {"id": "oai:niigata-u.repo.nii.ac.jp:00016675"}, "item_7_alternative_title_1": {"attribute_name": "\u305d\u306e\u4ed6\u306e\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_alternative_title": "The Effects of Ketamine and Thiopental on Vasorelaxation Induced by Polymorphonuclear Leukocytes"}]}, "item_7_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "1998-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageEnd": "350", "bibliographicPageStart": "344", "bibliographicVolumeNumber": "112", "bibliographic_titles": [{"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c"}, {"bibliographic_title": "\u65b0\u6f5f\u533b\u5b66\u4f1a\u96d1\u8a8c", "bibliographic_titleLang": "en"}]}]}, "item_7_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "The effects of the commonly-used intravenous anesthetics, ketamine and thiopental (10^\u003c-5\u003e, 3x10.^\u003c-5\u003e, and 10^\u003c-4\u003eM), on vasorelaxation induced by polymorphonuclear leukocytes(PMNLs) were investigated using the porcine coronary artery. Ketamine, 10^\u003c-4\u003eM, enhanced the PMNLs-induced vasorelaxation, whereas thiopental had no effect. Katamine in concentrations over 10^\u003c-4\u003e M increased the appearance of a cell adhesion molecule, L-selectin(CD62L) on PMNLs measured by flow cytometer. Concanavalin A(Con-A) and lens culinarins agglutinin (LCA), which are kinds of lectin, caused endothelium-dependent vasorelaxation. The PMNLs-induced vasorelaxation was abolished in KCI(25mM)-contracted and ouabain(10^\u003c-5\u003e M)-treated preparation s, and was attenuated by 10^\u003c-2\u003e M tetreathylammonium(TEA), 10^\u003c-2\u003e M tetrabutylammonium (TBA), and 10^\u003c-7\u003e M charybdotoxin(ChTx), but not by 10^\u003c-3\u003e M 4-aminopyridine and  10^\u003c-6\u003e M glibenclamide. The relaxation by Con-A and LCA was also attenuated by TEA and TBA. The findings suggest that PMNLs-induced vasorelaxation is at least in part produced through the calcium dependent potassium channel. However, the facilitation of Na^+ pump cannot be excluded in the mechanism of vasodilation by PMNLs. Oxygen free radical scavengers, superoxide dismutase (150 U/ml), catalase (1200 U/ml), and manittol (80mM) had no influence on the PMNLs-induced  vasorelaxation. These findings suggest that lectins induce vasorelaxation partly through calcium dependent potassium channel, and also that ketamine-induced enhancement of the relaxation by PMNLs is produced by increased appearance of L-selectin.", "subitem_description_type": "Abstract"}]}, "item_7_full_name_3": {"attribute_name": "\u8457\u8005\u5225\u540d", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "105929", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Kinoshita, Hidenori"}]}]}, "item_7_publisher_7": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "\u65b0\u6f5f\u533b\u5b66\u4f1a"}]}, "item_7_select_19": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_7_source_id_11": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00182415", "subitem_source_identifier_type": "NCID"}]}, "item_7_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "00290440", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u6728\u4e0b, \u79c0\u5247"}], "nameIdentifiers": [{"nameIdentifier": "105928", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "112(6)_344-350.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "112(6)_344-350.pdf", "url": "https://niigata-u.repo.nii.ac.jp/record/16675/files/112(6)_344-350.pdf"}, "version_id": "668084b9-7940-42ae-b83f-690d44494c69"}]}, "item_keyword": {"attribute_name": "\u30ad\u30fc\u30ef\u30fc\u30c9", "attribute_value_mlt": [{"subitem_subject": "polymorphonuclear leukocyte(PMNL)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endothelium", "subitem_subject_scheme": "Other"}, {"subitem_subject": "endothelium-derived hyperpolarizing factor(EDHF)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "L-selectin", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u591a\u6838\u767d\u8840\u7403", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u8840\u7ba1\u5185\u76ae", "subitem_subject_scheme": "Other"}, {"subitem_subject": "\u5185\u76ae\u7531\u6765\u904e\u5206\u6975\u56e0\u5b50", "subitem_subject_scheme": "Other"}, {"subitem_subject": "L-\u30bb\u30ec\u30af\u30c1\u30f3", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "\u8a00\u8a9e", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "\u8cc7\u6e90\u30bf\u30a4\u30d7", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "\u767d\u8840\u7403\u306b\u3088\u308b\u8840\u7ba1\u5f1b\u7de9\u306b\u53ca\u307c\u3059\u9759\u8108\u9ebb\u9154\u85ac\u30b1\u30bf\u30df\u30f3\u53ca\u3073\u30b5\u30a4\u30aa\u30da\u30f3\u30bf\u30fc\u30eb\u306e\u5f71\u97ff", "item_titles": {"attribute_name": "\u30bf\u30a4\u30c8\u30eb", "attribute_value_mlt": [{"subitem_title": "\u767d\u8840\u7403\u306b\u3088\u308b\u8840\u7ba1\u5f1b\u7de9\u306b\u53ca\u307c\u3059\u9759\u8108\u9ebb\u9154\u85ac\u30b1\u30bf\u30df\u30f3\u53ca\u3073\u30b5\u30a4\u30aa\u30da\u30f3\u30bf\u30fc\u30eb\u306e\u5f71\u97ff"}, {"subitem_title": "\u767d\u8840\u7403\u306b\u3088\u308b\u8840\u7ba1\u5f1b\u7de9\u306b\u53ca\u307c\u3059\u9759\u8108\u9ebb\u9154\u85ac\u30b1\u30bf\u30df\u30f3\u53ca\u3073\u30b5\u30a4\u30aa\u30da\u30f3\u30bf\u30fc\u30eb\u306e\u5f71\u97ff", "subitem_title_language": "en"}]}, "item_type_id": "7", "owner": "1", "path": ["453/456", "471/537/538/1107"], "permalink_uri": "http://hdl.handle.net/10191/45918", "pubdate": {"attribute_name": "\u516c\u958b\u65e5", "attribute_value": "2017-02-01"}, "publish_date": "2017-02-01", "publish_status": "0", "recid": "16675", "relation": {}, "relation_version_is_last": true, "title": ["\u767d\u8840\u7403\u306b\u3088\u308b\u8840\u7ba1\u5f1b\u7de9\u306b\u53ca\u307c\u3059\u9759\u8108\u9ebb\u9154\u85ac\u30b1\u30bf\u30df\u30f3\u53ca\u3073\u30b5\u30a4\u30aa\u30da\u30f3\u30bf\u30fc\u30eb\u306e\u5f71\u97ff"], "weko_shared_id": null}