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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第7号

トリプレットリピート病の神経生理学的特徴に関する研究 : 病態生理とCAGリピートとの相関

http://hdl.handle.net/10191/45977
http://hdl.handle.net/10191/45977
0060c3c0-88c9-4321-84ab-621248ba5d60
名前 / ファイル ライセンス アクション
112(7)_414-428.pdf 112(7)_414-428.pdf (2.2 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-02
タイトル
タイトル トリプレットリピート病の神経生理学的特徴に関する研究 : 病態生理とCAGリピートとの相関
タイトル
言語 en
タイトル トリプレットリピート病の神経生理学的特徴に関する研究 : 病態生理とCAGリピートとの相関
言語
言語 jpn
キーワード
主題Scheme Other
主題 triplet repeat disease
キーワード
主題Scheme Other
主題 CAG repeat
キーワード
主題Scheme Other
主題 Bulbospinal muscular atrophy
キーワード
主題Scheme Other
主題 Machado-Joseph disease
キーワード
主題Scheme Other
主題 SCA 6
キーワード
主題Scheme Other
主題 evoked potentials
キーワード
主題Scheme Other
主題 トリプレットリピート病
キーワード
主題Scheme Other
主題 CAGリピート
キーワード
主題Scheme Other
主題 球脊髄性筋萎縮症
キーワード
主題Scheme Other
主題 脊髄小脳失調症6型
キーワード
主題Scheme Other
主題 マシャドージョセブ病
キーワード
主題Scheme Other
主題 誘発電位
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Neurophysiological Findings in Triplet Repeat Disease : Pathophysiology and Correlation to the CAG Repeat
著者 本間, 篤

× 本間, 篤

WEKO 105639

本間, 篤

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著者別名
識別子 105640
識別子Scheme WEKO
姓名 Homma, Atsushi
抄録
内容記述タイプ Abstract
内容記述 To clarify the neurophysiological abnormality of triplet repeat diseases, and to elucidate how the expanded CAG repeats affect physiological properties of the nervous system, I investigated the correlation between CAG repeat and various parameters of evoked potentials. Nerve conduction studies (NCS), somatosensory evoked potentials (SEP) and auditory brainstem responses (ABR) were performed in patients with bulbospinal muscular atrophy (SBMA), Machado-Joseph disease (MJD) and SCA 6. In SBMA patients, main characteristic findings were reduction of the amplitudes in NCS and SEP. Only the N24 amplitudes in tibial nerve SEP inversely correlated the CAG repeat number. The central conduction time (CCT) of tibial nerve SEP in MJD patients was significantly prolonged and correlated with the expanded CAG repeat size. The wave III latency of ABR in MJD patients and the wave I and V latencies of ABR in SCA 6 patients were significantly prolonged without correlation to the expanded CAG repeat sizes. The amplitude of N24 in SBMA patients and tibial nerve CCT in MJD patients correlated the expanded CAG repeat size, which may provide an evidence that expanded CAG repeats affect the sensory system. Electrophysiological analyses are useful elucidation how the expanded CAG repeat affect the function of nervous system in patients with triplet repeat diseases.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 7, p. 414-428, 発行日 1998-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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