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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第6号

白血球による血管弛緩に及ぼす静脈麻酔薬ケタミン及びサイオペンタールの影響

http://hdl.handle.net/10191/45918
http://hdl.handle.net/10191/45918
58cd9813-2cb3-443b-9966-401b9470001c
名前 / ファイル ライセンス アクション
112(6)_344-350.pdf 112(6)_344-350.pdf (1.1 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-01
タイトル
タイトル 白血球による血管弛緩に及ぼす静脈麻酔薬ケタミン及びサイオペンタールの影響
タイトル
言語 en
タイトル 白血球による血管弛緩に及ぼす静脈麻酔薬ケタミン及びサイオペンタールの影響
言語
言語 jpn
キーワード
主題Scheme Other
主題 polymorphonuclear leukocyte(PMNL)
キーワード
主題Scheme Other
主題 endothelium
キーワード
主題Scheme Other
主題 endothelium-derived hyperpolarizing factor(EDHF)
キーワード
主題Scheme Other
主題 L-selectin
キーワード
主題Scheme Other
主題 多核白血球
キーワード
主題Scheme Other
主題 血管内皮
キーワード
主題Scheme Other
主題 内皮由来過分極因子
キーワード
主題Scheme Other
主題 L-セレクチン
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル The Effects of Ketamine and Thiopental on Vasorelaxation Induced by Polymorphonuclear Leukocytes
著者 木下, 秀則

× 木下, 秀則

WEKO 105928

木下, 秀則

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著者別名
識別子 105929
識別子Scheme WEKO
姓名 Kinoshita, Hidenori
抄録
内容記述タイプ Abstract
内容記述 The effects of the commonly-used intravenous anesthetics, ketamine and thiopental (10^<-5>, 3x10.^<-5>, and 10^<-4>M), on vasorelaxation induced by polymorphonuclear leukocytes(PMNLs) were investigated using the porcine coronary artery. Ketamine, 10^<-4>M, enhanced the PMNLs-induced vasorelaxation, whereas thiopental had no effect. Katamine in concentrations over 10^<-4> M increased the appearance of a cell adhesion molecule, L-selectin(CD62L) on PMNLs measured by flow cytometer. Concanavalin A(Con-A) and lens culinarins agglutinin (LCA), which are kinds of lectin, caused endothelium-dependent vasorelaxation. The PMNLs-induced vasorelaxation was abolished in KCI(25mM)-contracted and ouabain(10^<-5> M)-treated preparation s, and was attenuated by 10^<-2> M tetreathylammonium(TEA), 10^<-2> M tetrabutylammonium (TBA), and 10^<-7> M charybdotoxin(ChTx), but not by 10^<-3> M 4-aminopyridine and 10^<-6> M glibenclamide. The relaxation by Con-A and LCA was also attenuated by TEA and TBA. The findings suggest that PMNLs-induced vasorelaxation is at least in part produced through the calcium dependent potassium channel. However, the facilitation of Na^+ pump cannot be excluded in the mechanism of vasodilation by PMNLs. Oxygen free radical scavengers, superoxide dismutase (150 U/ml), catalase (1200 U/ml), and manittol (80mM) had no influence on the PMNLs-induced vasorelaxation. These findings suggest that lectins induce vasorelaxation partly through calcium dependent potassium channel, and also that ketamine-induced enhancement of the relaxation by PMNLs is produced by increased appearance of L-selectin.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 6, p. 344-350, 発行日 1998-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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