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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第6号

血管平滑筋に存在するミオシン軽鎖脱リン酸化酵素のミオシン結合サブユニットについて: cGMP依存性タンパク質リン酸化酵素蔓によるリン酸化とG_1リン酸化タンパク質との類似性

http://hdl.handle.net/10191/45917
http://hdl.handle.net/10191/45917
9d013a1c-85a5-4b6e-b399-9203737ea56f
名前 / ファイル ライセンス アクション
112(6)_334-343.pdf 112(6)_334-343.pdf (2.0 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-01
タイトル
タイトル 血管平滑筋に存在するミオシン軽鎖脱リン酸化酵素のミオシン結合サブユニットについて: cGMP依存性タンパク質リン酸化酵素蔓によるリン酸化とG_1リン酸化タンパク質との類似性
タイトル
言語 en
タイトル 血管平滑筋に存在するミオシン軽鎖脱リン酸化酵素のミオシン結合サブユニットについて: cGMP依存性タンパク質リン酸化酵素蔓によるリン酸化とG_1リン酸化タンパク質との類似性
言語
言語 jpn
キーワード
主題Scheme Other
主題 myosin light chain phosphatase
キーワード
主題Scheme Other
主題 cGMP-dependent protain kinase
キーワード
主題Scheme Other
主題 thiophosphorylation
キーワード
主題Scheme Other
主題 Ca^<2+>sensitivity
キーワード
主題Scheme Other
主題 ミオシン軽鎖脱リン酸化酵素
キーワード
主題Scheme Other
主題 cGMP-依存性タンパク質リン酸化酵素
キーワード
主題Scheme Other
主題 チオリン酸化
キーワード
主題Scheme Other
主題 Ca^<2+>感受性
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Myosin Binding Subunit of Myosin Light Chain Phosphatase of Vascular Smooth Muscle : Phosphorylation by cGMP-Dependent Protein Kinase and Close Resemblance to G_1 Phosphoprotein
著者 藤田, 聡

× 藤田, 聡

WEKO 105926

藤田, 聡

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著者別名
識別子 105927
識別子Scheme WEKO
姓名 Fujita, Satoru
抄録
内容記述タイプ Abstract
内容記述 A 138kDa protein, immunoreactive with an antibody to myosin binding subunit (MBS) of chicken gizzard myosin light chain phosphatase( MLCP), was detected in microsomes as well as myofubrillar fraction from porcine aorta. The 138kDa protein that was purified by immunoprecipitation with the antibody either from microsomes or myofibrillar fraction was found to be a good substrate for cGMP-dependent protein kinase(PKG). The microsomal protein was tightly associated with membranes and could be solubilized by Triton X-100, a property reminiscent of G_1 phosphoprotein, the unidentified major PKG substrate in the vascular smooth muscle. Both proteins co-migrated on SDS-PAGE and the MBS antibody immunoprecipitated thiophosphorylated G_1. Thus, MBS is a substrate for PKG, and the membrane-bound MBS may be identical to G_1, or at least its constituent. We propose that phosphorylation of MBS by PKG may be responsible for cGMP-induced Ca^<2+>-desensitization of contractile machinery in vascular smooth mustle.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 6, p. 334-343, 発行日 1998-06
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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