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  1. 0 資料タイプ別
  2. 03 紀要論文
  1. 250 大学院医歯学総合研究科(医)
  2. 20 紀要
  3. 02 新潟医学会雑誌
  4. 第112巻第7号

マウス歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)遺伝子のcDNAのクローニング

http://hdl.handle.net/10191/45976
http://hdl.handle.net/10191/45976
7c255df2-bfb6-4ec1-bd0d-925f4eb1e2b6
名前 / ファイル ライセンス アクション
112(7)_400-413.pdf 112(7)_400-413.pdf (2.3 MB)
Item type 紀要論文 / Departmental Bulletin Paper(1)
公開日 2017-02-02
タイトル
タイトル マウス歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)遺伝子のcDNAのクローニング
タイトル
言語 en
タイトル マウス歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)遺伝子のcDNAのクローニング
言語
言語 jpn
キーワード
主題Scheme Other
主題 Dentatorubral-pallidoluysian atrophy(DRPLA)
キーワード
主題Scheme Other
主題 cDNA cloning,
キーワード
主題Scheme Other
主題 murine homologue
キーワード
主題Scheme Other
主題 CAG repeat
キーワード
主題Scheme Other
主題 歯状核赤核淡蒼球ルイ体萎縮症(DRPLA)
キーワード
主題Scheme Other
主題 cDNAクローニング
キーワード
主題Scheme Other
主題 マウス相同遺伝子
キーワード
主題Scheme Other
主題 CAGリピート
資源タイプ
資源 http://purl.org/coar/resource_type/c_6501
タイプ departmental bulletin paper
その他のタイトル
その他のタイトル Molecular Cloning of Murine Homologue Dentatorubral-pallidoluysian Atrophy (DRPLA) cDNA
著者 小宅, 睦郎

× 小宅, 睦郎

WEKO 105637

小宅, 睦郎

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著者別名
識別子 105638
識別子Scheme WEKO
姓名 Oyake, Mutsuo
抄録
内容記述タイプ Abstract
内容記述 Dentatorubral-pallidoluysian atrophy(DRPLA)is an autosomal dominant neurodegenerative disease caused by expansion of an unstable CAG repeat in a novel gene mapped to chromosome 12p. Although nucleotide sequence of this gene transcript and its expession in both normal and affected individuals are determined, the functions of this gene product and the mechanisms responsible for selective neuronal death remain to be elucidated. As a first step to develop an animal model for DRPLA, we isolated a murine homolouge cDNA for DRPLA. The consensus cDNA spanned 4103 bp. encoding 1175 amino acids protein. The murine homolouge exhibited 86 % nucleotide and 92 % amino acid identities to the corresponding human sequences. Nucleotide sequece analysis revealed that murine cDNA contained shorter CAG repeat than that of human DRPLA cDNA. The CAG repeat ranged from three to eight repeat. The numbers of CAG repeats varied among different phylogenetic mice but were constant within the same phylogenetic ones. Northern blot analysis revealed that a single 4.5 kb. transcript was widely expressed in all tissues examined and most abundant in brain. During embryonal stages, DRPLA mRNA was expressed with little variation.
書誌情報 新潟医学会雑誌
en : 新潟医学会雑誌

巻 112, 号 7, p. 400-413, 発行日 1998-07
出版者
出版者 新潟医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 00290440
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AN00182415
著者版フラグ
値 publisher
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